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1:29:30EN
Cognitive Revolution "How AI Changes Everything"· Oct 14, 2025Podcast2,500 Compounds and a 51 Percent Hit Rate: How a Small Graph Net Found New AntibioticsHost Nathan LabenzMIT's Jim Collins tells Nathan Labenz how a bootlegged 2018 project, a binary growth-inhibition label, and Chemprop graph networks pulled novel antibiotics out of chemical space that labs could never screen by hand.
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No Priors: AI, Machine Learning, Tech, & Startups· Oct 9, 2025Podcast · 2 speakersSTaR's Author Wants Models With EQ, Not Just More IQHost Sarah Guo, Elad GilEric Zelikman, the Stanford and xAI researcher behind STaR and Quiet-STaR, launches humans& on the bet that three years of IQ scaling left models emotionally unintelligent.
1:01:49ENCognitive Revolution "How AI Changes Everything"· Oct 2, 2025PodcastChatGPT's Co-Creator Left to Put Nature in the Reward LoopHost Nathan LabenzLiam Fedus and Ekin Dogus Cubuk on why language models still fail at physics, why literature data is too noisy to train on, and why Periodic Labs is aiming at a 200K superconductor.
1:22:07ENCognitive Revolution "How AI Changes Everything"· Sep 25, 2025PodcastEvery payment is a frame in a movie. Stripe’s foundation model took card-testing detection from 59% to 97%Host Nathan LabenzEmily Sands, Stripe’s head of data and AI, explains how a domain-specific payments model, shared embeddings, and mixed rules turn a $1.4 trillion network into compounding advantage.
2:02:17ENCognitive Revolution "How AI Changes Everything"· Aug 27, 2025PodcastSAEs Find the Nouns. Parameter Decomposition Looks for the VerbsHost Nathan LabenzGoodfire's Lee Sharkey argues that sparse autoencoders recover a network's variables, not the algorithms those variables run, and shows how stochastic parameter decomposition tries to recover the computations themselves.
57:52EN
Unsupervised Learning: With Jacob Effron· Aug 13, 2025PodcastThey Aimed for 1%. The Lab Hit 20%. Chai Discovery Moved Antibody Design Onto the Computer.Host Jacob EffronJoshua Meier on three waves of AI drug discovery, why Chai-2 behaves like Photoshop for molecules, and why a 1% hit rate was supposed to be enough to change the industry.
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Sequoia Capital· Jul 30, 2025PodcastFrom 12 Percent on AIME to IMO Gold in Two MonthsAlex Wei, Sheryl Hsu, and Noam Brown tell Sequoia's Sonya Huang how a three-person OpenAI sprint used general-purpose reinforcement learning, not Lean, to reach gold-level on the 2025 International Mathematical Olympiad.
38:10ENCognitive Revolution "How AI Changes Everything"· Jul 16, 2025PodcastPlus Five for Format, Plus Ten if It CompilesHost Nathan LabenzPredibase CEO Dev Rishi explains how reinforcement fine-tuning, production feedback, and narrow specialist models turn one-off training into systems that keep learning.
1:42:06ENCognitive Revolution "How AI Changes Everything"· Jul 8, 2025PodcastEvery Frontier Lab Is Spending a Billion a Year on Data. Here Is Where It GoesHost Nathan LabenzLabelbox CEO Manu Sharma on the $15 billion Scale deal, RL “gyms,” $250,000 trainers, and why post-training now eats the budget that used to belong to pre-training.
1:37:05ENCognitive Revolution "How AI Changes Everything"· Jun 19, 2025PodcastAn Algebraic Geometer Quit Tenure Because the Bowl-Shaped Loss Plot Is a LieHost Nathan LabenzJesse Hoogland and Daniel Murfet of Timaeus argue that singularities in the loss landscape — not the smooth valleys in every slide deck — are what actually govern how neural networks learn, generalize, and go wrong.
48:51ENSequoia Capital· Jun 17, 2025PodcastThe Breakthroughs for AGI Are Already Done, Says OpenAI’s Former Research HeadBob McGrew tells Sequoia’s Training Data that 2025 is the year of reasoning, agents will be priced at the cost of compute, and nothing fundamental will be added to the stack by 2035.
1:54:08ENCognitive Revolution "How AI Changes Everything"· May 29, 2025PodcastWhy Anthropic's first check went to a company building microscopes for neural netsHost Nathan LabenzGoodfire's Dan Balsam and Tom McGrath argue that mechanistic interpretability now has a proto-paradigm, two stubborn gaps, and three products worth shipping today.
2:12:00ENCognitive Revolution "How AI Changes Everything"· May 15, 2025PodcastGradient Descent at Test Time: Titans Pushes LLM Context to 10 Million TokensHost Nathan LabenzA Cornell PhD student's neural memory module holds about 70% accuracy where GPT-4's scores fall off a cliff.
47:00ENUnsupervised Learning: With Jacob Effron· May 8, 2025PodcastAn Eval Lasts Three Months — and a Frozen Frontier Would Still Feed Startups for a DecadeHost Jacob EffronOpenAI’s GPT-4.1 post-training lead Michelle Pokrass tells Unsupervised Learning how the team spent three months on evals before training, why agents fail on wiring more than intelligence, and when to reach for RFT.
38:10ENNo Priors: AI, Machine Learning, Tech, & Startups· May 1, 2025Podcast · 2 speakerso3 should wait exactly as long as the answer takesHost Sarah Guo, Elad GilOpenAI researchers Eric Mitchell and Brandon McKinzie tell No Priors why o3's leap is a chain of tools during reasoning — and why you should send the same prompt a hundred times.
58:11ENSequoia Capital· Apr 15, 2025PodcastPatrick Hsu Wants an App Store for Biology, Not Just Better DrugsThe Arc Institute co-founder argues that Evo 2, trained on genomes rather than proteins, should underpin tools for every step of the scientific method.
1:14:11ENCognitive Revolution "How AI Changes Everything"· Apr 5, 2025PodcastThe Reasoning Curve Was Smooth All Along: Gemini 2.5's Jack Rae on Thinking, Memory, and AGIHost Nathan LabenzDeepMind's thinking-and-inference lead explains why RL-for-reasoning felt sudden, why Gemini shows raw chain of thought, and why a million-token window still is not memory.
1:43:54ENCognitive Revolution "How AI Changes Everything"· Mar 23, 2025PodcastA Year to Grow a Brain Organoid, an Hour to Simulate ItHost Nathan LabenzStanford postdoc Siyu He tells Nathan Labenz how Squidiff and CORAL move single-cell and spatial experiments into the computer — and where the models still cannot go.
35:14ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 20, 2025Podcast · 2 speakersRobots Have No Wikipedia. Chelsea Finn Is Starting With Three Buildings.Host Sarah Guo, Elad GilPhysical Intelligence’s cofounder tells No Priors why a generalist robot model has to be trained across embodiments, why open-sourcing hardware is a bet against the problem going unsolved, and why humanoids are a little overrated.
1:10:23ENUnsupervised Learning: With Jacob Effron· Mar 17, 2025PodcastA Million Tokens per Dollar: Why Noam Shazeer Thinks Inference Compute Is Still UntappedHost Jacob EffronThe Transformer co-inventor and Gemini researcher Jack Rae walk through test-time compute, Ilya Sutskever's AGI critique, and a four-year-old who now lectures his teacher about lizards.
1:56:38ENCognitive Revolution "How AI Changes Everything"· Mar 8, 2025Podcasto3 took ARC from 20% to 87%. Nathan Labenz sketches early superintelligenceHost Nathan LabenzOn Consistently Candid, the Cognitive Revolution host argues that math and coding will be superhuman by 2026, and that a reasoning core plus specialist “intuitive physics” may already be enough.
57:41ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 25, 2025Podcast · 2 speakersA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentHost Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
22:32ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 7, 2025Podcast · 2 speakersThe $5.5 Million Was Only the Last MileHost Sarah Guo, Elad GilOn No Priors' 100th episode, Sarah Guo and Elad Gil separate DeepSeek's paper cost from the compute behind it, then walk through OpenAI's Deep Research, Stargate, and their bets for 2025.
1:48:20ENCognitive Revolution "How AI Changes Everything"· Jan 25, 2025PodcastFrom 15% to 70% on Right-or-Wrong Scores: DeepSeek-R1 Laid Reinforcement Learning's Cards on the TableHost Nathan LabenzOn Inauguration Day 2025, DeepSeek and Moonshot dropped reasoning-model results that Nathan Labenz reads as proof the reinforcement-learning recipe is simple, public, and still climbing.Load moreShowing 24 of 196