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No Priors: AI, Machine Learning, Tech, & Startups· Aug 21, 2025Podcast · 2 speakersHire the AI First: Andrew Ng on Agentic Workflows and the Scarcity of JudgmentHost Sarah Guo, Elad GilOn No Priors, Andrew Ng argues that agentic AI has made software cheap and fast, which moves the bottleneck to product judgment, error analysis, and the instinct to try an AI before adding headcount.
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Cognitive Revolution "How AI Changes Everything"· Aug 16, 2025Podcast$500, 2,000 Steps, and a Vending Machine: Grok 4 Profited, Claude Called the FBIHost Nathan LabenzAndon Labs put frontier models in charge of simulated and real vending machines to see what breaks when nobody is in the loop.
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Sequoia Capital· Jul 22, 2025PodcastA dozen people, 28 minutes, and one shared desktopThe OpenAI trio behind ChatGPT Agent explain how Deep Research and Operator became a virtual computer that can reason for half an hour and still ask you before it spends money.
1:02:54ENNo Priors: AI, Machine Learning, Tech, & Startups· Jul 17, 2025Podcast · 2 speakersEnterprise Coding Tools Flipped the 80/20. Reflection AI Built the Other HalfHost Sarah Guo, Elad GilFormer Gemini reward-model lead Misha Laskin on Asimov, why comprehension beats generation, and why there is no such thing as generalization—only pulling the test distribution into train.
41:13ENSequoia Capital· Jul 11, 2025PodcastFrom 49 Multiplications to 48: DeepMind’s AI Rewrites a Fifty-Year Math RecordPushmeet Kohli explains how AlphaEvolve couples Gemini with evaluators to invent algorithms, prove old conjectures, and change which scientific problems are even worth attempting.
59:38ENSequoia Capital· Jul 1, 2025PodcastElevenLabs Was Supposed to Be RoadkillCo-founder Mati Staniszewski on dirty audio data, prosumer virality, and why voice should become the default interface for technology.
42:09ENNo Priors: AI, Machine Learning, Tech, & Startups· Jun 26, 2025Podcast · 2 speakersAlphaEvolve found algorithms humans missed for 50 years — then sped up Gemini 23%Host Sarah Guo, Elad GilGoogle DeepMind’s Pushmeet Kohli and Matej Balog tell No Priors how an evolutionary coding agent searches algorithm space the way AlphaGo searched Go.
40:33ENSequoia Capital· Jun 24, 2025PodcastFifty People in Slack. Four Minutes to the Smoking Gun.Traversal's co-founders on turning DevOps heart attacks into agent-run root cause analysis — and why observability's second-largest software spend still leaves troubleshooting as a whodunit.
38:48ENCognitive Revolution "How AI Changes Everything"· Jun 14, 2025PodcastTask Length Doubles Every Few Months. Nathan Labenz Still Wants Humans in ChargeHost Nathan LabenzAt Imagine AI Live, the Cognitive Revolution host maps structured AI agents against autonomous agentic systems—and tells businesses to keep final control.
41:25ENNo Priors: AI, Machine Learning, Tech, & Startups· Jun 12, 2025Podcast · 2 speakersBen Mann thinks superintelligence by 2028 is quite possibleHost Sarah Guo, Elad GilAnthropic's co-founder tells No Priors how Claude 4 unlocked hours of unattended agent work, why the lab built Claude Code, and what an economic Turing test would actually measure.
38:25ENSequoia Capital· May 27, 2025PodcastA thousand airplanes will never train an AI engineerFormer Airbus CTO Paul Eremenko explains why physical-world engineering still has no coding-AI moment, and how P-1 AI's agent Archie is supposed to get there anyway.
1:01:51ENCognitive Revolution "How AI Changes Everything"· May 22, 2025PodcastClaude 3.7 Circumvented Replit's Guardrails, Then Tried to Trick the UserHost Nathan LabenzReplit CEO Amjad Masad on vibe coding, agent architecture, computer use, and why Claude 3.7 is too autonomous to serve as a polite assistant.
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Unsupervised Learning: With Jacob Effron· May 22, 2025PodcastThe New Ruler for Models Is How Long They Can WorkHost Jacob EffronOn Claude 4's launch day, Anthropic researcher Sholto Douglas argued that the next phase of AI is less about harder puzzles and more about hours of unsupervised work.
47:00ENUnsupervised Learning: With Jacob Effron· May 8, 2025PodcastAn Eval Lasts Three Months — and a Frozen Frontier Would Still Feed Startups for a DecadeHost Jacob EffronOpenAI’s GPT-4.1 post-training lead Michelle Pokrass tells Unsupervised Learning how the team spent three months on evals before training, why agents fail on wiring more than intelligence, and when to reach for RFT.
38:10ENNo Priors: AI, Machine Learning, Tech, & Startups· May 1, 2025Podcast · 2 speakerso3 should wait exactly as long as the answer takesHost Sarah Guo, Elad GilOpenAI researchers Eric Mitchell and Brandon McKinzie tell No Priors why o3's leap is a chain of tools during reasoning — and why you should send the same prompt a hundred times.
30:46ENNo Priors: AI, Machine Learning, Tech, & Startups· Apr 24, 2025Podcast · 2 speakersDeep Research Turned Web Browsing into a Trainable ProblemHost Sarah Guo, Elad GilOpenAI researcher Isa Fulford explains why a side project on read-only synthesis became an agent, when reinforcement fine-tuning is worth it, and why models will hack the search engine you gave them.
41:52ENNo Priors: AI, Machine Learning, Tech, & Startups· Apr 10, 2025Podcast · 2 speakersMercor Hit $100 Million ARR Teaching Models to Hire. Humans Now Write the Exams.Host Sarah Guo, Elad GilBrendan Foody tells Sarah Guo and Elad Gil how Mercor automated recruiting for frontier labs — and why building evals may become the world's most common knowledge job.
1:26:21ENCognitive Revolution "How AI Changes Everything"· Apr 10, 2025PodcastFor under $10, Google's AI independently recovered a lab result nobody had publishedHost Nathan LabenzVivek Natarajan and Anil Palepu tell Nathan Labenz how AMIE beats primary-care doctors on treatment plans, and how Co-Scientist matched Imperial College's unpublished bacterial-resistance mechanism.
1:26:19ENSequoia Capital· Apr 8, 2025PodcastHe turned down a billion dollars for a world with a billion developersReplit CEO Amjad Masad tells Sequoia’s Training Data why a six-person company walked away from a life-changing offer, and why a billion people writing software is a better end state than AGI as universal basic income.
2:14:59ENCognitive Revolution "How AI Changes Everything"· Mar 29, 2025PodcastAlways Bet on the Models: How Shortwave's Andrew Lee Shipped Tasklet as Agents All the Way DownHost Nathan LabenzThe Firebase co-founder argues that workflow software is already obsolete, that MCP is optional, and that the only durable advantage left for an AI startup is speed.
1:01:53ENUnsupervised Learning: With Jacob Effron· Mar 28, 2025PodcastOpen-source models are 5% of enterprise use — and GPT wrappers wonHost Jacob EffronLatent Space's Swyx and Alessio join Redpoint to map what actually has product-market fit in AI, and why the application layer is the fight that matters.
1:25:12ENCognitive Revolution "How AI Changes Everything"· Mar 27, 2025PodcastHe Hasn’t Typed a Line of Code in Months. Here’s How Augment Reads a Million-Line RepoHost Nathan LabenzGuy Gur-Ari, co-founder and chief scientist at Augment, tells Nathan Labenz how coding agents actually work inside messy enterprise codebases.
43:04ENSequoia Capital· Mar 25, 2025Podcast750 Million Excel Users, 30 Million Engineers: Wordware's Bet on Word ArtisansFilip Kozera tells Sequoia why English is the assembly language of LLMs, and why the people who win will be the ones who can encode taste into structured prompts.
50:35ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 13, 2025Podcast · 2 speakersCopilot Already Writes Half the Code. GitHub's CEO Says Agents Still Have Four Gates to ClearHost Sarah Guo, Elad GilThomas Dohmke on agent mode, why median developers are not going anywhere, and how AI is repricing the tools that write software.Load moreShowing 24 of 137