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1:22:04ENElevenLabs CEO Mati Staniszewski on Voice AI, Growth and Building from EuropeGuest Mati Staniszewski · Host Harry StebbingsStaniszewski discusses the company’s origins in dubbing, its financing and reported ARR, and the challenges of scaling voice products.
44:49ENHow OpenEvidence Became the Clinical OS for 40% of U.S. DoctorsHost Sarah Guo, Elad GilFounder Daniel Nadler tells No Priors how a free search tool for physicians, not an answer engine for patients, took high-stakes clinical knowledge in 18 months.
1:12:58ENChris Lattner on Mojo and the Search for Portable GPU PerformanceYaron Minsky, Chris Lattner · Jane StreetRon Minsky and Chris Lattner discuss the language and compiler design behind Modular’s effort to make accelerator programming both portable and fast.
3:36:25ENT. rex Was an Orca on Land. Almost Nothing Else Matches the Movies.Guest Dave Hone · Host Lex FridmanPaleontologist Dave Hone walks Lex Fridman through T. rex size, bone-crushing anatomy, hunting, extinction, and what Jurassic Park still gets wrong.
1:14:39ENNick Frosst on Cohere’s Enterprise AI Strategy and the Limits of HypeGuest Nick Frosst · Host Harry StebbingsThe Cohere co-founder discusses data, benchmarks, workplace automation and why he challenges popular claims about AGI.
1:50:28ENThe 87-Kilobyte Program Two Billion People Open Every MonthGuest Dave Plummer · Host Lex FridmanDave Plummer talks Lex Fridman through Task Manager, old-school Microsoft, and how an autistic mind actually works.
40:54ENSeventeen Years of Flat Power, and a Plan to Bring the Factories HomeHost Sarah Guo, Elad GilJacob Helberg, the under secretary of state designate for economic growth, energy, and the environment, argues that nuclear power and AI productivity—not cheap labor—are how America reshore its supply chain.
1:01:23ENWill Crichton on Making Rust More UnderstandableWill Crichton · Brown UniversityOwnership visualizations, interactive trait diagnostics and program slicing illustrate an evidence-based approach to developer tools.
20:05ENAI News: Macrohard, Comet Plus and the Debate Over AI WelfareMatthew Berman, Dara Khosrowshahi · Forward FutureMatthew Berman reviews August 2025 AI news, from generative worlds and publisher payments to robotics, Intel and enterprise AI results.
1:23:11ENBessemer’s Byron Deeter on AI Growth, Venture Scale and LiquidityGuest Byron Deeter · Host Harry StebbingsDeeter discusses AI software economics, follow-on investments and the trade-offs facing venture firms and their limited partners.
10:26:31ENThe War on Terror's Only Gift Was Better Luke Skywalker HandsGuest Scott Horton · Host Lex FridmanScott Horton walks Lex Fridman through fifty years of U.S. wars, from Vietnam Syndrome to Ukraine, and argues the machinery never stops because it is not supposed to.
42:12ENHire the AI First: Andrew Ng on Agentic Workflows and the Scarcity of JudgmentHost Sarah Guo, Elad GilOn No Priors, Andrew Ng argues that agentic AI has made software cheap and fast, which moves the bottleneck to product judgment, error analysis, and the instinct to try an AI before adding headcount.
1:14:08ENLovable CEO Anton Osika on AI App Building, Economics and SecurityGuest Anton Osika · Host Harry StebbingsOsika discusses Lovable’s reported growth, model costs and product strategy while Stebbings challenges its defensibility and security.
1:09:11ZH → EnglishGuang Mi on the Diverging Paths of Large Models, AI Products, and the Startup WindowGuest 广密 · Host 张小珺Guang Mi reviews how model companies are splitting into different strategies, the brand moat around ChatGPT, and new opportunities opened by products such as Claude Code. He believes the window for AI startups is shrinking, but great product experiences, sound team judgment, and non-consensus innovation can still create room to win.
13:30ENHow AlphaGeometry Combines Logical Proof with Creative ConstructionAleph0Aleph0 explains how a symbolic geometry solver gets surprisingly far without AI, and how a language model supplies the auxiliary constructions that take it to Olympiad level.
47:18ENThe Analyst Tracking 200 GPU Clouds Breaks Nvidia Into a Three-Headed DragonHost Sarah Guo, Elad GilSemiAnalysis founder Dylan Patel on OpenAI’s open-weight model, a coming neocloud wipeout, and why a chip startup has to beat Nvidia on hardware, networking, and software at once.
1:49:29ENChina Is Not Run by One Person. It Is a Mayor EconomyGuest Keyu Jin · Host Lex FridmanEconomist Keyu Jin on local GDP races, DeepSeek, tariffs, Jack Ma, and why Western collapse forecasts keep missing the country they describe.
1:22:51ENMartin Mignot on Index Ventures, Revolut and Investing in FoundersGuest Martin Mignot · Host Harry StebbingsThe Index Ventures partner explains how he evaluates early-stage companies, manages concentrated returns and learns from missed opportunities.
45:17ENA Click From OpenAI Is 750 Times Harder Than From Google a Decade AgoHost Sarah Guo, Elad GilCloudflare CEO Matthew Prince on Content Independence Day, why traffic is a broken proxy for value, and how to price the holes in the models.
40:32ENMark Chen on GPT-5, Synthetic Data and the Future of AI ResearchMatthew Berman, Mark Chen · Forward FutureOpenAI’s head of research discusses training, agents, open-weight releases and evaluation with Matthew Berman in August 2025.
1:30:36ENMiles Dieffenbach on Endowment Investing, Venture Returns and LiquidityGuest Miles Dieffenbach · Host Harry StebbingsThe Carnegie Mellon allocator explains how he compares venture funds with public markets and evaluates fund size, fees and private marks.
36:48ENThe Weekend DeepSeek Dropped, the White House CalledHost Sarah Guo, Elad GilSriram Krishnan walks No Priors through America’s 28-page AI Action Plan, a token-share definition of winning, and why the lead over China is too small to take for granted.
4:30:02ENGenghis Khan Never Fought a Battle He Thought He Could LoseGuest Jack Weatherford · Host Lex FridmanAnthropologist Jack Weatherford tells Lex Fridman how an abandoned boy on the Mongolian steppe built the largest contiguous empire in history—and why conquest is only part of the story.
1:16:25ENMartin Casado on AI Models, Open Technology and Venture CompetitionGuest Martin Casado · Host Harry StebbingsThe Andreessen Horowitz partner discusses coding tools, open-model policy, labor disruption and how his firm evaluates investments.
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