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44:44EN
No Priors: AI, Machine Learning, Tech, & Startups· Jul 10, 2025Podcast · 2 speakers$1 of R&D, 35x the return: why Parker Conrad says platforms beat point solutionsHost Sarah Guo, Elad GilThe Rippling CEO on Zenefits, founder psychology, and why shared underlying capabilities—not narrow focus—win in enterprise software.
49:27ENNo Priors: AI, Machine Learning, Tech, & Startups· Jul 3, 2025Podcast · 2 speakersFrom 0.1% to 20%: Chai-2 Turns Antibody Design Into Prompt EngineeringHost Sarah Guo, Elad GilChai Discovery co-founders Joshua Meier and Jack Dent tell Sarah Guo how a generative model now designs antibodies that bind on the first 24-well plate.
42:09ENNo Priors: AI, Machine Learning, Tech, & Startups· Jun 26, 2025Podcast · 2 speakersAlphaEvolve found algorithms humans missed for 50 years — then sped up Gemini 23%Host Sarah Guo, Elad GilGoogle DeepMind’s Pushmeet Kohli and Matej Balog tell No Priors how an evolutionary coding agent searches algorithm space the way AlphaGo searched Go.
45:21ENNo Priors: AI, Machine Learning, Tech, & Startups· Jun 17, 2025Podcast · 2 speakersApplied Intuition Is Worth $15 Billion, Hasn't Spent Its Capital, and Wants to Be the OS for Cars and TanksHost Sarah Guo, Elad GilOn No Priors, Qasar Younis and Peter Ludwig explain the Microsoft playbook for vehicles, why they waited for autonomy techniques to converge, and why Waymo's business model is the question that follows the demo.
41:25ENNo Priors: AI, Machine Learning, Tech, & Startups· Jun 12, 2025Podcast · 2 speakersBen Mann thinks superintelligence by 2028 is quite possibleHost Sarah Guo, Elad GilAnthropic's co-founder tells No Priors how Claude 4 unlocked hours of unattended agent work, why the lab built Claude Code, and what an economic Turing test would actually measure.
35:47ENNo Priors: AI, Machine Learning, Tech, & Startups· Jun 5, 2025Podcast · 2 speakersFei-Fei Li’s new bet: AI is incomplete without spatial intelligenceHost Sarah Guo, Elad GilThe ImageNet pioneer tells Sarah Guo and Elad Gil why World Labs is building 3D generative foundation models, and why language was only one piece of the puzzle.
31:34ENNo Priors: AI, Machine Learning, Tech, & Startups· May 15, 2025Podcast · 2 speakersOne Company Now Holds as Many Documents as the Entire Early WebHost Sarah Guo, Elad GilGlean CEO Arvind Jain tells No Priors why enterprise search was a graveyard, how transformers finally made it work, and why a product that searches too well can be too dangerous to sell.
32:15ENNo Priors: AI, Machine Learning, Tech, & Startups· May 8, 2025Podcast · 2 speakersThe Hardest Part of Learning Is Getting Yourself to StartHost Sarah Guo, Elad GilDuolingo CEO Luis von Ahn tells Sarah Guo how two-minute lessons, streaks, an 83 percent accuracy target, and large language models turned language study into a consumer product.
38:10ENNo Priors: AI, Machine Learning, Tech, & Startups· May 1, 2025Podcast · 2 speakerso3 should wait exactly as long as the answer takesHost Sarah Guo, Elad GilOpenAI researchers Eric Mitchell and Brandon McKinzie tell No Priors why o3's leap is a chain of tools during reasoning — and why you should send the same prompt a hundred times.
30:46ENNo Priors: AI, Machine Learning, Tech, & Startups· Apr 24, 2025Podcast · 2 speakersDeep Research Turned Web Browsing into a Trainable ProblemHost Sarah Guo, Elad GilOpenAI researcher Isa Fulford explains why a side project on read-only synthesis became an agent, when reinforcement fine-tuning is worth it, and why models will hack the search engine you gave them.
40:54ENNo Priors: AI, Machine Learning, Tech, & Startups· Apr 17, 2025Podcast · 2 speakersDiscovery rates collapsed tenfold. KoBold still found a 5% copper depositHost Sarah Guo, Elad GilJosh Goldman explains why KoBold Metals treats mineral exploration as an information problem, pairing AI with century-old maps to hunt lithium and copper.
41:52ENNo Priors: AI, Machine Learning, Tech, & Startups· Apr 10, 2025Podcast · 2 speakersMercor Hit $100 Million ARR Teaching Models to Hire. Humans Now Write the Exams.Host Sarah Guo, Elad GilBrendan Foody tells Sarah Guo and Elad Gil how Mercor automated recruiting for frontier labs — and why building evals may become the world's most common knowledge job.
38:43ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 27, 2025Podcast · 2 speakersTwo in Five Doctors Want Out. An On-Call Cardiologist Built the Note That Lets Them StayHost Sarah Guo, Elad GilAbridge CEO Shiv Rao on treating the doctor-patient conversation as healthcare's source of truth, and why the company ran straight at the hardest health systems.
35:14ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 20, 2025Podcast · 2 speakersRobots Have No Wikipedia. Chelsea Finn Is Starting With Three Buildings.Host Sarah Guo, Elad GilPhysical Intelligence’s cofounder tells No Priors why a generalist robot model has to be trained across embodiments, why open-sourcing hardware is a bet against the problem going unsolved, and why humanoids are a little overrated.
50:35ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 13, 2025Podcast · 2 speakersCopilot Already Writes Half the Code. GitHub's CEO Says Agents Still Have Four Gates to ClearHost Sarah Guo, Elad GilThomas Dohmke on agent mode, why median developers are not going anywhere, and how AI is repricing the tools that write software.
36:24ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 5, 2025Podcast · 2 speakersThe Man Behind Humanity's Last Exam Says Superintelligence Strategy Should Copy NukesHost Sarah Guo, Elad GilDan Hendrycks tells No Priors that labs can only do basic anti-terror refusals, while the real risk-management problem is a geopolitical deterrent he calls mutually assured AI malfunction.
40:33ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 27, 2025Podcast · 2 speakersModerna was only company 18. The real product is the company factoryHost Sarah Guo, Elad GilNoubar Afeyan tells No Priors how Flagship Pioneering turned starting companies into a profession, underwrites scientific uncertainty, and wants AI to run discovery the way Waymo drives.
57:41ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 25, 2025Podcast · 2 speakersA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentHost Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
38:14ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 20, 2025Podcast · 2 speakersKyle Vogt Pitched 120 Investors for Cruise. He Will Not Sell the Home-Robot CompanyHost Sarah Guo, Elad GilThe Twitch and Cruise co-founder tells Sarah Guo and Elad Gil why Tesla won on business model, why chores should be automated, and why a tiny AI-era team is enough.
49:36ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 14, 2025Podcast · 2 speakers86 Out of 100: Harvey's Playbook for Selling AI Into LawHost Sarah Guo, Elad GilWinston Weinberg on a Reddit blind test, expanding-and-collapsing product design, and why Harvey started with century-old firms instead of the mid-market.
37:58ENNo Priors: AI, Machine Learning, Tech, & Startups· Jan 23, 2025Podcast · 2 speakersThe Forest Will Burn. The Only Question Is on Whose Terms.Host Sarah Guo, Elad GilConvective Capital’s Bill Clerico walks through why California’s wildfires reached a crescendo, and which wounds are still self-inflicted enough to fix.
30:09ENNo Priors: AI, Machine Learning, Tech, & Startups· Jan 16, 2025Podcast · 2 speakersBilt Saved 65 Support Seats. Decagon's Founder Says Most Agent Ideas Still Won't SellHost Sarah Guo, Elad GilJesse Zhang on why customer support is the golden agent use case, why instruction following beats o1-style reasoning, and the two filters that kill most agent startups.
31:18ENNo Priors: AI, Machine Learning, Tech, & Startups· Dec 19, 2024Podcast · 2 speakersElias Torres sold a billion-dollar company and called it a failure. Agency is the redo.Host Sarah Guo, Elad GilThe Drift founder wants $1 billion in revenue with 100 people, one email address, and software that works like a text to someone who actually shows up.
42:21ENNo Priors: AI, Machine Learning, Tech, & Startups· Dec 12, 2024Podcast · 2 speakersThey Cooled 5,000 Watts per Square Centimeter in Space. Now Diamond Goes on AI ChipsHost Sarah Guo, Elad GilAkash Systems founders Felix Ejeckam and Ty Mitchell tell Sarah Guo why heat is the real limiter on AI, and how lab-grown diamond bonded to semiconductors is their answer.Load moreShowing 24 of 156