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59:46ENIn Young Cho on Trading Research and Finding Signal in Financial DataRon Minsky, In Young Cho · Jane StreetIn Young Cho and Ron Minsky discuss the blurred lines between trading, research, and engineering, and why machine learning in markets is difficult.
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Sequoia Capital· Feb 25, 2025PodcastDon't draw the flowchart: OpenAI's Deep Research team on training agents end to endIsa Fulford and Josh Tobin explain why Deep Research was trained with reinforcement learning on hard browsing tasks instead of a human-written graph of model calls.
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No Priors: AI, Machine Learning, Tech, & Startups· Feb 25, 2025Podcast · 2 speakersA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentHost Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
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Cognitive Revolution "How AI Changes Everything"· Jan 22, 2025PodcastTwenty-atom crystals taught an AI the physics of a heartbeatHost Nathan LabenzOrbital Materials' Jonathan Godwin and Tim Duignan tell Nathan Labenz how a neural network trained on tiny crystals simulated a potassium ion channel on a single 2017 GPU.
1:27:33ENCognitive Revolution "How AI Changes Everything"· Dec 3, 2024PodcastA 70B Model Booked Dinner 20% of the Time. MultiOn Took It to 95% in a DayHost Nathan LabenzMultiOn CEO Div Garg returns to The Cognitive Revolution to recap 18 months of agent hype, the AgentQ stack, and why 2025 might still be the year of vertical agents.
1:49:41ENCognitive Revolution "How AI Changes Everything"· Nov 21, 2024PodcastA Team of Fifteen Matched Meta’s Post-Training on Meta’s Own BaseHost Nathan LabenzNathan Lambert walks through Tulu 3: the three-stage recipe, the 1 percent versus 14 percent lesson, and why open post-training now lives or dies on data and evals.
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Unsupervised Learning: With Jacob Effron· Oct 29, 2024PodcastDeepL Beat Google at Translation by Refusing to Be a General ModelHost Jacob EffronOnly 18 percent of the world speaks English—and a Cologne startup turned that fact into a $2 billion language-AI company.
1:13:23ENCognitive Revolution "How AI Changes Everything"· Oct 12, 2024PodcastAn AI Found a GABA-Cancer Link. The Next Step Is Talking to the Cells.Host Nathan LabenzMichael Levin and Leo Pio Lopez on a multilayer embedding that predicted melanoma, a cancer with no mutations, and why biology's real interface is cognitive.
59:30ENSequoia Capital· Oct 8, 2024PodcastGPT-4 Gets Half Your Data Questions Wrong. Snowflake's Answer Is Systems DesignUsing an off-the-shelf model on enterprise data yields about 45% reliability—one wrong answer out of every two.
35:30ENReflection 70B: Its Creators Explain the Proposed Self-Correction MethodMatthew Berman, Matt Shumer, Sahil Chaudhary · Forward FutureA launch-day discussion with Matt Shumer and Sahil Chaudhary covers synthetic data, selective reflection and evaluation limits.
50:33ENSequoia Capital· Aug 20, 2024PodcastThe 40% data-center save started with an email that ended in a question markPhaidra founder Jim Gao tells Sequoia how an AlphaGo-inspired bet at Google became reinforcement learning that runs billion-dollar plants.
1:16:11ENCognitive Revolution "How AI Changes Everything"· Jul 11, 2024PodcastScooping Food Into Boxes Is 70 Percent of Plant LaborHost Nathan LabenzChef Robotics CEO Rajat Bhageria on 20 million plated meals, a foundation model for food, and why the kitchen may leave the house.
1:00:28ENSequoia Capital· Jul 9, 2024PodcastScaling Laws Aren't Done. Don't Lock Yourself Into Yesterday's Architecture.Microsoft CTO Kevin Scott on why the exponential is still compounding, why inference will dwarf training, and why a language model is the world's crappiest database.
39:00ENNo Priors: AI, Machine Learning, Tech, & Startups· May 22, 2024Podcast · 2 speakersJPMorgan Has 150 Petabytes. GPT-4 Trained on Less Than One.Host Sarah Guo, Elad GilScale AI founder Alexandr Wang tells No Priors why easy internet data is exhausted, why expert-plus-model teams still win, and why the path to AGI looks more like curing cancer than inventing a vaccine.
1:01:39ENCognitive Revolution "How AI Changes Everything"· Apr 13, 2024PodcastGPT-5 Wants 100 Trillion Tokens. Does Earth Have Enough?Host Nathan LabenzTraining GPT-3 took about a trillion tokens; GPT-4 took about ten trillion. The next jump is a data question as much as a compute one.
38:48ENNo Priors: AI, Machine Learning, Tech, & Startups· Jan 31, 2024Podcast · 2 speakersShopify Built a Copilot, Not an Autopilot, for Every MerchantHost Sarah Guo, Elad GilShopify VP of Core Product Glen Coates on collapsing duplicate engines, shipping AI that proposes but never commits, and teaching storefront search to understand a sweater.
40:58ENNo Priors: AI, Machine Learning, Tech, & Startups· Jan 25, 2024Podcast · 2 speakers99% of Factory Robots Are Dumb. Covariant Wants the Smart Ones Working in Warehouses FirstHost Sarah Guo, Elad GilFormer OpenAI researcher Peter Chen explains why robot foundation models have to be trained on production floors, not in labs.
27:14ENNo Priors: AI, Machine Learning, Tech, & Startups· Dec 7, 2023Podcast · 2 speakersSeven People Did the Work of 700. Salesforce's AI Chief Says Enterprise AI Is Still in the Second InningHost Sarah Guo, Elad GilClara Shih tells Sarah Guo and Elad Gil why Salesforce built a shared LLM platform, why data cleanup beats model shopping, and why AI is becoming the enterprise UI.
1:21:50ENCognitive Revolution "How AI Changes Everything"· Nov 14, 2023PodcastA 16K Context Window Holds About 350 Rows. That's Why Tables Need an Agent.Host Nathan LabenzGretel AI founder Alex Watson tells Nathan Labenz why most company data is still a spreadsheet, why GPT-4 is the wrong tool for generating it, and how differential privacy lets a model learn a disease without learning a patient.
1:32:40ENCognitive Revolution "How AI Changes Everything"· Oct 31, 2023PodcastThe Historian Who Taught GPT-3.5 to Beat GPT-4Host Nathan LabenzMark Humphries on a kilometer of unread paper, fur-trade jargon that embeddings cannot see, and why cheap processing will force history to be rewritten.
37:01ENNo Priors: AI, Machine Learning, Tech, & Startups· Sep 28, 2023Podcast · 2 speakersDNA Is Code, but You Compile It with a PipetteHost Sarah Guo, Elad GilGinkgo Bioworks CEO Jason Kelly tells No Priors why cells are worth the magic, why biology has no AWS, and why a pandemic should look like cybersecurity.
2:15:11ENCognitive Revolution "How AI Changes Everything"· Sep 22, 2023PodcastTwenty Gibberish Tokens Jailbroke ChatGPT and BardHost Nathan LabenzCarnegie Mellon’s Zico Kolter, Andy Zou, and Asher Trockman walk through a universal jailbreak that transfers from open models to commercial APIs, and a training-free way to steal some of pretraining’s benefit.
51:22ENNo Priors: AI, Machine Learning, Tech, & Startups· Jun 29, 2023Podcast · 2 speakersThree IPOs Later, Frank Slootman Still Thinks the Job Is UrgencyHost Sarah Guo, Elad GilSnowflake's CEO tells No Priors how he picked the right elevator, turned a 15-person backup startup into an EMC acquisition, and why a data lake is a landfill you should not train on.
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Lex Fridman· Jun 18, 2023Podcast · 2 speakersWikipedia Worked Once Writing Stopped Feeling Like Grad SchoolGuest Jimmy Wales · Host Lex FridmanJimmy Wales tells Lex Fridman how Nupedia's seven-stage review died, why Wikipedia still refuses ads and governments, and what large language models should actually do with an encyclopedia.Load moreShowing 24 of 79