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40:33EN
No Priors: AI, Machine Learning, Tech, & Startups· Feb 27, 2025Podcast · 2 speakersModerna was only company 18. The real product is the company factoryHost Sarah Guo, Elad GilNoubar Afeyan tells No Priors how Flagship Pioneering turned starting companies into a profession, underwrites scientific uncertainty, and wants AI to run discovery the way Waymo drives.
57:41ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 25, 2025Podcast · 2 speakersA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentHost Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
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Cognitive Revolution "How AI Changes Everything"· Jan 22, 2025PodcastTwenty-atom crystals taught an AI the physics of a heartbeatHost Nathan LabenzOrbital Materials' Jonathan Godwin and Tim Duignan tell Nathan Labenz how a neural network trained on tiny crystals simulated a potassium ion channel on a single 2017 GPU.
1:01:53ENCognitive Revolution "How AI Changes Everything"· Dec 18, 2024PodcastHumans Wrote 1.3 Percent of the Tokens. The AI Lab Still Designed Working Nanobodies.Host Nathan LabenzStanford's James Zou describes a GPT-4o research group that invented a protein-design pipeline for under $100 — and a sparse autoencoder that pulled an undocumented motif out of ESM-2.
1:55:53ENCognitive Revolution "How AI Changes Everything"· Dec 5, 2024PodcastAI Beats Humans at Reading Papers. It Still Cannot Count Atoms.Host Nathan LabenzAndrew White, Head of Science at Future House, maps what language models can already do in chemistry and biology—and the bottlenecks they do not dissolve.
39:22ENNo Priors: AI, Machine Learning, Tech, & Startups· Nov 14, 2024Podcast · 2 speakersA Fields Medalist Stuck for Two Hours. AlphaProof Climbed for Three Days.Host Sarah Guo, Elad GilThe DeepMind team behind AlphaProof tells Sarah Guo and Elad Gil how an AlphaZero-style agent, a Lean verifier, and test-time reinforcement learning reached IMO silver — and why the missing skill is still theory building.
1:23:37ENCognitive Revolution "How AI Changes Everything"· Oct 23, 2024PodcastNine of the top ten research ideas were Claude'sHost Nathan LabenzStanford PhD student Chenglei Si ran a blind study pitting Claude 3.5 Sonnet against more than a hundred NLP researchers on novel research ideas.
41:42EN
Sequoia Capital· Oct 22, 2024PodcastNeural Networks Are Still Waiting for Their ThermodynamicsOpenAI researcher Dan Roberts on why physicists keep migrating into AI, and why the field still lacks the equivalent of the ideal gas law.
1:13:23ENCognitive Revolution "How AI Changes Everything"· Oct 12, 2024PodcastAn AI Found a GABA-Cancer Link. The Next Step Is Talking to the Cells.Host Nathan LabenzMichael Levin and Leo Pio Lopez on a multilayer embedding that predicted melanoma, a cancer with no mutations, and why biology's real interface is cognitive.
39:45ENSequoia Capital· Sep 24, 2024PodcastHarmonic’s Bet: Teach AI Math Directly, and the Riemann Hypothesis Falls by 2029Robinhood’s Vlad Tenev and Harmonic co-founder Tudor Achim tell Sequoia why math is reasoning, why Lean is the verifier, and why they refuse to wait for mathematical skill to emerge from scale.
1:18:32ENCognitive Revolution "How AI Changes Everything"· Sep 20, 2024PodcastA DNA Model That Can Tell Which Genes You Cannot TouchHost Nathan LabenzStanford's Brian Hie walks through hybrid architectures, a genome-scale language model trained only on DNA, and an antibody that binds 25 times tighter than nature.
1:54:01ENCognitive Revolution "How AI Changes Everything"· Jun 26, 2024PodcastA Tiny Network Grew a Salt Crystal the Training Data Never ShowedHost Nathan LabenzTim Duignan trained tens of thousands of parameters on salt water. The model invented a crystal — and a continuum solvent theory he had spent a PhD failing to write by hand.
1:59:15ENCognitive Revolution "How AI Changes Everything"· May 25, 2024PodcastA Protein Backbone in a Minute: The Real Progress, Bottlenecks, and Risks of AI BiologyHost Nathan LabenzThe White House set a thousand-fold lower reporting bar for biological models than for language models—and this conversation shows why that gap already looks prescient.
1:20:44ENCognitive Revolution "How AI Changes Everything"· Mar 30, 2024PodcastSeeing Like a Mamba: Vision, Rotting States, and a Cell Model in 90 DaysHost Nathan LabenzNathan Labenz and Jason Meaux survey the vision papers, long-context experiments, and biology work that followed the original Mamba release.
1:25:09ENCognitive Revolution "How AI Changes Everything"· Feb 9, 2024PodcastTwo-Headed Worms, Regenerated Legs, and a Sort That Learned to WaitHost Nathan LabenzTufts biologist Michael Levin tells Cognitive Revolution why anatomy is rewritable software, and why he stopped a paper that might have made AI more alive.
1:50:57ENCognitive Revolution "How AI Changes Everything"· Jan 12, 2024PodcastTwenty-Eight Days After GPT-4, an AI Designed and Ran a Chemistry ExperimentHost Nathan LabenzGabe Gomes and his Carnegie Mellon students built Coscientist, a language-model agent that plans, codes, and executes real experiments on a remote cloud lab.
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Lex Fridman· Dec 9, 2023Podcast · 2 speakersComplexity without copies is just randomness: Lee Cronin on assembly theoryGuest Lee Cronin · Host Lex FridmanThe Glasgow chemist walks Lex Fridman through his controversial Nature paper, a proposed life meter for other worlds, and the claim that the universe is too big to contain its own future.
37:01ENNo Priors: AI, Machine Learning, Tech, & Startups· Sep 28, 2023Podcast · 2 speakersDNA Is Code, but You Compile It with a PipetteHost Sarah Guo, Elad GilGinkgo Bioworks CEO Jason Kelly tells No Priors why cells are worth the magic, why biology has no AWS, and why a pandemic should look like cybersecurity.
2:18:25ENLex Fridman· Sep 1, 2023Podcast · 2 speakersGrow Everything: Neri Oxman on Giving Nature a VoteGuest Neri Oxman · Host Lex FridmanThe designer-scientist who left MIT to build OXMAN talks silkworm pavilions, bees in space, and why the end of human agency might be the start of nature's.
35:24ENNo Priors: AI, Machine Learning, Tech, & Startups· Aug 24, 2023Podcast · 2 speakersThe Author of Attention Is All You Need Now Compiles mRNA Like BytecodeHost Sarah Guo, Elad GilJakob Uszkoreit on why Transformers won, why models spend compute on the wrong things, and why drug discovery has to become generation rather than screening.
2:07:04ENLex Fridman· May 28, 2023Podcast · 2 speakersThe Ribosome Already Solved Digital ManufacturingGuest Neil Gershenfeld · Host Lex FridmanNeil Gershenfeld tells Lex Fridman why Turing separated the head from the tape, how fab labs are the personal-computer moment for making things, and what it would take to grow a civilization from about twenty parts.
46:57ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 2, 2023Podcast · 2 speakers95% of Drug Programs Fail. Daphne Koller Is Betting Machine Learning on the First DecisionHost Sarah Guo, Elad GilA new medicine still takes more than a decade and well over a billion dollars — and Insitro's founder argues the expensive failures start with the wrong target, indication, or patient.
2:06:25ENLex Fridman· Dec 19, 2022Podcast · 2 speakersNathalie Cabrol Wants the Nature of Life, Not Just a Signal from MarsGuest Nathalie Cabrol · Host Lex FridmanThe SETI Institute astrobiologist tells Lex Fridman why crater lakes, panspermia, and a Mandelbrot view of language all point to the same question: what life actually is.
3:43:01ENLex Fridman· Sep 7, 2022Podcast · 2 speakersPut Hydrogen and CO2 in a Tube. Thermodynamics Wants Cells. Nothing Happens.Guest Nick Lane · Host Lex FridmanBiochemist Nick Lane talks Lex Fridman through hydrothermal vents, mitochondria, sex, consciousness, and why bacteria should be common while civilizations are not.Load moreShowing 24 of 69