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1:18:18EN
Cognitive Revolution "How AI Changes Everything"· Jun 20, 2023PodcastFifteen Thousand Brain Numbers Were Enough to Reconstruct What Someone SawHost Nathan LabenzTanishq Mathew Abraham walks through MindEye, the fMRI-to-image system that maps a handful of voxel values onto CLIP and diffusion models.
1:25:35ENCognitive Revolution "How AI Changes Everything"· May 21, 2023PodcastTwo and a Half Years From 33.3% to 86.5%: Google Sent Foundation Models to Medical SchoolHost Nathan LabenzVivek Natarajan walks Nathan Labenz through Med-PaLM and Med-PaLM 2: the data-light techniques, the nine-axis clinician evals, and why a high USMLE-style score is the wrong trophy.
42:18EN
No Priors: AI, Machine Learning, Tech, & Startups· May 18, 2023Podcast · 2 speakersTen Percent of Search Is Health — and the Doctor Is Googling TooHost Sarah Guo, Elad GilGoogle researcher Karan Singhal on Med-PaLM 2, the real bar for medical language models, and why medicine is a harder alignment lab than chatbots.
1:28:43ENCognitive Revolution "How AI Changes Everything"· May 16, 2023PodcastClinical Guidelines Are 11% Evidence. Curai’s Founder Still Wants GPT-4 in the Exam RoomHost Nathan LabenzNeal Khosla of Curai Health argues that large language models already match median U.S. physicians on today’s tests — and that the real work is scaffolding, supervision, and a doctor’s signature.
58:24ENCognitive Revolution "How AI Changes Everything"· May 11, 2023PodcastAmong 100 Random Doctors, Zak Kohane Would Be Surprised If One Beat GPT-4Host Nathan LabenzHarvard's biomedical informatics chair on a rare newborn case, why drug-style trials will not certify a general medical model, and why the AI should still work for the patient.
46:57ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 2, 2023Podcast · 2 speakers95% of Drug Programs Fail. Daphne Koller Is Betting Machine Learning on the First DecisionHost Sarah Guo, Elad GilA new medicine still takes more than a decade and well over a billion dollars — and Insitro's founder argues the expensive failures start with the wrong target, indication, or patient.
50:12ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 20, 2023Podcast · 2 speakersThe Drone Is Only 15 Percent of the ProblemHost Sarah Guo, Elad GilZipline CEO Keller Rinaudo Cliffton on why blood delivery in Rwanda, not a cooler airplane, built the world's largest commercial autonomous system.
2:43:51EN
Lex Fridman· Jun 25, 2022Podcast · 2 speakersTwo Tubes, Millimeters Apart: Jonathan Reisman on the Honest Design of the Human BodyGuest Jonathan Reisman · Host Lex FridmanThe emergency physician and author of The Unseen Body walks Lex Fridman from the throat to the Arctic, arguing that anatomy is mostly brilliant, sometimes a near-miss, and always a story written in scars.
3:21:29ENLex Fridman· Apr 7, 2022Podcast · 2 speakersWhen something in the mind breaks, you see what it was forGuest Karl Deisseroth · Host Lex FridmanStanford psychiatrist Karl Deisseroth talks with Lex Fridman about depression, schizophrenia, optogenetics, and why you can treat one symptom without a theory of everything.
1:41:34ENLex Fridman· Jun 6, 2021Podcast · 2 speakersAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGuest David Sinclair · Host Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:31:30ENLex Fridman· May 24, 2021Podcast · 2 speakersThe Brain Is the Last Unengineered System in SocietyGuest Bryan Johnson · Host Lex FridmanBryan Johnson demos Kernel Flow on Lex Fridman, then argues that cognition is society's largest unmeasured input and that numbers, not vibes, should run mental health, diet, and the next wave of brain interfaces.
2:39:45ENLex Fridman· Oct 25, 2020Podcast · 2 speakersThe obesity gene was never the obesity geneGuest Manolis Kellis · Host Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
1:02:14ENLex Fridman· Jun 30, 2020Podcast · 2 speakersThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsGuest Robert Langer · Host Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:12:03ENLex Fridman· May 5, 2020Podcast · 2 speakersMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishGuest Daphne Koller · Host Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
36:10ENLex Fridman· Nov 12, 2019Podcast · 2 speakersSo You're Saying There's a Chance: Musk on Neuralink, AI, and a Pale Blue DotGuest Elon Musk · Host Lex FridmanLex Fridman and Elon Musk move from consciousness and an AI referee to the engineering of a brain implant, Tesla Autopilot, and Carl Sagan's lonely speck.
1:17:29ENLex Fridman· Sep 23, 2019Podcast · 2 speakersThe Algorithm Is Already Better. The Clinic Still Uses 1967.Guest Regina Barzilay · Host Lex FridmanMIT's Regina Barzilay on why deep learning already beats the breast-cancer 'density' score — and why data, liability, and incentives still will not move.
1:00:11ENLex Fridman· Jun 17, 2019Podcast · 2 speakersRosalind Picard: Clippy Never Saw You Frown, and That's the Whole ProblemGuest Rosalind Picard · Host Lex FridmanThe MIT professor who named affective computing on emotion recognition, privacy, seizure-detecting wearables, and why a device you can take off is safer than a camera you cannot see.
33:07ENLex Fridman· Dec 4, 2018Podcast · 2 speakersThey Ran an Extension Cord Next Door and Invented GoogleGuest Eric Schmidt · Host Lex FridmanEric Schmidt tells Lex Fridman that Larry and Sergey never held the entrepreneurship meeting: they had a better algorithm, too little power in the dorm, and a $100,000 check.
1:02:57ENCognitive Revolution "How AI Changes Everything"PodcastVirtual Biopsies in One Second: How a Seven-Year-Old CycleGAN Is Beating Newer Models in the ClinicHost Nathan LabenzTanishq Mathew Abraham explains how deep learning turns label-free 3D tissue images into virtual H&E stains fast enough to guide tumor surgery.
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Unsupervised Learning: With Jacob EffronPodcastOscar Health's AI Playbook: Translate the Bureaucracy First, Then Reinvent CareHost Jacob EffronMario, Oscar Health's CTO and co-founder, explains how a regulated insurer deploys LLMs today and what stands between healthcare and AI doctors.
2:04:21ENCognitive Revolution "How AI Changes Everything"Podcast"AI Doctors Are Here": A Father's Account of Fighting His Son's Burkitt Leukemia With GPT-5 Pro and Gemini 3Host Nathan LabenzNathan Labenz recounts the first three weeks of his 6-year-old son's cancer diagnosis and how frontier models served as second opinions, bedside co-pilots and relapse planners.
1:22:17ENCognitive Revolution "How AI Changes Everything"PodcastOne Set of Weights, Fourteen Medical Tasks: Inside Google's Multimodal Med-PaLM MHost Nathan LabenzVivek Natarajan and Tao Tu explain how Google built a single generalist biomedical model that reads images, genomics and text, and what it will take to put it in front of patients.