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1:28:43ENClinical Guidelines Are 11% Evidence. Curai’s Founder Still Wants GPT-4 in the Exam RoomHost Nathan LabenzNeal Khosla of Curai Health argues that large language models already match median U.S. physicians on today’s tests — and that the real work is scaffolding, supervision, and a doctor’s signature.
11:07ENTesting MosaicML MPT-7B Chat and StoryWriter in 2023Matthew Berman · Forward FutureMatthew Berman examines MPT-7B model variants, their licenses and a mixed set of local tests.
5:11ENInstalling PrivateGPT to Ask Questions About Local Documents: A 2023 WalkthroughMatthew Berman · Forward FutureMatthew Berman demonstrates the original PrivateGPT setup, from cloning the repository and downloading models to ingesting files and querying them locally.
1:06:02ENYann LeCun on Open AI Models, Safety and the Future of ResearchGuest Yann Lecun · Host Harry StebbingsMeta’s chief AI scientist discusses language models, research priorities and his contested views on AI risk and employment.
1:51:12ENHarvey Silverglate Would Fire 95 Percent of Harvard's AdministratorsGuest Harvey Silverglate · Host Lex FridmanThe FIRE co-founder, running as a write-in for Harvard's Board of Overseers, tells Lex Fridman why hate speech is more useful than love speech and why discomfort is the price of a free campus.
58:47ENClem Delangue on Open AI, Model Choices and Building Hugging FaceGuest Clem Delangue · Host Harry StebbingsThe Hugging Face CEO discusses the company’s pivot, open-model economics, legal uncertainty and his approach to fundraising.
5:24ENGoogle I/O 2023: Bard, PaLM 2 and AI Across Google's ProductsMatthew Berman · Forward FutureMatthew Berman reviews Google's 2023 AI announcements and weighs its focus on improving established products.
58:24ENAmong 100 Random Doctors, Zak Kohane Would Be Surprised If One Beat GPT-4Host Nathan LabenzHarvard's biomedical informatics chair on a rare newborn case, why drug-style trials will not certify a general medical model, and why the AI should still work for the patient.
51:55ENNine orders of magnitude later, he shipped a companion, not an oracleHost Sarah Guo, Elad GilDeepMind co-founder Mustafa Suleyman tells No Priors why Inflection’s first product is a personal AI that sits in your corner, and why the missing piece is a router, not a bigger model.
11:39ENA 2023 Look at ChatGPT Plugins, Browsing and Code InterpreterMatthew Berman · Forward FutureMatthew Berman tests early ChatGPT integrations for travel, groceries, web browsing and Python analysis. The demonstrations show both useful outputs and errors in a historical interface.
2:28ENVince Hankes on Thrive Capital’s OpenAI Investment DecisionGuest Vince Hankes · Host Harry StebbingsIn a 2023 interview excerpt, Hankes explains how his firm weighed a high price against uncertain adoption and potential upside.
4:24ENLars on Trading and Learning at Jane StreetLars · Jane StreetA London trader describes the mix of research, monitoring and coding, and what new hires learn on the job.
1:10:50ENSix Sales Leaders on Building Careers and Raising FamiliesGuest Jessica Arnold, Lauren Schwartz, Stevie Case, Renu Gupta, Maggie Hott, Julie Maresca · Host Harry StebbingsA 20Sales panel discusses boundaries, parental leave, supportive managers and the realities of working motherhood.
5:06ENJack on Hospitality and Office Life at Jane StreetJack · Jane StreetA London hospitality team member describes the work behind reception, travel and food service, and the culture he experiences at the office.
3:48ENVal on Software Engineering and Collaboration at Jane StreetVal · Jane StreetA London developer explains how colleagues teach new hires, review production code, and work across teams.
3:03ENRajan on IT, Collaboration and Learning at Jane StreetRajan · Jane StreetRajan describes the IT team's role supporting critical systems and the problem-solving skills he brought from studying chemistry.
5:56ENLiora on Production Engineering at Jane StreetLiora Friedberg · Jane StreetA London production engineer describes incident response, project work, communication, and mentorship across the firm.
3:44ENAlistair on Trading and Learning at Jane StreetAlistair · Jane StreetA London trader describes the skills, training, and daily routines behind his work at Jane Street.
26:18ENAvlok Kohli on Startup Funding, Fund Liquidity and AngelList’s AI WorkflowsGuest Avlok Kohli · Host Harry StebbingsA 2023 conversation about venture financing conditions, secondary fund positions and automating parts of fund administration.
4:14:33ENThe Next Token Is Not a Proof: Stephen Wolfram on ChatGPT and Computational TruthGuest Stephen Wolfram · Host Lex FridmanIn his fourth conversation with Lex Fridman, Stephen Wolfram contrasts large language models with Wolfram|Alpha, then follows computational irreducibility from ChatGPT through observers, thermodynamics, and the three great theories of twentieth-century physics.
1:01:17ENThe $300 million Gates refused, and the $10 billion that went to OpenAIHost Nathan LabenzRobert Scoble and Ben Tossell talk with Nathan Labenz about AI scouting, Apple's still-sleeping neural engines, and whether incumbents or AI-first startups will win.
1:47:37ENChris Paik on Venture Incentives, Consumer Platforms and Market TimingGuest Chris Paik · Host Harry StebbingsThe Pace Capital partner discusses equal partnerships, creator economics, the limits of venture financing and conflicts between investors and founders.
14:29ENA 2023 Google Memo on Open Models, LoRA and AI’s Competitive MoatMatthew Berman · Forward FutureMatthew Berman reviews a leaked employee essay arguing that rapid community iteration could challenge proprietary AI labs, and traces the early LLaMA ecosystem.
3:31:03ENAsk for the Definition First: David Pakman on Labels, Trump, and a Tweet He Should Have Left UpGuest David Pakman · Host Lex FridmanThe progressive host sits with Lex Fridman for a long walk through political words, Trump versus Biden, January 6th, and why most of his own show sits at the top of the information food pyramid.
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