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1:26:53EN
Lex Fridman· Nov 5, 2021Podcast · 2 speakersFrancis Collins Cannot Exclude a Lab LeakGuest Francis Collins · Host Lex FridmanThe outgoing NIH director talks with Lex Fridman about COVID origins, gain-of-function research, Anthony Fauci, vaccines, and why scientific certainty is the wrong pose.
2:59:12ENLex Fridman· Jun 20, 2021Podcast · 2 speakersNature Never Dealt This CardGuest Rob Reid · Host Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
1:41:34ENLex Fridman· Jun 6, 2021Podcast · 2 speakersAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGuest David Sinclair · Host Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:17:42ENLex Fridman· Jan 11, 2021Podcast · 2 speakersThe building block of life is a bead on a string, not the whole proteinGuest Dmitry Korkin · Host Lex FridmanDmitry Korkin tells Lex Fridman why protein domains, a triangular spike, and a conservative viral shell matter more than the AlphaFold headline, and why a Nobel laureate once answered a midnight forum post.
2:14:55ENLex Fridman· Nov 30, 2020Podcast · 2 speakersHis Wife Calls Him the RadioGuest Manolis Kellis · Host Lex FridmanMIT computational biologist Manolis Kellis spends the first forty minutes of his fourth Lex Fridman conversation on the songs that formed him, then turns to 42, dinosaurs, and why hunting for meaning matters more than finding it.
2:39:45ENLex Fridman· Oct 25, 2020Podcast · 2 speakersThe obesity gene was never the obesity geneGuest Manolis Kellis · Host Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
2:10:53ENLex Fridman· Sep 12, 2020Podcast · 2 speakersAll Your DNA Would Reach Jupiter a Hundred Times OverGuest Manolis Kellis · Host Lex FridmanManolis Kellis talks Lex Fridman through the epigenome, Neanderthals, Europa, midlife, and why "are you happy?" is the wrong question.
2:29:24ENLex Fridman· Jul 31, 2020Podcast · 2 speakersWe Are the Descendants of the First Digital ComputerGuest Manolis Kellis · Host Lex FridmanMIT computational biologist Manolis Kellis tells Lex Fridman why life is digital, why any two humans are 99.9 percent identical, and what evolutionary signatures reveal inside SARS-CoV-2.
1:02:14ENLex Fridman· Jun 30, 2020Podcast · 2 speakersThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsGuest Robert Langer · Host Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:12:03ENLex Fridman· May 5, 2020Podcast · 2 speakersMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishGuest Daphne Koller · Host Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
2:09:02ENLex Fridman· Apr 22, 2020Podcast · 2 speakersA Hundred-Nanometer Machine That Is Not Quite AliveGuest Dmitry Korkin · Host Lex FridmanDmitry Korkin walks through the structural genomics of SARS-CoV-2, from spike-ACE2 docking to drug-binding sites, vaccines, and cruise-ship simulations, recorded in the first spring of the pandemic.
58:03EN
Jane Street· Feb 18, 2020Matt Might on an Algorithm for Precision MedicineMatt Might · University of Alabama at BirminghamA computer scientist describes how genetic data, experimental models and logic programming can help clinicians investigate difficult cases.
57:42ENLex Fridman· Aug 12, 2019Podcast · 2 speakersA Brain Organoid Is Not a BrainGuest Paola Arlotta · Host Lex FridmanHarvard developmental biologist Paola Arlotta on how the cerebral cortex is built, why timing and mechanical force are part of the code, and why a dish of stem cells is only a window onto that process.
56:20EN
No Priors: AI, Machine Learning, Tech, & StartupsPodcast · 2 speakersBiohub's Bet: Building Open AI World Models of Biology From Proteins Up to CellsHost Sarah Guo, Elad GilMark Zuckerberg, Priscilla Chan and Alex Rives explain why Biohub pairs a frontier AI lab with frontier wet-lab biology, and why it releases tools like ESMFold2 as open source.
11:51ENLex FridmanPodcastBuilding a Brain: Paola Arlotta on the Choreography of Human Brain DevelopmentHost Lex FridmanA Harvard stem cell biologist walks through how the embryo builds the cerebral cortex, why order and environment matter, and why development continues into our twenties.
1:03:59EN
Cognitive Revolution "How AI Changes Everything"PodcastBuilding a World Model of Life: Biohub's Alex Rives on Why Better Measurement Must Come Before Virtual CellsHost Nathan LabenzBiohub's head of science explains why today's virtual cell models fall short, how a $1.8 billion data push aims to fix it, and what a five-year information-level model of the cell could unlock.
1:45:55ENCognitive Revolution "How AI Changes Everything"PodcastFrom Static Structures to Moving Molecules: Where AI for Protein Design Stands After AlphaFold 3Host Nathan LabenzComputational biochemist Amelie Schreiber walks Nathan Labenz through six months of progress in structure prediction, molecular dynamics, peptide and antibody models, and early agent-driven design workflows.