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2:49:41ENNazi Science Was Not Anti-Science. It Was Science with a Purity QuestGuest Robert Proctor · Host Lex FridmanStanford historian Robert Proctor on how ideology, tobacco, and the taxonomic impulse turn scientists into widget-builders.
51:15ENAgility at Scale: Alignment, Autonomy and Two MindsetsDaniel Terhorst-North, Anna UrbaniakDaniel Terhorst-North and Anna Urbaniak discuss coordination and learning in large organizations.
45:59ENSahil Bloom on Building an Audience and Starting a Venture FundGuest Sahil Bloom · Host Harry StebbingsThe writer and investor discusses consistent content, media-led investing, luck and a changing definition of hard work.
2:00:13ENHalf of America Dislikes Him. Zuckerberg Still Wants Presence, Not ScreensGuest Mark Zuckerberg · Host Lex FridmanLex Fridman sits with Meta CEO Mark Zuckerberg on virtual presence, Instagram's teen research, free speech, and why every content decision costs the company half the country.
30:43ENJohn Doerr on Climate Investing, Google and a Plan for Net ZeroGuest John Doerr · Host Harry StebbingsThe Kleiner Perkins investor discusses timing, portfolio risk and the measurable climate goals in Speed & Scale.
2:01:35ENA no-click iPhone exploit sold for $2.5 million. Silence was the only condition.Guest Nicole Perlroth · Host Lex FridmanNicole Perlroth tells Lex Fridman how zero-days, ransomware, and a privately owned power grid turned curiosity into everyday cyberwar.
2:10:29ENDevon Larratt’s Only Priority Is Winning. Everything Else Is a ToolGuest Devon Larratt · Host Lex FridmanLex Fridman sits with one of the greatest arm wrestlers of all time to talk John Brzenk, Levan Saginashvili, Russian volume, a weaponized voice, and why everybody is beatable.
2:37:03ENNo One Knows How to Make a PencilGuest Tim Urban · Host Lex FridmanWait But Why's Tim Urban spent five years on a book about why society is tearing itself apart, then sat down with Lex Fridman to talk aliens, Musk, Neuralink, and the war inside a procrastinator's head.
2:17:29ENThe knowledge doctors trust is built to sell drugsGuest John Abramson · Host Lex FridmanHarvard physician John Abramson tells Lex Fridman how pharmaceutical companies captured medical knowledge, and why American healthcare spends more while delivering less.
30:53ENMark Cuban on Cost Plus Drugs, Hiring and Healthcare PricingGuest Mark Cuban · Host Harry StebbingsIn a 2022 interview, Cuban describes the pharmacy’s early pricing model, his self-funded venture and his views on the US healthcare system.
1:42:58ENDon't Talk Conclusions. Talk Data.Guest Garry Nolan · Host Lex FridmanA Stanford immunologist sat through the brain scans of people who said they had met UFOs—and treats the rest of the subject the same way.
42:35ENMac Conwell on Building RareBreed and Supporting Overlooked FoundersGuest McKeever Conwell II · Host Harry StebbingsThe investor describes his path into venture, fundraising through relationships on Twitter and his proposed changes to the industry.
2:46:31ENThe Official Scientific Worldview Is Incompatible With ConsciousnessGuest Philip Goff · Host Lex FridmanDurham philosopher Philip Goff tells Lex Fridman why panpsychism — the view that consciousness is fundamental and ubiquitous — is the least-bad theory of mind.
2:59:02ENWhen the Answers Are Already Known, Look Where Everyone Stopped LookingHost Lex FridmanGeorges St-Pierre, John Danaher, and Gordon Ryan sit with Lex Fridman to unpack success, confidence, training, and why the greatest of all time may not even be born yet.
2:16:40ENEach Blockbuster Is a Startup. The Chocolate River Kills It.Guest Thomas Tull · Host Lex FridmanThomas Tull tells Lex Fridman how a novice raised institutional capital for Hollywood, then applied the same judgment to AI, mammoths, the Steelers, and a Rolling Stones tour.
45:16ENFrank Slootman on Focus, Performance and Leading a BoardGuest Frank Slootman · Host Harry StebbingsSnowflake’s then-CEO discusses diagnosing problems, creating urgency, evaluating performance and giving capable teams room to act.
2:45:10ENA Teenager Learns to Drive in Twenty Hours. A Car Still Cannot.Guest Yann Lecun · Host Lex FridmanYann LeCun tells Lex Fridman why self-supervised world models are the missing dark matter of intelligence, and why machines are not even at the level of a house cat.
1:24:16ENChris Sacca on Venture Investing, Climate and the Responsibilities of WealthGuest Chris Sacca · Host Harry StebbingsThe investor reflects on early losses, founder relationships and Lowercarbon’s climate thesis, and explains his criticism of Facebook and SoftBank.
3:59:41ENDust Covered the Origin of the UniverseGuest Brian Keating · Host Lex FridmanExperimental cosmologist Brian Keating on telescopes as time machines, the BICEP2 false alarm, and what it actually means to lose a Nobel Prize.
2:58:05ENThe Declaration of 1776 and the Constitution of 1787 Pull in Opposite DirectionsHost Lex FridmanYaron Brook and Yoram Hazony spend three hours arguing whether a free society is built on the individual or on the sticky, hierarchical groups that individuals cannot live without.
1:50:07ENBombing Is Data: Mark Normand on Love, Comedy, and Eating Shit EarlyGuest Mark Normand · Host Lex FridmanStand-up comedian Mark Normand talks with Lex Fridman about keeping love in shape, growing up the odd kid in New Orleans, why open-mic hell is comedy’s first level, and when a joke is finally done.
1:22:34ENStephen Dolan on Memory Management, Garbage Collection, and OCamlYaron Minsky, Stephen Dolan · Jane StreetFrom tracing and reference counting to prefetching, local allocation and unboxed types, Dolan explains the tradeoffs behind safe, efficient memory management.
2:21:49ENFocused Protection, Not Lockdowns: Jay Bhattacharya on What Public Health Got WrongGuest Jay Bhattacharya · Host Lex FridmanThe Stanford physician and co-author of the Great Barrington Declaration tells Lex Fridman why age-stratified risk, seroprevalence data, and the ignored costs of isolation pointed to a different COVID strategy.
3:23:42ENBeauty will save the world — Michael Malice's New Year's case for hopeGuest Michael Malice · Host Lex FridmanOn New Year's Eve 2021, Lex Fridman and Michael Malice talk through Dostoevsky, evil, Austin, anarchism, and why a cheap GoBot on a Brooklyn shelf still counts as proof.
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