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2:37:03ENNo One Knows How to Make a PencilGuest Tim Urban · Host Lex FridmanWait But Why's Tim Urban spent five years on a book about why society is tearing itself apart, then sat down with Lex Fridman to talk aliens, Musk, Neuralink, and the war inside a procrastinator's head.
2:17:29ENThe knowledge doctors trust is built to sell drugsGuest John Abramson · Host Lex FridmanHarvard physician John Abramson tells Lex Fridman how pharmaceutical companies captured medical knowledge, and why American healthcare spends more while delivering less.
30:53ENMark Cuban on Cost Plus Drugs, Hiring and Healthcare PricingGuest Mark Cuban · Host Harry StebbingsIn a 2022 interview, Cuban describes the pharmacy’s early pricing model, his self-funded venture and his views on the US healthcare system.
1:42:58ENDon't Talk Conclusions. Talk Data.Guest Garry Nolan · Host Lex FridmanA Stanford immunologist sat through the brain scans of people who said they had met UFOs—and treats the rest of the subject the same way.
42:35ENMac Conwell on Building RareBreed and Supporting Overlooked FoundersGuest McKeever Conwell II · Host Harry StebbingsThe investor describes his path into venture, fundraising through relationships on Twitter and his proposed changes to the industry.
2:46:31ENThe Official Scientific Worldview Is Incompatible With ConsciousnessGuest Philip Goff · Host Lex FridmanDurham philosopher Philip Goff tells Lex Fridman why panpsychism — the view that consciousness is fundamental and ubiquitous — is the least-bad theory of mind.
2:59:02ENWhen the Answers Are Already Known, Look Where Everyone Stopped LookingHost Lex FridmanGeorges St-Pierre, John Danaher, and Gordon Ryan sit with Lex Fridman to unpack success, confidence, training, and why the greatest of all time may not even be born yet.
2:16:40ENEach Blockbuster Is a Startup. The Chocolate River Kills It.Guest Thomas Tull · Host Lex FridmanThomas Tull tells Lex Fridman how a novice raised institutional capital for Hollywood, then applied the same judgment to AI, mammoths, the Steelers, and a Rolling Stones tour.
45:16ENFrank Slootman on Focus, Performance and Leading a BoardGuest Frank Slootman · Host Harry StebbingsSnowflake’s then-CEO discusses diagnosing problems, creating urgency, evaluating performance and giving capable teams room to act.
2:45:10ENA Teenager Learns to Drive in Twenty Hours. A Car Still Cannot.Guest Yann Lecun · Host Lex FridmanYann LeCun tells Lex Fridman why self-supervised world models are the missing dark matter of intelligence, and why machines are not even at the level of a house cat.
1:24:16ENChris Sacca on Venture Investing, Climate and the Responsibilities of WealthGuest Chris Sacca · Host Harry StebbingsThe investor reflects on early losses, founder relationships and Lowercarbon’s climate thesis, and explains his criticism of Facebook and SoftBank.
3:59:41ENDust Covered the Origin of the UniverseGuest Brian Keating · Host Lex FridmanExperimental cosmologist Brian Keating on telescopes as time machines, the BICEP2 false alarm, and what it actually means to lose a Nobel Prize.
2:58:05ENThe Declaration of 1776 and the Constitution of 1787 Pull in Opposite DirectionsHost Lex FridmanYaron Brook and Yoram Hazony spend three hours arguing whether a free society is built on the individual or on the sticky, hierarchical groups that individuals cannot live without.
1:50:07ENBombing Is Data: Mark Normand on Love, Comedy, and Eating Shit EarlyGuest Mark Normand · Host Lex FridmanStand-up comedian Mark Normand talks with Lex Fridman about keeping love in shape, growing up the odd kid in New Orleans, why open-mic hell is comedy’s first level, and when a joke is finally done.
1:22:34ENStephen Dolan on Memory Management, Garbage Collection, and OCamlYaron Minsky, Stephen Dolan · Jane StreetFrom tracing and reference counting to prefetching, local allocation and unboxed types, Dolan explains the tradeoffs behind safe, efficient memory management.
2:21:49ENFocused Protection, Not Lockdowns: Jay Bhattacharya on What Public Health Got WrongGuest Jay Bhattacharya · Host Lex FridmanThe Stanford physician and co-author of the Great Barrington Declaration tells Lex Fridman why age-stratified risk, seroprevalence data, and the ignored costs of isolation pointed to a different COVID strategy.
3:23:42ENBeauty will save the world — Michael Malice's New Year's case for hopeGuest Michael Malice · Host Lex FridmanOn New Year's Eve 2021, Lex Fridman and Michael Malice talk through Dostoevsky, evil, Austin, anarchism, and why a cheap GoBot on a Brooklyn shelf still counts as proof.
2:31:48ENA Car That Cannot Drive Itself Will Be About as Useful as a HorseGuest Elon Musk · Host Lex FridmanIn a Lex Fridman conversation built around Tesla Autopilot, Elon Musk argues that every driver input is an error, that today’s hardware is already enough for full self-driving, and that watching the human will soon matter less than making the system safer than a person.
1:32:38ENRay Dalio’s Big Cycle: Empires Fall When They Get Rich, Indebted, and at War With ThemselvesGuest Ray Dalio · Host Lex FridmanLex Fridman talks with Bridgewater founder Ray Dalio about the 500-year rise and fall of reserve-currency empires, the U.S.–China contest, and the personal recipes that outlast any cycle.
2:46:40ENThe Tools That Fit in a Head Were Built by People Who Fit in a VanGuest Peter Wang · Host Lex FridmanAnaconda's Peter Wang talks with Lex Fridman about Python, cybernetic systems, and why sharing software creates value that scarcity economics still cannot price.
1:08:04ENBreakthroughs Run on Speed. Trust Runs on Patience.Guest Albert Bourla · Host Lex FridmanPfizer CEO Albert Bourla talks with Lex Fridman about the November 2020 unblinding, a $2.3 billion all-in bet, and why a historic vaccine still divided the public.
2:18:40ENIt Was Not a Slippery Slope. It Was a Leap.Guest Norman Naimark · Host Lex FridmanStanford historian Norman Naimark on Stalin, Mao, the Holodomor, and why the flame of human kindness is so easy to put out.
4:55:09ENJamie Metzl Puts the Lab-Leak Odds at 85 PercentGuest Jamie Metzl · Host Lex FridmanThe genetic-engineering author walks Lex Fridman through the circumstantial case for a Wuhan accident, the cover-up he says is no longer debatable, and why the next pandemic will be decided by transparency, not blame.
2:15:56ENA Theory That Fits Anything Is Not Even WrongGuest Peter Woit · Host Lex FridmanColumbia physicist Peter Woit tells Lex Fridman why string theory's original idea emptied out, why four dimensions are enough, and what twistor theory still offers.
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