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2:21:49ENFocused Protection, Not Lockdowns: Jay Bhattacharya on What Public Health Got WrongGuest Jay Bhattacharya · Host Lex FridmanThe Stanford physician and co-author of the Great Barrington Declaration tells Lex Fridman why age-stratified risk, seroprevalence data, and the ignored costs of isolation pointed to a different COVID strategy.
3:23:42ENBeauty will save the world — Michael Malice's New Year's case for hopeGuest Michael Malice · Host Lex FridmanOn New Year's Eve 2021, Lex Fridman and Michael Malice talk through Dostoevsky, evil, Austin, anarchism, and why a cheap GoBot on a Brooklyn shelf still counts as proof.
2:31:48ENA Car That Cannot Drive Itself Will Be About as Useful as a HorseGuest Elon Musk · Host Lex FridmanIn a Lex Fridman conversation built around Tesla Autopilot, Elon Musk argues that every driver input is an error, that today’s hardware is already enough for full self-driving, and that watching the human will soon matter less than making the system safer than a person.
1:32:38ENRay Dalio’s Big Cycle: Empires Fall When They Get Rich, Indebted, and at War With ThemselvesGuest Ray Dalio · Host Lex FridmanLex Fridman talks with Bridgewater founder Ray Dalio about the 500-year rise and fall of reserve-currency empires, the U.S.–China contest, and the personal recipes that outlast any cycle.
2:46:40ENThe Tools That Fit in a Head Were Built by People Who Fit in a VanGuest Peter Wang · Host Lex FridmanAnaconda's Peter Wang talks with Lex Fridman about Python, cybernetic systems, and why sharing software creates value that scarcity economics still cannot price.
1:08:04ENBreakthroughs Run on Speed. Trust Runs on Patience.Guest Albert Bourla · Host Lex FridmanPfizer CEO Albert Bourla talks with Lex Fridman about the November 2020 unblinding, a $2.3 billion all-in bet, and why a historic vaccine still divided the public.
2:18:40ENIt Was Not a Slippery Slope. It Was a Leap.Guest Norman Naimark · Host Lex FridmanStanford historian Norman Naimark on Stalin, Mao, the Holodomor, and why the flame of human kindness is so easy to put out.
4:55:09ENJamie Metzl Puts the Lab-Leak Odds at 85 PercentGuest Jamie Metzl · Host Lex FridmanThe genetic-engineering author walks Lex Fridman through the circumstantial case for a Wuhan accident, the cover-up he says is no longer debatable, and why the next pandemic will be decided by transparency, not blame.
2:15:56ENA Theory That Fits Anything Is Not Even WrongGuest Peter Woit · Host Lex FridmanColumbia physicist Peter Woit tells Lex Fridman why string theory's original idea emptied out, why four dimensions are enough, and what twistor theory still offers.
55:02ENThe Day After Olympic Gold, Tom Brands Mowed the LawnGuest Tom Brands · Host Lex FridmanIowa's head wrestling coach tells Lex Fridman why hatred of losing, extra rope climbs, and a lockstep staff built both a champion and a program.
2:42:47ENThe Invasion Was a MistakeGuest Robert Crews · Host Lex FridmanStanford historian Robert Crews on why Afghanistan was never the center of 9/11, what Bin Laden actually wrote, and how four presidents stayed on the highway until the tank ran dry.
2:44:38ENPosting a photo of this moment was not a product category yetGuest Kevin Systrom · Host Lex FridmanKevin Systrom tells Lex Fridman how Instagram began as a failed check-in app, hid a slow upload behind a caption screen, and later sold a thirteen-person company to Facebook for a billion dollars.
2:15:27ENHe Took People Down in 53 of 55 MMA Rounds. Then Two Clips Defined Him.Guest Ben Askren · Host Lex FridmanBen Askren talks with Lex Fridman about scoring fights, chasing hard matches, building a wrestling robot, and why he says he never proved he was the best.
3:14:14ENFour Joints, Eighty Thousand Pounds: Boris Sofman on Cozmo and WaymoGuest Boris Sofman · Host Lex FridmanAnki's co-founder on saturating a few channels of expression, why a beloved robot company still died, and how the same constraint mindset now runs Waymo's trucks.
2:39:51ENChemical Rockets Are an Accident of HistoryGuest Neal Stephenson · Host Lex FridmanNeal Stephenson talks with Lex Fridman about WWII’s leftover launchers, why the stars need a religion, AR baby goats, and why fun is a better goal than greatness.
2:41:13ENThe Minefield Used to Be the Point: Niall Ferguson on Universities, Money, and 1914Guest Niall Ferguson · Host Lex FridmanThe historian tells Lex Fridman why he is founding a university in Austin, why money is a technology of trust, and which cabinet decision turned a European war into the twentieth century.
1:26:53ENFrancis Collins Cannot Exclude a Lab LeakGuest Francis Collins · Host Lex FridmanThe outgoing NIH director talks with Lex Fridman about COVID origins, gain-of-function research, Anthony Fauci, vaccines, and why scientific certainty is the wrong pose.
3:12:17ENYou Better Already Have Everything You Ever WantedGuest Steve Viscelli · Host Lex FridmanA former long-haul driver turned Penn sociologist walks Lex Fridman through how trucking fell from a golden-age trade to a last-resort job, and the six ways robots might finish the work.
1:01:11ENAnil Madhavapeddy on MirageOS and the Evolution of Operating SystemsYaron Minsky, Anil Madhavapeddy · Jane StreetFrom Xen and unikernels to OCaml's multicore research, a systems researcher explains how changing abstractions reshape infrastructure.
2:23:08ENHate Losing More Than You Love Winning: Jimmy Pedro on Forging Judo ChampionsGuest Jimmy Pedro · Host Lex FridmanThe four-time Olympian and coach of Kayla Harrison and Travis Stevens on uchi mata, visualization, and why American judo loses its teenagers at thirteen.
1:46:47ENA Perfect Rapid Test Would Fail the FDA. Michael Mina Explains Why That Is the PointGuest Michael Mina · Host Lex FridmanThe Harvard immunologist tells Lex Fridman that paper-strip antigen tests answer the only public-health question that matters—are you infectious right now—and that one presidential sentence could unlock them.
3:38:43ENConsciousness Is a Step Down From IntelligenceGuest Stephen Wolfram · Host Lex FridmanStephen Wolfram tells Lex Fridman how simple programs, a discrete fabric of space, and a computationally bounded observer together explain complexity, physics, and why the universe exists.
12:40ENThe 2021 Summer of Math Exposition: Selected Works and Lessons3Blue1Brown highlights mathematical explainers, from light in a mug to Bézier curves and Pick’s theorem.
1:11:03ENCarl Hart’s case that addiction lives outside the moleculeGuest Carl Hart · Host Lex FridmanThe Columbia psychologist tells Lex Fridman that most drug effects are positive, that alcohol withdrawal is deadlier than heroin’s, and that the war on drugs pays a long list of people to keep a scapegoat in place.
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