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4:06:06ENShe Picked Up a Perfectly Laced Boot and Said They Could Reuse ItGuest Kelsi Sheren · Host Lex FridmanKelsi Sheren was a 19-year-old, 103-pound Canadian artillery gunner on an M777 howitzer in Afghanistan; she came home with the light switch off and spent a decade finding a way back.
2:44:08ENForty Feet Behind: A New York Firefighter's 9/11Guest Niels Jorgensen · Host Lex FridmanNiels Jorgensen, an FDNY veteran at Ground Zero on September 11, 2001, tells Lex Fridman who did not come home, what the dust did to the living, and why September 12 still matters.
3:28:40ENThere Are More Viruses in a Liter of Seawater Than People on EarthGuest Vincent Racaniello · Host Lex FridmanColumbia virologist Vincent Racaniello talks Lex Fridman through ocean-scale particle counts, mRNA vaccines, and why speaking with false certainty does more damage than a virus.
2:48:18ENHumans are the only species that skip sleep on purposeGuest Matt Walker · Host Lex FridmanBerkeley sleep scientist Matt Walker talks with Lex Fridman about why we sleep, what caffeine and dreams actually do, and whether passion can justify the health cost of staying up.
1:44:54ENIf the meat needs a sauce, start over with the animalGuest Anya Fernald · Host Lex FridmanBelcampo co-founder Anya Fernald tells Lex Fridman why cooking is service, why "grass-fed" is an unregulated word, and why regenerative grazing cannot scale without human attention.
2:36:06ENThe Experience Is Not in the Pill. Rick Doblin Spent Decades Proving the Context Is.Guest Rick Doblin · Host Lex FridmanThe MAPS founder walks Lex Fridman from Huxley's reducing valve to a Phase 3 MDMA trial for PTSD, arguing that legality, safety, and culture matter more than new molecules.
2:09:48ENRoger Reaves Flew Cocaine for Escobar. He Says the Money Was Never Worth ItGuest Roger Reaves · Host Lex FridmanLex Fridman talks with one of history's most prolific drug smugglers about the Medellín Cartel, Barry Seal, two shoot-downs, and 33 years in prison.
3:17:09ENWhat Science Is Left When Institutions Decide What Cannot Be SaidGuest Bret Weinstein · Host Lex FridmanEvolutionary biologist Bret Weinstein talks with Lex Fridman about lab-leak evidence, ivermectin, captured public-health agencies, and why the 1% at the fringe is the key to progress.
2:59:12ENNature Never Dealt This CardGuest Rob Reid · Host Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
1:41:34ENAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGuest David Sinclair · Host Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:20:15ENThe virus is not meters away. It is hops away.Guest Po-Shen Loh · Host Lex FridmanPo-Shen Loh talks with Lex Fridman about teaching invention, combinatorics, and a contact-tracing app that warns you before you get sick.
2:17:42ENThe building block of life is a bead on a string, not the whole proteinGuest Dmitry Korkin · Host Lex FridmanDmitry Korkin tells Lex Fridman why protein domains, a triangular spike, and a conservative viral shell matter more than the AlphaFold headline, and why a Nobel laureate once answered a midnight forum post.
2:18:26ENThe Dollar Paper Strip That Could Have Turned Covid's CurveGuest Michael Mina · Host Lex FridmanHarvard immunologist Michael Mina tells Lex Fridman why twice-weekly antigen tests could have reversed the pandemic—and why regulation, not manufacturing, blocked them.
3:39:01ENMatthew Johnson on loosening the priors that run a human lifeGuest Matthew Johnson · Host Lex FridmanThe Johns Hopkins psychiatrist walks Lex Fridman through receptors, addiction, DMT entities, a 15-person smoking trial, and why psychedelics have taught us almost nothing about the hard problem of consciousness.
2:39:45ENThe obesity gene was never the obesity geneGuest Manolis Kellis · Host Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
2:29:24ENWe Are the Descendants of the First Digital ComputerGuest Manolis Kellis · Host Lex FridmanMIT computational biologist Manolis Kellis tells Lex Fridman why life is digital, why any two humans are 99.9 percent identical, and what evolutionary signatures reveal inside SARS-CoV-2.
2:09:02ENA Hundred-Nanometer Machine That Is Not Quite AliveGuest Dmitry Korkin · Host Lex FridmanDmitry Korkin walks through the structural genomics of SARS-CoV-2, from spike-ACE2 docking to drug-binding sites, vaccines, and cruise-ship simulations, recorded in the first spring of the pandemic.
2:46:36ENThe Great Nap Is OverGuest Eric Weinstein · Host Lex FridmanMathematician Eric Weinstein tells Lex Fridman that seventy-five quiet years selected the wrong leaders, then walks through Geometric Unity, the theory he kept in a drawer for decades.
29:54ENSeven Levels of a Pandemic: Pain, Challenge and Hope From Biology to PhilosophyHost Lex FridmanLex Fridman maps the coronavirus onto seven levels of attack on society and proposes a response and a reason for hope at each one.









