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3:28:40ENThere Are More Viruses in a Liter of Seawater Than People on EarthGuest Vincent Racaniello · Host Lex FridmanColumbia virologist Vincent Racaniello talks Lex Fridman through ocean-scale particle counts, mRNA vaccines, and why speaking with false certainty does more damage than a virus.
2:51:33ENThe Self Is a GPT Prompt: Wojciech Zaremba on Consciousness, Codex, and Fermi's SilenceGuest Wojciech Zaremba · Host Lex FridmanOpenAI co-founder Wojciech Zaremba tells Lex Fridman he thinks we might be alone in the universe — and that GPT-3, Codex, and a one-handed robot already hint at how intelligence is built.
1:36:06ENAfghanistan, Gig Work and Robots: An All-In Debate From 2021Host Jason Calacanis, Chamath Palihapitiya, David Sacks, David FriedbergThe hosts debate the US withdrawal, Chinese technology policy, California gig work and early robotics plans in their August 2021 context.
1:52:17ENOld Theories Rarely Die of Contradiction. They Stop Making New Things.Guest Jed Buchwald · Host Lex FridmanCaltech historian Jed Buchwald talks with Lex Fridman about Kuhn, Newton, and why scientific change is a victory of productivity more than of proof.
2:22:55ENLIGO measures a thousandth of a proton — then a thousand physicists stayed quiet for a monthGuest Barry Barish · Host Lex FridmanNobel laureate Barry Barish tells Lex Fridman how gravitational waves were predicted, doubted, and finally heard with the most precise machine ever built.
3:12:21ENThe Ape's Brain Runs a Dream: Joscha Bach on Consciousness, Freedom, and MeaningGuest Joscha Bach · Host Lex FridmanA long conversation about the self as a control model, the dream world generated by the brain, free will, language models, evil, love, and how to live without a fixed self.
1:52:28ENIf You Die Before You Die: Brian Muraresku's Secret History of PsychedelicsGuest Brian Muraresku · Host Lex FridmanThe author of The Immortality Key tells Lex Fridman why ancient wine was a drug, why Eleusis mattered more than democracy, and why mystics keep running toward death.
2:48:18ENHumans are the only species that skip sleep on purposeGuest Matt Walker · Host Lex FridmanBerkeley sleep scientist Matt Walker talks with Lex Fridman about why we sleep, what caffeine and dreams actually do, and whether passion can justify the health cost of staying up.
2:54:52ENThe Marvelous Proof Still Lives in the MarginHost Lex FridmanLuís and João Batalha, the brothers behind Fermat's Library, talk with Lex Fridman about hidden backstories, a publishing system that buys its own work twice, and how to sit with a paper until it finally clicks.
2:18:29ENYour Cortex Is 150,000 Brains Voting on a Coffee CupGuest Jeff Hawkins · Host Lex FridmanJeff Hawkins tells Lex Fridman that intelligence is learning a model of the world, the neocortex is tens of thousands of independent maps that vote, and the fastest path to machine intelligence is reverse-engineering that sheet.
2:42:57ENThe Thousand-Pound Day Was Easy. The Years Before It Were Not.Guest Chris Duffin · Host Lex FridmanLex Fridman talks with strength athlete and engineer Chris Duffin about squatting and deadlifting 1,000 pounds for reps, stacking the torso like a pressure vessel, and a childhood spent handling live rattlesnakes.
2:30:30ENThe Fallacy of the Successful First StepGuest Ishan Misra · Host Lex FridmanBerkeley's Jitendra Malik explains why computer vision still looks easy, why fully autonomous driving is not near, and what children know that today's networks do not.
3:01:47ENA hundred miles is a lifetime compressed into one dayGuest Zach Bitter · Host Lex FridmanZach Bitter talks with Lex Fridman about the 100-mile mind, quitting, aerobic training, fat-adapted fueling, and a run across America.
2:13:21ENThe Fourth Deduction Often Turns Out to Be the First PrincipleGuest Cumrun Vafa · Host Lex FridmanHarvard string theorist Cumrun Vafa on why physicists distrust deduction, how a graviton fell out of a formula nobody wrote for gravity, and what extra dimensions are actually for.
1:44:54ENIf the meat needs a sauce, start over with the animalGuest Anya Fernald · Host Lex FridmanBelcampo co-founder Anya Fernald tells Lex Fridman why cooking is service, why "grass-fed" is an unregulated word, and why regenerative grazing cannot scale without human attention.
2:36:06ENThe Experience Is Not in the Pill. Rick Doblin Spent Decades Proving the Context Is.Guest Rick Doblin · Host Lex FridmanThe MAPS founder walks Lex Fridman from Huxley's reducing valve to a Phase 3 MDMA trial for PTSD, arguing that legality, safety, and culture matter more than new molecules.
2:39:53ENThere's Something at the Edge of the Solar SystemGuest Konstantin Batygin · Host Lex FridmanCaltech planetary astrophysicist Konstantin Batygin tells Lex Fridman how a hypothesized five-Earth-mass world shepherds the distant Kuiper Belt — and why a photograph would end the argument.
2:37:21ENEmma Goldman Told Lenin the Revolution Was Already WrongGuest Michael Malice · Host Lex FridmanMichael Malice talks with Lex Fridman about totalitarianism, quiet heroism, and why anarchism is a relationship rather than a place.
2:09:48ENRoger Reaves Flew Cocaine for Escobar. He Says the Money Was Never Worth ItGuest Roger Reaves · Host Lex FridmanLex Fridman talks with one of history's most prolific drug smugglers about the Medellín Cartel, Barry Seal, two shoot-downs, and 33 years in prison.
1:59:28ENSara Walker says “what is life?” is the wrong questionGuest Sara Walker · Host Lex FridmanThe astrobiologist and theoretical physicist tells Lex Fridman that origin-of-life science is stuck on molecules, and that causation, assembly, and planetary-scale information are closer to the real problem.
1:57:38ENThe Best Leadership Uses the Least ForceGuest Jocko Willink · Host Lex FridmanRetired Navy SEAL Jocko Willink talks with Lex Fridman about just war, ego, Musk and Jobs, 4 a.m. discipline, and what jiu jitsu taught him about command.
2:00:48ENNorth Korea Banned the Word for Famine. Yeonmi Park Still Says It.Guest Yeonmi Park · Host Lex FridmanA North Korean defector tells Lex Fridman how a regime hides hunger, how Animal Farm explained her country, and why she hears echoes of that silence in American life.
1:58:12ENThe Universe Doesn't Sacrifice. That's Why Phosphine Might Mean Life.Guest Clara Sousa-Silva · Host Lex FridmanQuantum astrochemist Clara Sousa-Silva on the contested Venus detection, a molecule nobody could spell, and why she treats cosmic meaninglessness as a relief.
3:17:09ENWhat Science Is Left When Institutions Decide What Cannot Be SaidGuest Bret Weinstein · Host Lex FridmanEvolutionary biologist Bret Weinstein talks with Lex Fridman about lab-leak evidence, ivermectin, captured public-health agencies, and why the 1% at the fringe is the key to progress.
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