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2:54:52ENThe Marvelous Proof Still Lives in the MarginHost Lex FridmanLuís and João Batalha, the brothers behind Fermat's Library, talk with Lex Fridman about hidden backstories, a publishing system that buys its own work twice, and how to sit with a paper until it finally clicks.
2:39:53ENThere's Something at the Edge of the Solar SystemGuest Konstantin Batygin · Host Lex FridmanCaltech planetary astrophysicist Konstantin Batygin tells Lex Fridman how a hypothesized five-Earth-mass world shepherds the distant Kuiper Belt — and why a photograph would end the argument.
1:58:12ENThe Universe Doesn't Sacrifice. That's Why Phosphine Might Mean Life.Guest Clara Sousa-Silva · Host Lex FridmanQuantum astrochemist Clara Sousa-Silva on the contested Venus detection, a molecule nobody could spell, and why she treats cosmic meaninglessness as a relief.
3:17:09ENWhat Science Is Left When Institutions Decide What Cannot Be SaidGuest Bret Weinstein · Host Lex FridmanEvolutionary biologist Bret Weinstein talks with Lex Fridman about lab-leak evidence, ivermectin, captured public-health agencies, and why the 1% at the fringe is the key to progress.
2:59:12ENNature Never Dealt This CardGuest Rob Reid · Host Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
2:41:47ENGeometry Is the Cilantro of MathGuest Jordan Ellenberg · Host Lex FridmanJordan Ellenberg tells Lex Fridman that the last 150 years of mathematics have been about one question: when two things count as the same.
1:56:54ENKatherine de Kleer still calls moons planetsGuest Katherine de Kleer · Host Lex FridmanThe Caltech planetary scientist talks with Lex Fridman about Pluto’s demotion, tidal heating on Io, hidden oceans, and the ice that may explain Oumuamua.
2:20:15ENThe virus is not meters away. It is hops away.Guest Po-Shen Loh · Host Lex FridmanPo-Shen Loh talks with Lex Fridman about teaching invention, combinatorics, and a contact-tracing app that warns you before you get sick.
2:58:38ENSleep runs on two clocks — and worrying about it can be worse than a short nightGuest Andrew Huberman · Host Lex FridmanStanford neuroscientist Andrew Huberman tells Lex Fridman how adenosine and body temperature decide when you crash, why dreams work like overnight therapy, and what the chemistry of effort has to do with not quitting.
1:44:32ENThe Philosopher’s Risk: Zev Weinstein on Stagnation, Truth, and the Courage to Change Your MindGuest Zev Weinstein · Host Lex FridmanZev Weinstein talks with Lex Fridman about why radical thought is both dangerous and necessary, and how truth, language, media, mathematics and mortality shape a meaningful life.
1:39:29ENElectric engines, 20-nanometer cones, and why Natalya Bailey would skip the first thousand on MarsGuest Natalya Bailey · Host Lex FridmanThe Accion Systems founder walks Lex Fridman from ion physics to orbital debris, chip-made thrusters, and the kind of culture that oozes out of a founder.
2:51:17ENOumuamua Wasn't Supposed to Exist. Avi Loeb Wants a Photograph Next Time.Guest Avi Loeb · Host Lex FridmanHarvard astrophysicist Avi Loeb tells Lex Fridman why the first interstellar visitor looks more like a lightsail than a rock — and why that question is still treated as unscientific.
2:18:26ENThe Dollar Paper Strip That Could Have Turned Covid's CurveGuest Michael Mina · Host Lex FridmanHarvard immunologist Michael Mina tells Lex Fridman why twice-weekly antigen tests could have reversed the pandemic—and why regulation, not manufacturing, blocked them.
2:20:31ENThe Most Romantic Gift Lisa Feldman Barrett Ever Got Was a Six-Way PlugGuest Lisa Feldman Barrett · Host Lex FridmanOn her second Lex Fridman Podcast, the neuroscientist traces how she fell in love over a 1992 bulletin board, why brains evolved to hunt rather than to think, and how a body budget can change a mood.
2:40:00ENThe Light Never Broke the Speed Limit. Space Itself Stretched.Guest Alex Filippenko · Host Lex FridmanBerkeley astrophysicist Alex Filippenko talks dark energy, exploding stars, aliens, and how a 13.7-billion-year-old universe can be 45.7 billion light-years across.
2:56:49ENEric Weinstein: Genius Is Sitting in the Wrong ChairGuest Eric Weinstein · Host Lex FridmanOn his third Lex Fridman podcast, the mathematician moves from Eddie Van Halen and Leonard Cohen to Jeffrey Epstein, the Nobel committee, and why he paused The Portal.
2:23:38ENThe Brain That Never Touches the WorldGuest Lisa Feldman Barrett · Host Lex FridmanNeuroscientist Lisa Feldman Barrett tells Lex Fridman why your skull is a dark box, why emotions are constructed like money, and why empathy is a metabolic bill.
2:10:53ENAll Your DNA Would Reach Jupiter a Hundred Times OverGuest Manolis Kellis · Host Lex FridmanManolis Kellis talks Lex Fridman through the epigenome, Neanderthals, Europa, midlife, and why "are you happy?" is the wrong question.
1:41:24ENA child can lose half a brain. The rest will rewire around the jobGuest David Eagleman · Host Lex FridmanNeuroscientist David Eagleman tells Lex Fridman why the human brain is not hardware running software, but a livewired system that never stops physically reshaping itself.
2:08:26ENSatisfying Lectures Don't Stick: Grant Sanderson on Feynman, Fear, and Hitting PublishGuest Grant Sanderson · Host Lex FridmanThe 3Blue1Brown creator talks with Lex Fridman about why the nicest explanations can fail, why he envies Bell Labs, and why the experts most qualified to teach are the ones least willing to post.
1:41:35ENThe Smallest Lights: Sara Seager on Finding Life Beyond the SunGuest Sara Seager · Host Lex FridmanThe MIT planetary scientist talks with Lex Fridman about exoplanets, biosignature gases, a flower-shaped starshade, and the grief that sent her looking for another Earth.
2:29:24ENWe Are the Descendants of the First Digital ComputerGuest Manolis Kellis · Host Lex FridmanMIT computational biologist Manolis Kellis tells Lex Fridman why life is digital, why any two humans are 99.9 percent identical, and what evolutionary signatures reveal inside SARS-CoV-2.
2:01:15ENNobody Died from the Fukushima ReactorsGuest Ian Hutchinson · Host Lex FridmanMIT plasma physicist Ian Hutchinson on fusion, a hundredfold carbon cut, scientism, and why faith is more than believing unproven claims.
1:38:20ENParticle physics is badly named: Harry Cliff on fields, the Higgs, and a collider with no bossGuest Harry Cliff · Host Lex FridmanA Cambridge physicist walks Lex Fridman through the Large Hadron Collider, the Standard Model, and why the vacuum is not empty.
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