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3:01:47ENA hundred miles is a lifetime compressed into one dayGuest Zach Bitter · Host Lex FridmanZach Bitter talks with Lex Fridman about the 100-mile mind, quitting, aerobic training, fat-adapted fueling, and a run across America.
2:13:21ENThe Fourth Deduction Often Turns Out to Be the First PrincipleGuest Cumrun Vafa · Host Lex FridmanHarvard string theorist Cumrun Vafa on why physicists distrust deduction, how a graviton fell out of a formula nobody wrote for gravity, and what extra dimensions are actually for.
1:44:54ENIf the meat needs a sauce, start over with the animalGuest Anya Fernald · Host Lex FridmanBelcampo co-founder Anya Fernald tells Lex Fridman why cooking is service, why "grass-fed" is an unregulated word, and why regenerative grazing cannot scale without human attention.
2:36:06ENThe Experience Is Not in the Pill. Rick Doblin Spent Decades Proving the Context Is.Guest Rick Doblin · Host Lex FridmanThe MAPS founder walks Lex Fridman from Huxley's reducing valve to a Phase 3 MDMA trial for PTSD, arguing that legality, safety, and culture matter more than new molecules.
2:39:53ENThere's Something at the Edge of the Solar SystemGuest Konstantin Batygin · Host Lex FridmanCaltech planetary astrophysicist Konstantin Batygin tells Lex Fridman how a hypothesized five-Earth-mass world shepherds the distant Kuiper Belt — and why a photograph would end the argument.
2:37:21ENEmma Goldman Told Lenin the Revolution Was Already WrongGuest Michael Malice · Host Lex FridmanMichael Malice talks with Lex Fridman about totalitarianism, quiet heroism, and why anarchism is a relationship rather than a place.
2:09:48ENRoger Reaves Flew Cocaine for Escobar. He Says the Money Was Never Worth ItGuest Roger Reaves · Host Lex FridmanLex Fridman talks with one of history's most prolific drug smugglers about the Medellín Cartel, Barry Seal, two shoot-downs, and 33 years in prison.
1:59:28ENSara Walker says “what is life?” is the wrong questionGuest Sara Walker · Host Lex FridmanThe astrobiologist and theoretical physicist tells Lex Fridman that origin-of-life science is stuck on molecules, and that causation, assembly, and planetary-scale information are closer to the real problem.
1:57:38ENThe Best Leadership Uses the Least ForceGuest Jocko Willink · Host Lex FridmanRetired Navy SEAL Jocko Willink talks with Lex Fridman about just war, ego, Musk and Jobs, 4 a.m. discipline, and what jiu jitsu taught him about command.
2:00:48ENNorth Korea Banned the Word for Famine. Yeonmi Park Still Says It.Guest Yeonmi Park · Host Lex FridmanA North Korean defector tells Lex Fridman how a regime hides hunger, how Animal Farm explained her country, and why she hears echoes of that silence in American life.
1:58:12ENThe Universe Doesn't Sacrifice. That's Why Phosphine Might Mean Life.Guest Clara Sousa-Silva · Host Lex FridmanQuantum astrochemist Clara Sousa-Silva on the contested Venus detection, a molecule nobody could spell, and why she treats cosmic meaninglessness as a relief.
3:17:09ENWhat Science Is Left When Institutions Decide What Cannot Be SaidGuest Bret Weinstein · Host Lex FridmanEvolutionary biologist Bret Weinstein talks with Lex Fridman about lab-leak evidence, ivermectin, captured public-health agencies, and why the 1% at the fringe is the key to progress.
1:19:49ENAll-In E37: New York’s Primary, Pandemic Origins and App Store PowerHost Jason Calacanis, Chamath Palihapitiya, David Sacks, David FriedbergA 2021 discussion of election messaging, uncertain pandemic evidence and competing views on antitrust.
2:59:12ENNature Never Dealt This CardGuest Rob Reid · Host Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
4:57:51ENCharles Hoskinson Entered Crypto Expecting PrisonGuest Charles Hoskinson · Host Lex FridmanThe Cardano founder talks with Lex Fridman about proof of stake, formal methods, and why a blockchain should behave like a law of physics.
4:15:19ENExponential tools, Stone Age game theoryGuest Daniel Schmachtenberger · Host Lex FridmanDaniel Schmachtenberger tells Lex Fridman why every leap in physical technology breaks the last social operating system — and why Bretton Woods cannot bind what comes next.
2:41:47ENGeometry Is the Cilantro of MathGuest Jordan Ellenberg · Host Lex FridmanJordan Ellenberg tells Lex Fridman that the last 150 years of mathematics have been about one question: when two things count as the same.
1:41:34ENAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGuest David Sinclair · Host Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
3:02:00ENVitalik Buterin Walked Away From Billions of Dog Coins — Then Mapped Ethereum's Next DecadeGuest Vitalik Buterin · Host Lex FridmanIn a three-hour conversation with Lex Fridman, the Ethereum co-founder explains the Shiba Inu dump, proof of stake, rollups, and why he thinks most evil comes from fear.
2:22:20ENThe closer quarks get, the weaker they pullGuest Frank Wilczek · Host Lex FridmanNobel physicist Frank Wilczek talks with Lex Fridman about asymptotic freedom, beauty, dark matter, consciousness, and whether a theory of everything would even help.
2:31:30ENThe Brain Is the Last Unengineered System in SocietyGuest Bryan Johnson · Host Lex FridmanBryan Johnson demos Kernel Flow on Lex Fridman, then argues that cognition is society's largest unmeasured input and that numbers, not vibes, should run mental health, diet, and the next wave of brain interfaces.
3:17:20ENThe illusion of free will is itself an illusionGuest Sam Harris · Host Lex FridmanSam Harris talks with Lex Fridman about consciousness, psychedelics, AI, UFOs, jiu-jitsu, and why meaning appears only when attention stops looking elsewhere.
1:56:54ENKatherine de Kleer still calls moons planetsGuest Katherine de Kleer · Host Lex FridmanThe Caltech planetary scientist talks with Lex Fridman about Pluto’s demotion, tidal heating on Io, hidden oceans, and the ice that may explain Oumuamua.
2:20:15ENThe virus is not meters away. It is hops away.Guest Po-Shen Loh · Host Lex FridmanPo-Shen Loh talks with Lex Fridman about teaching invention, combinatorics, and a contact-tracing app that warns you before you get sick.
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