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2:12:36ENAttacks Climb the Stack Until They Land on PeopleGuest Dawn Song · Host Lex FridmanDawn Song tells Lex Fridman why the next security crisis is human, how a sticker can rewrite a stop sign, and why data still has no property right.
1:14:54ENWhat Makes the Natural Logarithm Natural?Explore prime density, exponential growth, harmonic sums and the appearance of ln 2.
1:37:28ENWe Are Still Massively Underestimating Deep LearningGuest Ilya Sutskever · Host Lex FridmanIlya Sutskever tells Lex Fridman why 2012 was about conviction, why bigger models can get worse before they get better, and what he would do with an AGI.
1:12:03ENMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishGuest Daphne Koller · Host Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
1:03:07ENImaginary Interest Rates, Complex Numbers and SpringsGrant Sanderson · 3Blue1BrownA Lockdown Math lesson connects ordinary compound interest to circular motion and an oscillating spring.
1:38:20ENParticle physics is badly named: Harry Cliff on fields, the Higgs, and a collider with no bossGuest Harry Cliff · Host Lex FridmanA Cambridge physicist walks Lex Fridman through the Large Hadron Collider, the Standard Model, and why the vacuum is not empty.
51:14ENTrust, Then Verify: How Square Let 99 Percent of Merchants InGuest Jack Dorsey · Host Lex FridmanJack Dorsey tells Lex Fridman why Square is an access company, why the internet needs a native currency, and why self-awareness is being outsourced to algorithms.
2:09:02ENA Hundred-Nanometer Machine That Is Not Quite AliveGuest Dmitry Korkin · Host Lex FridmanDmitry Korkin walks through the structural genomics of SARS-CoV-2, from spike-ACE2 docking to drug-binding sites, vaccines, and cruise-ship simulations, recorded in the first spring of the pandemic.
3:11:09ENIn the computational universe, the animals are always smarter than youGuest Stephen Wolfram · Host Lex FridmanStephen Wolfram talks with Lex Fridman about Rule 30, computational irreducibility, a hypergraph model of physics, and why Wolfram Language is a notation for talking about the world.
1:05:06ENRaph Levien: GPU Compute, Functional Design, and a 2D RendererRaph LevienA tour of GPU execution and memory explains why parallel rendering needs more than simply assigning one thread to every pixel.
49:29ENThe Five Pillars of Collaborative Product OwnershipJohn Le DrewJohn Le Drew argues that teams can share product knowledge and test decisions together.
2:46:36ENThe Great Nap Is OverGuest Eric Weinstein · Host Lex FridmanMathematician Eric Weinstein tells Lex Fridman that seventy-five quiet years selected the wrong leaders, then walks through Geometric Unity, the theory he kept in a drawer for decades.
11:26ENRichard Dawkins on Memes, the Internet and Why Wrong Ideas SpreadGuest Richard Dawkins · Host Lex FridmanThe man who coined the word explains to Lex Fridman what makes a meme more than a metaphor, why the internet is a step change for ideas, and why an idea, like a peacock's tail, doesn't need to be true or useful to spread.
1:07:21ENComplex Things Have to GrowGuest Richard Dawkins · Host Lex FridmanRichard Dawkins talks with Lex Fridman about alien minds, memes, morality, and why even a simulated world would still need Darwin.
1:48:01ENDavid Silver: AlphaGo Won by Taking Human Knowledge OutGuest David Silver · Host Lex FridmanThe DeepMind researcher behind AlphaGo and AlphaZero tells Lex Fridman how an unclaimed million-dollar Go prize, a BBC Micro at age seven, and a honeymoon insight led to superhuman self-play.
1:41ENA Talk on Measuring Passion Rather Than ProgressA speaker offers a personal perspective on goals and outside advice.
1:27:57ENThe Brain's Best Computer Has No Inner LifeGuest Roger Penrose · Host Lex FridmanRoger Penrose tells Lex Fridman why HAL raises a moral problem the field will not name, why the cerebellum wrecks the computational theory of mind, and why gravity, Gödel, and an infinite cosmos all hang on the same kind of understanding.
12:42ENThe Experience Machine: What Our Refusal to Plug In Says About What We ValueGuest Nick Bostrom · Host Lex FridmanNick Bostrom unpacks Robert Nozick's experience machine, the status quo effect behind our answers, and whether a simulation convincing enough to feel real would have to contain real minds.
1:56:38ENBostrom Will Not Pick a Fork: The Simulation Argument Is a Disjunction, Not a BetGuest Nick Bostrom · Host Lex FridmanNick Bostrom walks Lex Fridman through the simulation argument, anthropic reasoning, and why superintelligence talk should be split into near-term and long-term conversations.
37:49ENYou cannot finish first in a game that has no finish lineGuest Simon Sinek · Host Lex FridmanSimon Sinek on finite versus infinite games, the legacy a career leaves, and why passion cannot be demanded.
1:38:33ENMaybe people are rational under different assumptionsGuest Anca Dragan · Host Lex FridmanAnca Dragan talks with Lex Fridman about inverse reinforcement learning, autonomous driving, and why a written reward is evidence rather than law.
17:19ENMoney Is a Game of Points: Vitalik Buterin on Coordination, Public Goods, and Quadratic FundingHost Lex FridmanVitalik Buterin explains money as a social point system, why value can survive without physical backing, and how quadratic funding tries to fix public-good underfunding.
1:35:04ENSatoshi Vanished. Vitalik Stayed Behind to Finish the Other Half.Guest Vitalik Buterin · Host Lex FridmanVitalik Buterin tells Lex Fridman what money actually is, what Satoshi invented, and why Ethereum is trying to become more than a points game.
12:34ENBinomial Distributions and the Problem of Seller RatingsHow review counts, independent trials and uncertainty about an unknown success rate fit together.
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