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45:10EN
No Priors: AI, Machine Learning, Tech, & Startups· Sep 10, 2026Podcast · 2 speakers76% of Agentic Commerce Is Under 30 Cents — So Coinbase Is Banking the AIsHost Sarah Guo, Elad GilBrian Armstrong tells Elad Gil how Coinbase became an everything exchange, why card networks cannot price agent-to-agent payments, and what his longevity company is taking into the clinic.
44:01ENNo Priors: AI, Machine Learning, Tech, & Startups· Apr 9, 2026Podcast · 2 speakersA millionth of a penny: Jeremy Allaire on the payment rails of the agentic economyHost Sarah Guo, Elad GilCircle's CEO tells No Priors why stablecoins and a purpose-built chain, not the legacy banking stack, are the money layer for software that buys and sells on its own.
48:14ENNo Priors: AI, Machine Learning, Tech, & Startups· Nov 13, 2025Podcast · 2 speakersA New Drug Burns $2 Billion and 10 Years. Benchling's CEO Wants AI to Cut That to ThreeHost Sarah Guo, Elad GilMost medicines fail in years seven to ten, after hundreds of millions have already gone into the clinic—and Sajith Wickramasekara thinks sending things to space may already be easier.
31:22ENNo Priors: AI, Machine Learning, Tech, & Startups· Sep 18, 2025Podcast · 2 speakersDecagon Prices AI Support by the Conversation. The Market Is Wages.Host Sarah Guo, Elad GilJesse Zhang on six-figure contracts at zero ARR, 60–70% contact-center cuts, and a world where your agent calls the airline’s agent.
42:12ENNo Priors: AI, Machine Learning, Tech, & Startups· Aug 21, 2025Podcast · 2 speakersHire the AI First: Andrew Ng on Agentic Workflows and the Scarcity of JudgmentHost Sarah Guo, Elad GilOn No Priors, Andrew Ng argues that agentic AI has made software cheap and fast, which moves the bottleneck to product judgment, error analysis, and the instinct to try an AI before adding headcount.
41:25ENNo Priors: AI, Machine Learning, Tech, & Startups· Jun 12, 2025Podcast · 2 speakersBen Mann thinks superintelligence by 2028 is quite possibleHost Sarah Guo, Elad GilAnthropic's co-founder tells No Priors how Claude 4 unlocked hours of unattended agent work, why the lab built Claude Code, and what an economic Turing test would actually measure.
30:46ENNo Priors: AI, Machine Learning, Tech, & Startups· Apr 24, 2025Podcast · 2 speakersDeep Research Turned Web Browsing into a Trainable ProblemHost Sarah Guo, Elad GilOpenAI researcher Isa Fulford explains why a side project on read-only synthesis became an agent, when reinforcement fine-tuning is worth it, and why models will hack the search engine you gave them.
30:09ENNo Priors: AI, Machine Learning, Tech, & Startups· Jan 16, 2025Podcast · 2 speakersBilt Saved 65 Support Seats. Decagon's Founder Says Most Agent Ideas Still Won't SellHost Sarah Guo, Elad GilJesse Zhang on why customer support is the golden agent use case, why instruction following beats o1-style reasoning, and the two filters that kill most agent startups.
39:22ENNo Priors: AI, Machine Learning, Tech, & Startups· Nov 14, 2024Podcast · 2 speakersA Fields Medalist Stuck for Two Hours. AlphaProof Climbed for Three Days.Host Sarah Guo, Elad GilThe DeepMind team behind AlphaProof tells Sarah Guo and Elad Gil how an AlphaZero-style agent, a Lean verifier, and test-time reinforcement learning reached IMO silver — and why the missing skill is still theory building.
48:31ENNo Priors: AI, Machine Learning, Tech, & Startups· Sep 19, 2024Podcast · 2 speakersA Call Center Contact Costs $13. A Company Agent Can Do It for Under a DollarHost Sarah Guo, Elad GilSierra cofounder and OpenAI chairman Bret Taylor tells No Priors why branded customer agents are shovel-ready, why RAG demos are not products, and how AI software should charge for the job done.
32:48ENNo Priors: AI, Machine Learning, Tech, & Startups· Nov 16, 2023Podcast · 2 speakersFourteen People, $200 Million of Compute, and the Reliability Bottleneck for AgentsHost Sarah Guo, Elad GilImbue co-founders Kanjun Qiu and Josh Albrecht on why agents fail, why language models cannot learn general algorithms, and why they are spending a giant round on GPUs rather than headcount.
42:25ENNo Priors: AI, Machine Learning, Tech, & Startups· Sep 15, 2023Podcast · 2 speakersThe Transformer Co-Author Who Wants to Give AI a WalletHost Sarah Guo, Elad GilIllia Polosukhin, co-author of Attention Is All You Need and co-founder of NEAR, argues that a blockchain account turns a language-model agent into an economic actor that can hire people and other AIs.
51:55ENNo Priors: AI, Machine Learning, Tech, & Startups· May 11, 2023Podcast · 2 speakersNine orders of magnitude later, he shipped a companion, not an oracleHost Sarah Guo, Elad GilDeepMind co-founder Mustafa Suleyman tells No Priors why Inflection’s first product is a personal AI that sits in your corner, and why the missing piece is a router, not a bigger model.
1:00:36ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 2, 2023Podcast · 2 speakersForty games of Diplomacy, and nobody spotted the bot: Noam Brown’s 100,000x lessonHost Sarah Guo, Elad GilMeta’s Noam Brown tells Sarah Guo and Elad Gil how Cicero negotiated in English for 40 games on a tiny web community — and why thinking at decision time beat three years of scaling.