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2:43:51ENTwo Tubes, Millimeters Apart: Jonathan Reisman on the Honest Design of the Human BodyGuest Jonathan Reisman · Host Lex FridmanThe emergency physician and author of The Unseen Body walks Lex Fridman from the throat to the Arctic, arguing that anatomy is mostly brilliant, sometimes a near-miss, and always a story written in scars.
3:21:29ENWhen something in the mind breaks, you see what it was forGuest Karl Deisseroth · Host Lex FridmanStanford psychiatrist Karl Deisseroth talks with Lex Fridman about depression, schizophrenia, optogenetics, and why you can treat one symptom without a theory of everything.
1:41:34ENAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGuest David Sinclair · Host Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:31:30ENThe Brain Is the Last Unengineered System in SocietyGuest Bryan Johnson · Host Lex FridmanBryan Johnson demos Kernel Flow on Lex Fridman, then argues that cognition is society's largest unmeasured input and that numbers, not vibes, should run mental health, diet, and the next wave of brain interfaces.
2:39:45ENThe obesity gene was never the obesity geneGuest Manolis Kellis · Host Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
1:02:14ENThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsGuest Robert Langer · Host Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:12:03ENMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishGuest Daphne Koller · Host Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
36:10ENSo You're Saying There's a Chance: Musk on Neuralink, AI, and a Pale Blue DotGuest Elon Musk · Host Lex FridmanLex Fridman and Elon Musk move from consciousness and an AI referee to the engineering of a brain implant, Tesla Autopilot, and Carl Sagan's lonely speck.
1:17:29ENThe Algorithm Is Already Better. The Clinic Still Uses 1967.Guest Regina Barzilay · Host Lex FridmanMIT's Regina Barzilay on why deep learning already beats the breast-cancer 'density' score — and why data, liability, and incentives still will not move.
1:00:11ENRosalind Picard: Clippy Never Saw You Frown, and That's the Whole ProblemGuest Rosalind Picard · Host Lex FridmanThe MIT professor who named affective computing on emotion recognition, privacy, seizure-detecting wearables, and why a device you can take off is safer than a camera you cannot see.
33:07ENThey Ran an Extension Cord Next Door and Invented GoogleGuest Eric Schmidt · Host Lex FridmanEric Schmidt tells Lex Fridman that Larry and Sergey never held the entrepreneurship meeting: they had a better algorithm, too little power in the dorm, and a $100,000 check.






