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2:36:06ENThe Experience Is Not in the Pill. Rick Doblin Spent Decades Proving the Context Is.Guest Rick Doblin · Host Lex FridmanThe MAPS founder walks Lex Fridman from Huxley's reducing valve to a Phase 3 MDMA trial for PTSD, arguing that legality, safety, and culture matter more than new molecules.
2:09:48ENRoger Reaves Flew Cocaine for Escobar. He Says the Money Was Never Worth ItGuest Roger Reaves · Host Lex FridmanLex Fridman talks with one of history's most prolific drug smugglers about the Medellín Cartel, Barry Seal, two shoot-downs, and 33 years in prison.
3:17:09ENWhat Science Is Left When Institutions Decide What Cannot Be SaidGuest Bret Weinstein · Host Lex FridmanEvolutionary biologist Bret Weinstein talks with Lex Fridman about lab-leak evidence, ivermectin, captured public-health agencies, and why the 1% at the fringe is the key to progress.
2:59:12ENNature Never Dealt This CardGuest Rob Reid · Host Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
1:41:34ENAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGuest David Sinclair · Host Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:20:15ENThe virus is not meters away. It is hops away.Guest Po-Shen Loh · Host Lex FridmanPo-Shen Loh talks with Lex Fridman about teaching invention, combinatorics, and a contact-tracing app that warns you before you get sick.
2:17:42ENThe building block of life is a bead on a string, not the whole proteinGuest Dmitry Korkin · Host Lex FridmanDmitry Korkin tells Lex Fridman why protein domains, a triangular spike, and a conservative viral shell matter more than the AlphaFold headline, and why a Nobel laureate once answered a midnight forum post.
2:18:26ENThe Dollar Paper Strip That Could Have Turned Covid's CurveGuest Michael Mina · Host Lex FridmanHarvard immunologist Michael Mina tells Lex Fridman why twice-weekly antigen tests could have reversed the pandemic—and why regulation, not manufacturing, blocked them.
3:39:01ENMatthew Johnson on loosening the priors that run a human lifeGuest Matthew Johnson · Host Lex FridmanThe Johns Hopkins psychiatrist walks Lex Fridman through receptors, addiction, DMT entities, a 15-person smoking trial, and why psychedelics have taught us almost nothing about the hard problem of consciousness.
2:39:45ENThe obesity gene was never the obesity geneGuest Manolis Kellis · Host Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
2:29:24ENWe Are the Descendants of the First Digital ComputerGuest Manolis Kellis · Host Lex FridmanMIT computational biologist Manolis Kellis tells Lex Fridman why life is digital, why any two humans are 99.9 percent identical, and what evolutionary signatures reveal inside SARS-CoV-2.
2:09:02ENA Hundred-Nanometer Machine That Is Not Quite AliveGuest Dmitry Korkin · Host Lex FridmanDmitry Korkin walks through the structural genomics of SARS-CoV-2, from spike-ACE2 docking to drug-binding sites, vaccines, and cruise-ship simulations, recorded in the first spring of the pandemic.
2:46:36ENThe Great Nap Is OverGuest Eric Weinstein · Host Lex FridmanMathematician Eric Weinstein tells Lex Fridman that seventy-five quiet years selected the wrong leaders, then walks through Geometric Unity, the theory he kept in a drawer for decades.
29:54ENSeven Levels of a Pandemic: Pain, Challenge and Hope From Biology to PhilosophyHost Lex FridmanLex Fridman maps the coronavirus onto seven levels of attack on society and proposes a response and a reason for hope at each one.









