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31:39ENThe Skull Is Already the Vat: Max Hodak on Restoring SightModeration: Sarah Guo, Elad GilPatients blinded by macular degeneration put on laser-projector glasses, read books, and fill in Sudoku — because a chip under the retina is sending vision back into the brain.
1:29:35ENFred Turner on Curative’s Pandemic Pivot, Health Insurance and AI AutomationGast: Fred Turner · Moderation: Harry StebbingsCurative’s CEO recounts building a COVID testing operation, moving into health insurance and using AI agents across the company’s workflows.
1:08:23ENShiv Rao on Building Abridge, Clinical Workflows and AIGast: Shiv Rao · Moderation: Harry StebbingsThe Abridge co-founder discusses years of market development, model choices, data trust and the limits of automating clinical work.
1:03:40ENAndrew Dudum on Hims & Hers, Preventive Care and Building a Public CompanyGast: Andrew Dudum · Moderation: Harry StebbingsThe Hims & Hers CEO discusses management, healthcare distribution, marketing and expansion. His medical and commercial claims are presented as his views, not independently verified evidence.
48:14ENA New Drug Burns $2 Billion and 10 Years. Benchling's CEO Wants AI to Cut That to ThreeModeration: Sarah Guo, Elad GilMost medicines fail in years seven to ten, after hundreds of millions have already gone into the clinic—and Sajith Wickramasekara thinks sending things to space may already be easier.
1:38:05ENHemant Taneja on Scaling General Catalyst, AI and the Future of VentureGast: Hemant Taneja · Moderation: Harry StebbingsThe General Catalyst CEO discusses early-stage returns, AI’s effect on work and the difficulty of investing through rapid technological change.
44:49ENHow OpenEvidence Became the Clinical OS for 40% of U.S. DoctorsModeration: Sarah Guo, Elad GilFounder Daniel Nadler tells No Priors how a free search tool for physicians, not an answer engine for patients, took high-stakes clinical knowledge in 18 months.
49:27ENFrom 0.1% to 20%: Chai-2 Turns Antibody Design Into Prompt EngineeringModeration: Sarah Guo, Elad GilChai Discovery co-founders Joshua Meier and Jack Dent tell Sarah Guo how a generative model now designs antibodies that bind on the first 24-well plate.
1:05ENSatya Nadella on AI, Productivity, and Cancer CareMatthew Berman, Satya Nadella · Forward FutureIn a short interview excerpt, the Microsoft CEO discusses the potential of cheaper AI to help coordinate healthcare work.
38:43ENTwo in Five Doctors Want Out. An On-Call Cardiologist Built the Note That Lets Them StayModeration: Sarah Guo, Elad GilAbridge CEO Shiv Rao on treating the doctor-patient conversation as healthcare's source of truth, and why the company ran straight at the hardest health systems.
1:16:44ENAlex Lebrun on AI Assistants for Doctors, Model Limits and Building NablaGast: Alex Lebrun · Moderation: Harry StebbingsThe Nabla co-founder explains his approach to healthcare AI, lessons from Facebook and his 2023 views on competition and regulation.
42:18ENTen Percent of Search Is Health — and the Doctor Is Googling TooModeration: Sarah Guo, Elad GilGoogle researcher Karan Singhal on Med-PaLM 2, the real bar for medical language models, and why medicine is a harder alignment lab than chatbots.
1:11:11ENEmad Mostaque on Open AI Models, National Data and the Race to DeployGast: Emad Mostaque · Moderation: Harry StebbingsThe Stability AI co-founder describes his 2023 vision for open models, healthcare applications and AI businesses, alongside concerns about a speculative boom.
46:57EN95% of Drug Programs Fail. Daphne Koller Is Betting Machine Learning on the First DecisionModeration: Sarah Guo, Elad GilA new medicine still takes more than a decade and well over a billion dollars — and Insitro's founder argues the expensive failures start with the wrong target, indication, or patient.
50:12ENThe Drone Is Only 15 Percent of the ProblemModeration: Sarah Guo, Elad GilZipline CEO Keller Rinaudo Cliffton on why blood delivery in Rwanda, not a cooler airplane, built the world's largest commercial autonomous system.
2:43:51ENTwo Tubes, Millimeters Apart: Jonathan Reisman on the Honest Design of the Human BodyGast: Jonathan Reisman · Moderation: Lex FridmanThe emergency physician and author of The Unseen Body walks Lex Fridman from the throat to the Arctic, arguing that anatomy is mostly brilliant, sometimes a near-miss, and always a story written in scars.
3:21:29ENWhen something in the mind breaks, you see what it was forGast: Karl Deisseroth · Moderation: Lex FridmanStanford psychiatrist Karl Deisseroth talks with Lex Fridman about depression, schizophrenia, optogenetics, and why you can treat one symptom without a theory of everything.
1:41:34ENAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGast: David Sinclair · Moderation: Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:31:30ENThe Brain Is the Last Unengineered System in SocietyGast: Bryan Johnson · Moderation: Lex FridmanBryan Johnson demos Kernel Flow on Lex Fridman, then argues that cognition is society's largest unmeasured input and that numbers, not vibes, should run mental health, diet, and the next wave of brain interfaces.
2:39:45ENThe obesity gene was never the obesity geneGast: Manolis Kellis · Moderation: Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
1:02:14ENThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsGast: Robert Langer · Moderation: Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:12:03ENMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishGast: Daphne Koller · Moderation: Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
36:10ENSo You're Saying There's a Chance: Musk on Neuralink, AI, and a Pale Blue DotGast: Elon Musk · Moderation: Lex FridmanLex Fridman and Elon Musk move from consciousness and an AI referee to the engineering of a brain implant, Tesla Autopilot, and Carl Sagan's lonely speck.
1:17:29ENThe Algorithm Is Already Better. The Clinic Still Uses 1967.Gast: Regina Barzilay · Moderation: Lex FridmanMIT's Regina Barzilay on why deep learning already beats the breast-cancer 'density' score — and why data, liability, and incentives still will not move.
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