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38:14ENDiffusion Will Win Inference: Stefano Ermon Bets Parallel Tokens Beat Custom SiliconModeration: Sarah Guo, Elad GilThe Stanford diffusion pioneer tells No Priors why a 50-person lab is training language models that generate many tokens at once — and why that maps to GPUs the way transformers once mapped to training.
36:58ENSTaR's Author Wants Models With EQ, Not Just More IQModeration: Sarah Guo, Elad GilEric Zelikman, the Stanford and xAI researcher behind STaR and Quiet-STaR, launches humans& on the bet that three years of IQ scaling left models emotionally unintelligent.
13:30ENHow AlphaGeometry Combines Logical Proof with Creative ConstructionAleph0Aleph0 explains how a symbolic geometry solver gets surprisingly far without AI, and how a language model supplies the auxiliary constructions that take it to Olympiad level.
38:10ENo3 should wait exactly as long as the answer takesModeration: Sarah Guo, Elad GilOpenAI researchers Eric Mitchell and Brandon McKinzie tell No Priors why o3's leap is a chain of tools during reasoning — and why you should send the same prompt a hundred times.
35:14ENRobots Have No Wikipedia. Chelsea Finn Is Starting With Three Buildings.Moderation: Sarah Guo, Elad GilPhysical Intelligence’s cofounder tells No Priors why a generalist robot model has to be trained across embodiments, why open-sourcing hardware is a bet against the problem going unsolved, and why humanoids are a little overrated.
57:41ENA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentModeration: Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
22:32ENThe $5.5 Million Was Only the Last MileModeration: Sarah Guo, Elad GilOn No Priors' 100th episode, Sarah Guo and Elad Gil separate DeepSeek's paper cost from the compute behind it, then walk through OpenAI's Deep Research, Stargate, and their bets for 2025.
5:15:00ENDario Amodei Has Seen This Scaling Movie Enough TimesGast: Dario Amodei · Moderation: Lex FridmanAnthropic’s CEO puts numbers on frontier training costs and AGI, then hands the mic to the people who shape Claude’s character and look inside its weights.
46:09ENOriol Vinyals: The Days of Burning 90% of Compute on Pretraining Are NumberedModeration: Sarah Guo, Elad GilGoogle DeepMind’s VP of research on Gemini, long context, the coming shift from pretraining to RL, and why AGI may never have a finish line.
34:09ENFive Independent Teams Found the Same 10-to-1 Mix That Beats TransformersModeration: Sarah Guo, Elad GilThe authors of S4 and Mamba argue that mostly state-space layers plus a dash of attention is the architecture that actually works—and they are shipping it first as real-time speech.
2:47:17ENIf You Want Human-Level AI, Abandon Generative ModelsGast: Yann Lecun · Moderation: Lex FridmanYann LeCun tells Lex Fridman why autoregressive LLMs cannot plan, remember, or understand the physical world — and why open source is the only democratic answer.
40:58EN99% of Factory Robots Are Dumb. Covariant Wants the Smart Ones Working in Warehouses FirstModeration: Sarah Guo, Elad GilFormer OpenAI researcher Peter Chen explains why robot foundation models have to be trained on production floors, not in labs.
41:58ENReliability is the bottleneck. Autonomy is what would make AI feel alive.Moderation: Sarah Guo, Elad GilIlya Sutskever talks with Sarah Guo and Elad Gil about AlexNet, OpenAI’s capped-profit bet, why smaller models mainly lose reliability, and the line he draws for digital life.
37:01ENDNA Is Code, but You Compile It with a PipetteModeration: Sarah Guo, Elad GilGinkgo Bioworks CEO Jason Kelly tells No Priors why cells are worth the magic, why biology has no AWS, and why a pandemic should look like cybersecurity.
35:24ENThe Author of Attention Is All You Need Now Compiles mRNA Like BytecodeModeration: Sarah Guo, Elad GilJakob Uszkoreit on why Transformers won, why models spend compute on the wrong things, and why drug discovery has to become generation rather than screening.
42:18ENTen Percent of Search Is Health — and the Doctor Is Googling TooModeration: Sarah Guo, Elad GilGoogle researcher Karan Singhal on Med-PaLM 2, the real bar for medical language models, and why medicine is a harder alignment lab than chatbots.
4:14:33ENThe Next Token Is Not a Proof: Stephen Wolfram on ChatGPT and Computational TruthGast: Stephen Wolfram · Moderation: Lex FridmanIn his fourth conversation with Lex Fridman, Stephen Wolfram contrasts large language models with Wolfram|Alpha, then follows computational irreducibility from ChatGPT through observers, thermodynamics, and the three great theories of twentieth-century physics.
40:25ENA 6-Billion-Parameter Clone of ChatGPT’s Core TrickModeration: Sarah Guo, Elad GilDatabricks CTO Matei Zaharia tells Sarah Guo and Elad Gil how Dolly learned instruction-following on fifty times less data than GPT-3 — and why he would rather look facts up than bake them into a trillion-parameter network.
3:28:47ENKarpathy Calls Trained Neural Nets Complicated Alien ArtifactsGast: Andrej Karpathy · Moderation: Lex FridmanOn Lex Fridman's podcast, Andrej Karpathy refuses the brain analogy, walks the Fermi paradox through Nick Lane's chemistry, and treats the Transformer as a general-purpose differentiable computer.
2:10:08ENGato Is Only the BeginningGast: Oriol Vinyals · Moderation: Lex FridmanDeepMind's Oriol Vinyals talks with Lex Fridman about generalist agents, thrown-away weights, and whether human-level AGI arrives in his lifetime.
2:10:39ENDemis Hassabis: Solve Intelligence, Then Solve Everything ElseGast: Demis Hassabis · Moderation: Lex FridmanThe DeepMind CEO tells Lex Fridman why the Turing Test is the wrong exam, how AlphaFold rewrote biology, and why the quiet radio sky suggests we are probably alone.
2:45:10ENA Teenager Learns to Drive in Twenty Hours. A Car Still Cannot.Gast: Yann Lecun · Moderation: Lex FridmanYann LeCun tells Lex Fridman why self-supervised world models are the missing dark matter of intelligence, and why machines are not even at the level of a house cat.
2:31:57ENJay McClelland on How Thought Emerges From Neural NetworksGast: Jay McClelland · Moderation: Lex FridmanThe Stanford cognitive scientist talks with Lex Fridman about connectionism, backpropagation, David Rumelhart, and why intuition discovers what logic later proves.
2:51:33ENThe Self Is a GPT Prompt: Wojciech Zaremba on Consciousness, Codex, and Fermi's SilenceGast: Wojciech Zaremba · Moderation: Lex FridmanOpenAI co-founder Wojciech Zaremba tells Lex Fridman he thinks we might be alone in the universe — and that GPT-3, Codex, and a one-handed robot already hint at how intelligence is built.
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