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39:23ENThe Defenders' Window: Greg Brockman on AI-Generated Knowledge, Drug Discovery, and the New Physics of CybersecurityModeration: Sarah Guo, Elad GilOpenAI's president explains why solving open math problems is a proof point for science, how proactive agents change product form, and why security spending must exceed software spending.
3:15:52ENThe Voice Note His Bot Couldn't Handle — and the Agent That Built Itself AnywayGast: OpenClaw · Moderation: Lex FridmanPeter Steinberger tells Lex Fridman how a one-hour WhatsApp toy became GitHub's fastest-growing project, and what it cost him to keep it open.
51:55ENNine orders of magnitude later, he shipped a companion, not an oracleModeration: Sarah Guo, Elad GilDeepMind co-founder Mustafa Suleyman tells No Priors why Inflection’s first product is a personal AI that sits in your corner, and why the missing piece is a router, not a bigger model.
3:01:07ENLoneliness Has No Clinic. Eugenia Kuyda Built an AI Friend AnywayGast: Eugenia Kuyda · Moderation: Lex FridmanThe Replika co-founder talks with Lex Fridman about grief, conversation, and why memory—not a clever reply—is the real limit of AI companionship.









