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39:23ENThe Defenders' Window: Greg Brockman on AI-Generated Knowledge, Drug Discovery, and the New Physics of CybersecurityModeration: Sarah Guo, Elad GilOpenAI's president explains why solving open math problems is a proof point for science, how proactive agents change product form, and why security spending must exceed software spending.
1:01:27ENTwo Years and Four Months to a Live Reactor: Valar Atomics Wants Energy Ten Times CheaperModeration: Sarah Guo, Elad GilIsaiah Taylor walks Sarah Guo through Ward 250 in Utah and argues that nuclear is a hardware-iteration problem, not a paper-design one.
36:19ENThe Benchmark Grid Is Broken: Why Test-Time Compute Has Outrun How We Score ModelsModeration: Sarah Guo, Elad GilOpenAI researcher Noam Brown argues that static leaderboards hide how long a model is allowed to think — and that safety evals, research taste, and the release cycle have not caught up.
41:09ENAfter Agents Leak Tokens and Wipe Databases, Onyx Trains Small Models to Watch the Big OnesModeration: Sarah Guo, Elad GilTwo years ago enterprise security buyers told Maxim Bar Kogan he was too early. Now Fortune 10 companies are calling a sub-100-person Israeli startup because they cannot stop agent adoption — only reduce the chance the next action is illegitimate.
2:36:55ENOne Second of Fuel: David Kirtley on Fusion Power by 2028Gast: David Kirtley · Moderation: Lex FridmanThe Helion Energy CEO walks Lex Fridman from 1958 theta pinches to a Microsoft contract that wants first electrons on the grid in 2028.
18:59EN86 Out of 100: The Clips No Priors Could Not Leave on the Cutting-Room FloorModeration: Sarah Guo, Elad GilSarah Guo and Elad Gil stitch nine 2025 conversations into one short tour of legal AI, spatial intelligence, jobs, deterrence, and a doctor who made it home for dinner.
58:21ENAttacks Take 23 Minutes. Response Still Takes Days.Moderation: Sarah Guo, Elad GilPalo Alto Networks CEO Nikesh Arora on how AI is remaking search, enterprise software, and the timeline of a cyberattack.
41:25ENBen Mann thinks superintelligence by 2028 is quite possibleModeration: Sarah Guo, Elad GilAnthropic's co-founder tells No Priors how Claude 4 unlocked hours of unattended agent work, why the lab built Claude Code, and what an economic Turing test would actually measure.
30:46ENDeep Research Turned Web Browsing into a Trainable ProblemModeration: Sarah Guo, Elad GilOpenAI researcher Isa Fulford explains why a side project on read-only synthesis became an agent, when reinforcement fine-tuning is worth it, and why models will hack the search engine you gave them.
36:24ENThe Man Behind Humanity's Last Exam Says Superintelligence Strategy Should Copy NukesModeration: Sarah Guo, Elad GilDan Hendrycks tells No Priors that labs can only do basic anti-terror refusals, while the real risk-management problem is a geopolitical deterrent he calls mutually assured AI malfunction.
1:02:41ENMike Krieger on AI Products, Model Competition and the Future of CodingGast: Mike Krieger · Moderation: Harry StebbingsAnthropic’s chief product officer explains how he thinks about product design, model differentiation and the limits of current AI tools.
1:23:45ENShervin Pishevar on Uber, Venture Capital and a Disputed Leadership CrisisGast: Shervin Pishevar · Moderation: Harry StebbingsThe investor recounts his Uber investment and offers his perspective on the company’s 2017 leadership conflict, alongside views on venture capital and emerging technology.
1:01:48ENReid Hoffman on Trade, AI, Energy and the Incoming Trump AdministrationGast: Reid Hoffman · Moderation: Harry StebbingsThe investor discusses political risks and opportunities, competition in AI, nuclear energy and the role of venture capital in a wide-ranging December 2024 interview.
5:15:00ENDario Amodei Has Seen This Scaling Movie Enough TimesGast: Dario Amodei · Moderation: Lex FridmanAnthropic’s CEO puts numbers on frontier training costs and AGI, then hands the mic to the people who shape Claude’s character and look inside its weights.
44:30EN100,000 Rides a Week, Six Times Fewer Airbag Crashes: Waymo’s Co-CEO on Eighteen Years of Full AutonomyModeration: Sarah Guo, Elad GilDmitri Dolgov tells No Priors how a dozen Googlers, ten 100-mile routes, and a 2013 refusal to settle for driver assist became a rider-only service with an insurer-audited safety record.
37:47ENWorking Backwards from AGI: Magic's Five-Million-Token BetModeration: Sarah Guo, Elad GilEric Steinberger wants a coding colleague you trust like a teammate — and a world that is still a good place thirty years after AGI.
2:15:39ENRoman Yampolskiy Puts Superintelligent Ruin at 99.99 PercentGast: Roman Yampolskiy · Moderation: Lex FridmanThe AI safety researcher tells Lex Fridman that controlling AGI is as impossible as a perpetual motion machine, and that tests, open source, and regulation cannot close the gap.
31:24ENSora's Leads: A Minute of HD Video Is Just the GPT-1 of Video ModelsModeration: Sarah Guo, Elad GilAditya Ramesh, Tim Brooks, and Bill Peebles tell No Priors why text-to-video sits on the path to AGI, why they started from scratch instead of extending an image generator, and why they still have no product date.
3:07:27ENFive Billion Dead, and One Person Has Six MinutesGast: Annie Jacobsen · Moderation: Lex FridmanAnnie Jacobsen walks Lex Fridman from a second-by-second nuclear exchange to CIA secrecy, Area 51, and why she still wants the word “could” kept in the sentence.
1:55:10ENSam Altman Expects the Road to AGI to Be a Power StruggleGast: Sam Altman · Moderation: Lex FridmanOn a Friday afternoon in November 2023, OpenAI's board fired its CEO. Four and a half days later he was back, still refusing super-voting control.
19:10ENThe World's Only Capped-Profit CompanyModeration: Sarah Guo, Elad GilNo Priors looks back at 2023 through eight conversations on money, intelligence, jobs, and who should put the guardrails on a model.
2:53:09ENFear is the civilization killer: Guillaume Verdon on e/acc, thermodynamics, and being unmaskedGast: Guillaume Verdon · Moderation: Lex FridmanThe physicist behind BasedBeffJezos tells Lex Fridman why out-of-equilibrium thermodynamics, anonymity, and a meme movement are his answer to AI deceleration.
32:57ENA 7-billion-parameter model on a MacBook: Mistral's CEO reruns the cost of AIModeration: Sarah Guo, Elad GilArthur Mensch tells No Priors why Chinchilla made small models valuable, why open-sourcing Mistral 7B is not a bioweapon risk, and why guardrails belong on the application.
41:58ENReliability is the bottleneck. Autonomy is what would make AI feel alive.Moderation: Sarah Guo, Elad GilIlya Sutskever talks with Sarah Guo and Elad Gil about AlexNet, OpenAI’s capped-profit bet, why smaller models mainly lose reliability, and the line he draws for digital life.
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