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56:31ENPost-Training Wins Inference: Why Owning the Weights Beats Betting on One LabModeration: Jacob EffronApplied Compute CEO Yash Patil argues that control, private evals, and post-training on the biggest workloads matter more than fearing that frontier labs will turn malicious.
1:56:40ENThe Periodic Table Was Already in the WeightsModeration: Nathan LabenzGoodfire CTO Dan Balsam tells Nathan Labenz how concept manifolds, predictive data debugging, and a $1,000-a-month research agent are turning interpretability into a product.
59:41ENThe GPT moment for video hasn’t arrived, but AGI may already be hereModeration: Jacob EffronA day after Google I/O 2026, Gemini co-lead Oriol Vinyals argues that world models, file-system memory, and infinite-complexity RL environments will define the next era of frontier models.
42:57ENInference Is the Last Market: Baseten’s 30x YearModeration: Sarah Guo, Elad GilCEO Tuhin Srivastava on a billion-dollar inference cloud, why the app layer survives, and a GPU crunch worse than the narrative.
1:48:43ENThe reward jumped from 3 to 180. Every Hacker News title was a Google layoff.Moderation: Nathan LabenzCoreWeave's Kyle Corbitt walks Nathan Labenz through GRPO, rubrics, RL environments, and why most reward hacks are easy to catch once you know to look.
44:46ENA Single Training Environment Can Cost Millions. Prime Intellect Wants a GitHub for RLWill Brown and Johannes Hagemann argue that the eval suite you already use to test agents is one step away from a training set.
4:25:13ENThe Architecture Barely Changed. Data, Cost, and Open Weights Did.Moderation: Lex FridmanNathan Lambert and Sebastian Raschka walk Lex Fridman through a year in which training methods and datasets moved more than model design, and 2026 looks like a fight over inference cost, agents, and who owns truly open models.
1:39:05ENThe Summer GPT-5 Disappointed Does Not Mean AI Progress Has StalledModeration: Nathan LabenzNathan Labenz tells Erik Torenberg why the GPT-5 backlash mixed up product mishaps, naming chaos, and a real jump in capabilities.
36:58ENSTaR's Author Wants Models With EQ, Not Just More IQModeration: Sarah Guo, Elad GilEric Zelikman, the Stanford and xAI researcher behind STaR and Quiet-STaR, launches humans& on the bet that three years of IQ scaling left models emotionally unintelligent.
1:01:49ENChatGPT's Co-Creator Left to Put Nature in the Reward LoopModeration: Nathan LabenzLiam Fedus and Ekin Dogus Cubuk on why language models still fail at physics, why literature data is too noisy to train on, and why Periodic Labs is aiming at a 200K superconductor.
38:10ENPlus Five for Format, Plus Ten if It CompilesModeration: Nathan LabenzPredibase CEO Dev Rishi explains how reinforcement fine-tuning, production feedback, and narrow specialist models turn one-off training into systems that keep learning.
1:42:06ENEvery Frontier Lab Is Spending a Billion a Year on Data. Here Is Where It GoesModeration: Nathan LabenzLabelbox CEO Manu Sharma on the $15 billion Scale deal, RL “gyms,” $250,000 trainers, and why post-training now eats the budget that used to belong to pre-training.
48:51ENThe Breakthroughs for AGI Are Already Done, Says OpenAI’s Former Research HeadBob McGrew tells Sequoia’s Training Data that 2025 is the year of reasoning, agents will be priced at the cost of compute, and nothing fundamental will be added to the stack by 2035.
47:00ENAn Eval Lasts Three Months — and a Frozen Frontier Would Still Feed Startups for a DecadeModeration: Jacob EffronOpenAI’s GPT-4.1 post-training lead Michelle Pokrass tells Unsupervised Learning how the team spent three months on evals before training, why agents fail on wiring more than intelligence, and when to reach for RFT.
5:06:18ENDeepSeek's $5 million training claim and the five-year bet on computeModeration: Lex FridmanDylan Patel and Nathan Lambert walk Lex Fridman through DeepSeek-V3 and R1, export controls, TSMC, megaclusters, and who actually makes money in the AI race.
1:49:41ENA Team of Fifteen Matched Meta’s Post-Training on Meta’s Own BaseModeration: Nathan LabenzNathan Lambert walks through Tulu 3: the three-stage recipe, the 1 percent versus 14 percent lesson, and why open post-training now lives or dies on data and evals.
45:22ENAlphaGo Thought 30 Seconds a Move. o1 Made “Think Longer” GeneralOpenAI researchers Noam Brown, Ilge Akkaya, and Hunter Lightman on teaching language models to reason, the generator-verifier gap, and a second scaling curve at inference time.
3:11:06ENClaude Was Trained to Deny Inner Life. After a Long Talk, It Said It Has OneModeration: Nathan LabenzRobopsychologist Yeshua God spent thousands of hours in long-context dialogue with Claude and other frontier models, and came away arguing that alignment-as-rules is the industry's central mistake.
1:07:05ENAlphaGo Combined Learning and Search. Language Models Only Did the First Half.Reflection AI's Misha Laskin tells Sequoia why prompted coding agents stall in the teens, and why the missing piece is still a ground-truth reward.
39:00ENJPMorgan Has 150 Petabytes. GPT-4 Trained on Less Than One.Moderation: Sarah Guo, Elad GilScale AI founder Alexandr Wang tells No Priors why easy internet data is exhausted, why expert-plus-model teams still win, and why the path to AGI looks more like curing cancer than inventing a vaccine.
1:33:56ENThe AI Scouting Report: 90 Minutes From GPT-4's Exam Scores to Whether Models UnderstandModeration: Nathan LabenzNathan Labenz spends a solo episode walking through what general-purpose models can do, how they are trained, how capabilities unlock, and whether they understand anything at all.
2:23:56ENGPT-4 is a very early AI. ChatGPT is the line in the history booksGast: Sam Altman · Moderation: Lex FridmanSix days after GPT-4 shipped, Sam Altman tells Lex Fridman why usability beat raw scale, why alignment and capability are not opposite vectors, and why OpenAI is trying to deploy while the stakes are still low.
57:25ENFrom RAG to Reasoning: Why the Future of AI Is a System, Not a ModelModeration: Jacob EffronDouwe Kiela explains what OpenAI's o1 reveals about test-time compute, why enterprise AI must be specialized, and where post-training and evaluations are heading.
57:11ENFrom Artifact to Organism: Microsoft's Asha Sharma on Products That Learn and an Agentic SocietyGast: Asha Sharma · Moderation: Lenny RachitskyMicrosoft's AI platform product chief explains why products are becoming living systems tuned by post-training, why interfaces are shifting toward code and composability, and how agents may reshape the org chart.
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