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1:48:29ENHow AI Is Changing Programming: John Krazit and Ron MinskyRon Minsky, John Krazit · Jane StreetJane Street’s AI tooling lead and the Signals and Threads host examine agent infrastructure, security, code review and the changing experience of writing software.
39:23ENThe Defenders' Window: Greg Brockman on AI-Generated Knowledge, Drug Discovery, and the New Physics of CybersecurityModeration: Sarah Guo, Elad GilOpenAI's president explains why solving open math problems is a proof point for science, how proactive agents change product form, and why security spending must exceed software spending.
41:09ENAfter Agents Leak Tokens and Wipe Databases, Onyx Trains Small Models to Watch the Big OnesModeration: Sarah Guo, Elad GilTwo years ago enterprise security buyers told Maxim Bar Kogan he was too early. Now Fortune 10 companies are calling a sub-100-person Israeli startup because they cannot stop agent adoption — only reduce the chance the next action is illegitimate.
1:14:08ENLovable CEO Anton Osika on AI App Building, Economics and SecurityGast: Anton Osika · Moderation: Harry StebbingsOsika discusses Lovable’s reported growth, model costs and product strategy while Stebbings challenges its defensibility and security.
36:24ENThe Man Behind Humanity's Last Exam Says Superintelligence Strategy Should Copy NukesModeration: Sarah Guo, Elad GilDan Hendrycks tells No Priors that labs can only do basic anti-terror refusals, while the real risk-management problem is a geopolitical deterrent he calls mutually assured AI malfunction.
48:30ENGuy Podjarny on AI Coding Tools and the Future of Software DevelopmentGast: Guy Podjarny · Moderation: Harry StebbingsThe Tessl CEO examines coding assistants, agentic development, security and the business choices surrounding AI.
2:15:39ENRoman Yampolskiy Puts Superintelligent Ruin at 99.99 PercentGast: Roman Yampolskiy · Moderation: Lex FridmanThe AI safety researcher tells Lex Fridman that controlling AGI is as impossible as a perpetual motion machine, and that tests, open source, and regulation cannot close the gap.
3:07:27ENFive Billion Dead, and One Person Has Six MinutesGast: Annie Jacobsen · Moderation: Lex FridmanAnnie Jacobsen walks Lex Fridman from a second-by-second nuclear exchange to CIA secrecy, Area 51, and why she still wants the word “could” kept in the sentence.
36:22ENOne Attacker and a For Loop: Why Email Is Still the Softest Target in an AI Arms RaceModeration: Sarah Guo, Elad GilMaterial Security co-founder Ryan Noon on how 2016 election hacks, Google and Microsoft's email duopoly, and large language models are rewriting both sides of cybersecurity.
2:48:12ENThe Asteroid We Are Building OurselvesGast: Max Tegmark · Moderation: Lex FridmanPhysicist Max Tegmark tells Lex Fridman why a six-month pause on models larger than GPT-4 is not a ban on AI, but a chance to stop a suicide race.
3:17:51ENWhoops is the sound of getting less wrong: Yudkowsky, two weeks after GPT-4Gast: Eliezer Yudkowsky · Moderation: Lex FridmanTwo weeks after GPT-4 launched, Eliezer Yudkowsky sat down with Lex Fridman and started by admitting the transformer stack had already gone further than he expected.
2:56:02ENThe FBI Never Cracked a Password the Day They Took Silk RoadGast: Chris Tarbell · Moderation: Lex FridmanFormer agent Chris Tarbell tells Lex Fridman how a timezone setting, a Gmail address, and an undercover admin brought down Ross Ulbricht — and why the best hackers are still out there.
3:35:40ENLiv Boeree on Moloch, Useful Fictions, and Why Luck Keeps Poker AliveGast: Liv Boeree · Moderation: Lex FridmanThe poker champion and science educator talks with Lex Fridman about game theory, attention, simulation, aliens, and the existential races that look like games nobody can quit.
3:53:09ENThe CIA Serves One Customer, and That Customer Is the PresidentGast: Andrew Bustamante · Moderation: Lex FridmanFormer covert officer Andrew Bustamante walks Lex Fridman through how American intelligence actually works — from the President's Daily Brief to Ukraine, Snowden, and a bar wall in Alabama.
3:47:25ENThe Original Internet Godfather Built Trust Among CybercriminalsGast: Brett Johnson · Moderation: Lex FridmanLex Fridman talks with Brett Johnson about ShadowCrew, social engineering, prison, and why most attacks still use holes everyone already knows about.
2:01:35ENA no-click iPhone exploit sold for $2.5 million. Silence was the only condition.Gast: Nicole Perlroth · Moderation: Lex FridmanNicole Perlroth tells Lex Fridman how zero-days, ransomware, and a privately owned power grid turned curiosity into everyday cyberwar.
2:31:48ENA Car That Cannot Drive Itself Will Be About as Useful as a HorseGast: Elon Musk · Moderation: Lex FridmanIn a Lex Fridman conversation built around Tesla Autopilot, Elon Musk argues that every driver input is an error, that today’s hardware is already enough for full self-driving, and that watching the human will soon matter less than making the system safer than a person.
2:59:12ENNature Never Dealt This CardGast: Rob Reid · Moderation: Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
4:15:19ENExponential tools, Stone Age game theoryGast: Daniel Schmachtenberger · Moderation: Lex FridmanDaniel Schmachtenberger tells Lex Fridman why every leap in physical technology breaks the last social operating system — and why Bretton Woods cannot bind what comes next.
1:53:41ENSilvio Micali: Money Is a Shared Belief, and a Blockchain Makes It Common KnowledgeGast: Silvio Micali · Moderation: Lex FridmanThe Turing Award cryptographer and Algorand founder tells Lex Fridman why ledgers, lotteries, and one-way functions matter more than mining.
3:02:43ENHumanity Cannot Survive on the Right Person Showing Up at the Right TimeGast: Max Tegmark · Moderation: Lex FridmanMIT physicist Max Tegmark tells Lex Fridman why AI should be as well understood as rockets, why 2020 was a warning on weapons and news, and why luck is a terrible long-term plan.
2:12:36ENAttacks Climb the Stack Until They Land on PeopleGast: Dawn Song · Moderation: Lex FridmanDawn Song tells Lex Fridman why the next security crisis is human, how a sticker can rewrite a stop sign, and why data still has no property right.
1:39:57ENPeople Say They Want Perfect Robots. They Trust the Ones That Push BackGast: Ayanna Howard · Moderation: Lex FridmanAyanna Howard on human-robot interaction, the ethics of safety-critical code, and why a little imperfection is what actually earns trust.
1:48:55ENThree Fairness Rules That Cannot All Be TrueGast: Michael Kearns · Moderation: Lex FridmanMichael Kearns tells Lex Fridman why algorithmic fairness is messier than privacy, and why a Pareto curve belongs in front of the people who actually have to choose.
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