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39:23EN
No Priors: AI, Machine Learning, Tech, & Startups· 15. Okt. 2026Podcast · 2 StimmenThe Defenders' Window: Greg Brockman on AI-Generated Knowledge, Drug Discovery, and the New Physics of CybersecurityModeration: Sarah Guo, Elad GilOpenAI's president explains why solving open math problems is a proof point for science, how proactive agents change product form, and why security spending must exceed software spending.
48:14ENNo Priors: AI, Machine Learning, Tech, & Startups· 13. Nov. 2025Podcast · 2 StimmenA New Drug Burns $2 Billion and 10 Years. Benchling's CEO Wants AI to Cut That to ThreeModeration: Sarah Guo, Elad GilMost medicines fail in years seven to ten, after hundreds of millions have already gone into the clinic—and Sajith Wickramasekara thinks sending things to space may already be easier.
49:27ENNo Priors: AI, Machine Learning, Tech, & Startups· 3. Juli 2025Podcast · 2 StimmenFrom 0.1% to 20%: Chai-2 Turns Antibody Design Into Prompt EngineeringModeration: Sarah Guo, Elad GilChai Discovery co-founders Joshua Meier and Jack Dent tell Sarah Guo how a generative model now designs antibodies that bind on the first 24-well plate.
42:09ENNo Priors: AI, Machine Learning, Tech, & Startups· 26. Juni 2025Podcast · 2 StimmenAlphaEvolve found algorithms humans missed for 50 years — then sped up Gemini 23%Moderation: Sarah Guo, Elad GilGoogle DeepMind’s Pushmeet Kohli and Matej Balog tell No Priors how an evolutionary coding agent searches algorithm space the way AlphaGo searched Go.
40:54ENNo Priors: AI, Machine Learning, Tech, & Startups· 17. Apr. 2025Podcast · 2 StimmenDiscovery rates collapsed tenfold. KoBold still found a 5% copper depositModeration: Sarah Guo, Elad GilJosh Goldman explains why KoBold Metals treats mineral exploration as an information problem, pairing AI with century-old maps to hunt lithium and copper.
40:33ENNo Priors: AI, Machine Learning, Tech, & Startups· 27. Feb. 2025Podcast · 2 StimmenModerna was only company 18. The real product is the company factoryModeration: Sarah Guo, Elad GilNoubar Afeyan tells No Priors how Flagship Pioneering turned starting companies into a profession, underwrites scientific uncertainty, and wants AI to run discovery the way Waymo drives.
57:41ENNo Priors: AI, Machine Learning, Tech, & Startups· 25. Feb. 2025Podcast · 2 StimmenA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentModeration: Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
39:22ENNo Priors: AI, Machine Learning, Tech, & Startups· 14. Nov. 2024Podcast · 2 StimmenA Fields Medalist Stuck for Two Hours. AlphaProof Climbed for Three Days.Moderation: Sarah Guo, Elad GilThe DeepMind team behind AlphaProof tells Sarah Guo and Elad Gil how an AlphaZero-style agent, a Lean verifier, and test-time reinforcement learning reached IMO silver — and why the missing skill is still theory building.
37:01ENNo Priors: AI, Machine Learning, Tech, & Startups· 28. Sept. 2023Podcast · 2 StimmenDNA Is Code, but You Compile It with a PipetteModeration: Sarah Guo, Elad GilGinkgo Bioworks CEO Jason Kelly tells No Priors why cells are worth the magic, why biology has no AWS, and why a pandemic should look like cybersecurity.
35:24ENNo Priors: AI, Machine Learning, Tech, & Startups· 24. Aug. 2023Podcast · 2 StimmenThe Author of Attention Is All You Need Now Compiles mRNA Like BytecodeModeration: Sarah Guo, Elad GilJakob Uszkoreit on why Transformers won, why models spend compute on the wrong things, and why drug discovery has to become generation rather than screening.
46:57ENNo Priors: AI, Machine Learning, Tech, & Startups· 2. März 2023Podcast · 2 Stimmen95% of Drug Programs Fail. Daphne Koller Is Betting Machine Learning on the First DecisionModeration: Sarah Guo, Elad GilA new medicine still takes more than a decade and well over a billion dollars — and Insitro's founder argues the expensive failures start with the wrong target, indication, or patient.
56:20ENNo Priors: AI, Machine Learning, Tech, & StartupsPodcast · 2 StimmenBiohub's Bet: Building Open AI World Models of Biology From Proteins Up to CellsModeration: Sarah Guo, Elad GilMark Zuckerberg, Priscilla Chan and Alex Rives explain why Biohub pairs a frontier AI lab with frontier wet-lab biology, and why it releases tools like ESMFold2 as open source.