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45:46ENGiving AI a Nervous System: Voice, Touch, and the Post-Keyboard InterfaceModeration: Jacob EffronLiveKit's Russ explains how voice AI, multimodal chat, cloud browsers, and on-device models are reshaping how humans work with machines.
13:58ENDeep Reinforcement Learning, Explained by the Researcher Behind AlphaGoModeration: Lex FridmanDavid Silver of DeepMind walks through what reinforcement learning is, how its building blocks fit together, and why deep neural networks keep surprising even the experts.
37:23ENFrom Chat to Always-On Agents: OpenAI's Tibo Sottiaux on Dots, Open Ecosystems and What Comes NextModeration: Lenny RachitskyThe head of ChatGPT and Codex, speaking hours after a DevDay launch of more than 20 products, explains the vision for a personal agent that works around the clock.
1:26:42ENInside Block's AI-Native Bet: Goose, Functional Orgs and Throwing Code AwayGast: Dhanji R. Prasanna · Moderation: Lenny RachitskyBlock CTO Dhanji Prasanna explains how a reorg, an open-source agent and a learning-first culture made the company unusually AI-forward.
57:11ENFrom Artifact to Organism: Microsoft's Asha Sharma on Products That Learn and an Agentic SocietyGast: Asha Sharma · Moderation: Lenny RachitskyMicrosoft's AI platform product chief explains why products are becoming living systems tuned by post-training, why interfaces are shifting toward code and composability, and how agents may reshape the org chart.
44:53ENLegora's CEO on Building Legal AI That Survives the Next Model ReleaseModeration: Jacob EffronMax explains how Legora turns fast-moving model capabilities into end-to-end legal work, enterprise adoption, and a durable product strategy.
33:31ENOpen Source Catches Up, Regulation Can Wait: Sarah Guo and Elad Gil Answer Listener QuestionsModeration: Sarah Guo, Elad GilTwo AI investors cover open-source models, autonomous agents, whether to regulate AI, where startups can win, and why healthcare innovation is so hard.
45:00ENAgents Everywhere: OpenAI's Blueprint for Tool Use, Evals, and Computer-Use InfrastructureModeration: Jacob EffronOpenAI's API platform team explains how agents are moving from deterministic workflows to reasoning-driven tool use, and what developers still lack.
54:52ENCoding Agents Are Breaking Containment: The 2026 AI Stack, the Coding Wars, and the Next FrontierModeration: Jacob EffronJacob Effron and Swyx map the state of AI engineering, from agent harnesses and infrastructure churn to coding-market economics, open models, dark factories, and world models.
29:09ENPlan in 90-Day Windows: How OpenAI's Product Leaders Ship Fast Without Losing the PlotModeration: Lenny RachitskyOpenAI's Tara Seshan and Nan Yu tell Claire Vo how they ship imperfect features, design agents people can follow, work with research, and think about 2027.









