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57:25ENFrom RAG to Reasoning: Why the Future of AI Is a System, Not a ModelModeration: Jacob EffronDouwe Kiela explains what OpenAI's o1 reveals about test-time compute, why enterprise AI must be specialized, and where post-training and evaluations are heading.
1:03:21ENBring the Insight: How a Young Product Leader Earns Trust at AsanaGast: Paige Costello · Moderation: Lenny RachitskyAsana's Paige Costello on planning, the Double Diamond process, coaching PMs, and what holds new product managers back.
1:18:28ENCuriosity Loops: Ada Chen Rekhi's Method for Better Decisions and a Career You Won't RegretGast: Ada Chen Rekhi · Moderation: Lenny RachitskyAn executive coach and Notejoy co-founder on structured advice-gathering, values exercises, explore-and-exploit careers, coaching and co-founding with a spouse.
50:23ENOpenAI’s Platform Bet: Where AI Value Accrues, Why Open Source Trails, and When Superintelligence ArrivesModeration: Jacob EffronPeter Welinder explains OpenAI’s platform strategy, the case for proprietary frontier models over open source, the enterprise hallucination problem, and his speculative timeline for AGI and superintelligence.
1:21:17ENScaling People: Claire Hughes Johnson on Building the Company Behind the ProductGast: Claire Hughes Johnson · Moderation: Lenny RachitskyStripe's former COO explains why operating structure, self-awareness and plain-spoken management matter as much as product-market fit.
13:58ENDeep Reinforcement Learning, Explained by the Researcher Behind AlphaGoModeration: Lex FridmanDavid Silver of DeepMind walks through what reinforcement learning is, how its building blocks fit together, and why deep neural networks keep surprising even the experts.
1:21:57ENBehind the Wheel: How Uber's Product Chief Dogfoods His Way to Better ProductsModeration: Lenny RachitskySachin Kansal on extreme dogfooding, shipping fast, Uber's hybrid autonomy strategy and making gut calls against the data.
1:11:26ENManage Your Career Like a Product: Deb Liu on Resilience, Introversion and Big SwingsGast: Deb Liu · Moderation: Lenny RachitskyThe former Facebook VP and current Ancestry CEO explains how to keep learning, bounce back from failure, build new businesses inside large companies, and plan a career with intention.
1:21:08ENThe Opposite of Play Is Fear: How Jira's Head of Product Builds Safe, Fast-Moving TeamsGast: Megan Cook · Moderation: Lenny RachitskyMegan Cook of Atlassian on psychological safety, remote work habits, winning buy-in, and how a 12,000-person company keeps launching new products.
57:55ENFrom Q-Tables to AlphaGo Zero: A Self-Driving Car Lecture on Deep Reinforcement LearningModeration: Lex FridmanLex Fridman's MIT 6.S094 lecture walks from the AI pipeline and Q-learning to deep Q-networks, AlphaGo Zero and the DeepTraffic competition.
37:23ENFrom Chat to Always-On Agents: OpenAI's Tibo Sottiaux on Dots, Open Ecosystems and What Comes NextModeration: Lenny RachitskyThe head of ChatGPT and Codex, speaking hours after a DevDay launch of more than 20 products, explains the vision for a personal agent that works around the clock.
1:35:27ENSacred Cows Are Your Roadmap: Kayvon Beykpour on Reviving Twitter's Product CultureGast: Kayvon Beykpour · Moderation: Lenny RachitskyThe former head of product at Twitter on meeting Elon Musk, being fired during paternity leave, shipping through a risk-averse culture, and the lessons of Periscope.
1:00:25ENCan Machines Think? A Guided Tour of Turing's Test, Its Critics and Its SuccessorsGast: Turing Test · Moderation: Lex FridmanLex Fridman walks through Alan Turing's 1950 paper, the objections to it, and the benchmarks that have tried to replace or extend the imitation game.
51:55ENThe Search Engine Under AI Apps: Why Bigger Context Windows Aren't EnoughModeration: Jacob EffronTurbopuffer CEO Simon on object-storage databases, vector-search trade-offs, and the AI features that will become SaaS table stakes.
1:11:58ENDare to Be Dull: A Stanford Communication Teacher's Playbook for Calmer, Sharper SpeakingGast: Matt Abrahams · Moderation: Lenny RachitskyMatt Abrahams shares practical ways to calm speaking anxiety and structure on-the-spot talk, from small talk and feedback to toasts, Q&A and apologies.
17:35ENHands Off the Wheel in San Diego: A Comma Two Demo Drive and a Tour of comma.ai's Hardware ShopModeration: Lex FridmanAfter their podcast conversation, George Hotz takes Lex Fridman on an openpilot drive and then through the comma.ai offices, dashboards, assembly line and compute cluster.
1:19:24ENLoops, Local Maxima and Ambition: Anish Acharya on How AI Rewires Companies and Consumer ProductsModeration: Lenny Rachitskya16z's Anish Acharya argues that companies will become stacks of AI loops guided by human intuition, and that the biggest consumer prize is a loop that makes people happier.
1:42:28ENJournalists Don't Care About You: A Magazine Editor's Field Guide to Getting PressGast: Jason Feifer · Moderation: Lenny RachitskyEntrepreneur editor-in-chief Jason Feifer explains how to prepare, pick the right writer, and pitch a story that an editor will actually say yes to.
1:03:27ENFind the Cultural Erogenous Zone: A Comms Playbook for Making Ideas SpreadGast: Lulu Cheng Meservey · Moderation: Lenny RachitskyLulu Cheng Meservey, the former Substack comms head, explains how underdog startups can build their own audiences, take smarter risks and shape messages people want to repeat.
1:13:22ENThe Second 90%: What It Really Takes to Put Deep Learning on a Driverless CarModeration: Lex FridmanWaymo's Sacha Arnoud walks MIT students through Waymo's history, its perception stack, and the industrial-scale labeling, compute and testing behind it.
19:13ENThe Higgs Was the Missing Puzzle Piece. The Real Mystery Is Why It Exists at AllModeration: Lex FridmanParticle physicist Harry Cliff explains why finding the Higgs confirmed the obvious, why its tuned value is so troubling, and why the search for a deeper theory is stuck.
1:32:06ENHow monday.com Turned a Competitor's Surprise Launch into a New Operating SystemModeration: Lenny RachitskyChief Product and Technology Officer Daniel Lereya explains how impossible goals, radical transparency and timeboxed deadlines took monday.com past $1 billion in ARR.
1:31:50ENZero to $80M in Six Months: How a Solo Founder Bootstrapped Base44 to a Wix ExitModeration: Lenny RachitskyMaor Shlomo explains how he built and grew the AI app builder Base44 without outside funding, the stack and habits that let one person compete with well-funded rivals, and how the Wix acquisition came together.
40:25ENA Language That Knows the World: Stephen Wolfram on Computable KnowledgeModeration: Lex FridmanIn this clip from the Lex Fridman Podcast, Stephen Wolfram explains what makes the Wolfram Language different from ordinary programming languages and how it grew into a computable knowledge base, from Wolfram Alpha to computational contracts.
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