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12:52ENRoger Penrose on a Universe That Restarts: When the Far Future Becomes the Next Big BangGast: Roger Penrose · Moderation: Lex FridmanPenrose explains conformal cyclic cosmology, in which the remote future of one cosmic eon is mathematically the same as the Big Bang of the next.
1:13:36ENAsk for What You Want: Kenneth Berger on Integrity, Hearing No, and Getting Fired from Slack Three TimesGast: Kenneth Berger · Moderation: Lenny RachitskyThe first PM at Slack turned executive coach lays out a three-step practice for naming your desires, asking for them, and accepting whatever answer comes back.
1:38:00ENRun Toward the Pain: Ben Horowitz on Hesitation, Confidence and Leading a Company Through the AbyssGast: Ben Horowitz · Moderation: Lenny RachitskyThe Andreessen Horowitz co-founder talks about the psychology of being a CEO, what product managers get wrong about leadership, whether AI is a bubble, and why the US must stay in the AI race.
22:08ENHeavy, Patient, Relentless: What a Day on the Mats With Khabib Nurmagomedov Feels LikeModeration: Lex FridmanLex Fridman trains with Khabib Nurmagomedov and his team, then hears how Khabib thinks about pressure, endurance and never stopping.
14:47ENBuild Your Own Types: What Bjarne Stroustrup Learned from Simula, Fortran and LispGast: Bjarne Stroustrup · Moderation: Lex FridmanThe creator of C++ traces how Simula's user-defined types shaped his language, and why he builds for constrained, long-lived systems.
2:04:21EN"AI Doctors Are Here": A Father's Account of Fighting His Son's Burkitt Leukemia With GPT-5 Pro and Gemini 3Moderation: Nathan LabenzNathan Labenz recounts the first three weeks of his 6-year-old son's cancer diagnosis and how frontier models served as second opinions, bedside co-pilots and relapse planners.
24:08ENIntelligence Is Not Just Prediction: David Ferrucci on Explanation, Persuasion and Shared MeaningGast: David Ferrucci · Moderation: Lex FridmanThe lead of IBM's Watson team argues that predicting well is only half of intelligence, and that being understood by others is the other half.
22:03ENRunning the Drake Equation: Lex Fridman's Estimate of Alien Civilizations, From 0.7 in the Milky Way to Trillions in the UniverseModeration: Lex FridmanLex Fridman walks through each parameter of the Drake equation with optimistic, pessimistic and personal estimates, then argues the real lesson is how little we understand about intelligence and communication.
1:26:42ENInside Block's AI-Native Bet: Goose, Functional Orgs and Throwing Code AwayGast: Dhanji R. Prasanna · Moderation: Lenny RachitskyBlock CTO Dhanji Prasanna explains how a reorg, an open-source agent and a learning-first culture made the company unusually AI-forward.
1:12:12ENModels Are Grown, Not Built: What Anthropic's Interpretability Research Sees Inside ClaudeModeration: Lenny RachitskyAnthropic researcher Emmanuel Ameisen explains how studying a language model's intermediate computations reveals concepts, plans and surprising quirks, and why that matters for alignment.
57:11ENFrom Artifact to Organism: Microsoft's Asha Sharma on Products That Learn and an Agentic SocietyGast: Asha Sharma · Moderation: Lenny RachitskyMicrosoft's AI platform product chief explains why products are becoming living systems tuned by post-training, why interfaces are shifting toward code and composability, and how agents may reshape the org chart.
1:32:41ENYou Can Patch a Bug but You Can't Patch a Brain: Why AI Guardrails FailModeration: Lenny RachitskyHackAPrompt's Sander Schulhoff explains why prompt injection and jailbreaking remain unsolved, why the guardrail industry is selling false comfort, and what organizations can do instead.
1:42:57ENFive Seconds, Real Stakes: Matthew Dicks on How to Tell Stories People RememberGast: Matthew Dicks · Moderation: Lenny RachitskyThe 59-time Moth Story Slam winner and author of Storyworthy explains the single-moment structure of good stories, how to use them at work, and how to calm stage nerves.
40:58ENBuilding AI Products When the Ground Keeps MovingModeration: Lenny RachitskyOpenAI's Kevin Weil and Anthropic's Mike Krieger discuss how AI product management differs from traditional software, from evals and enterprise buyers to computer use, reasoning models, and proactive agents.
1:12:19ENThe Three W's: A Practical Framework for Growing as a Product ManagerGast: Vikrama Dhiman · Moderation: Lenny RachitskyGojek's head of product Vikrama Dhiman explains what separates fast-rising PMs from stalled ones, and how to move into product from another discipline.
23:11ENNick Bostrom on Superintelligence: Why the Upside Deserves as Much Attention as the RiskGast: Nick Bostrom · Moderation: Lex FridmanIn a clip from the Lex Fridman Podcast, Oxford philosopher Nick Bostrom defines superintelligence, discusses intelligence explosions, and sketches what a good AGI future might look like.
22:17ENWhat Is Real? Lee Smolin on Realism, Science and StorytellingModeration: Lex FridmanThe theoretical physicist explains why he believes in a world independent of our perception, why he doubts there is a single scientific method, and where realism meets quantum mechanics.
1:27:51ENOptimism, Laziness and "What If": Lessons from the Man Behind Google DocsGast: Sam Schillace · Moderation: Lenny RachitskySam Schillace, who created Writely (later Google Docs) and now helps lead AI work at Microsoft, on disruptive ideas, user laziness, failing on purpose, and where software is headed.
1:12:18ENThe Lego Inside Notion: Ivan Zhao on Lost Years, Small Teams, and Horizontal BetsModeration: Lenny RachitskyIvan Zhao explains how Notion survived its lost years, stayed lean, corrected a non-Lego product detour, and built a horizontal platform now being reshaped by AI.
1:35:10ENTen Growth Tactics That Never Work, According to Elena VernaGast: Elena Verna · Moderation: Lenny RachitskyGrowth leader Elena Verna runs through the growth plays she sees companies waste money on, the three frameworks she trusts instead, and her case for career optionality.
1:42:11ENTwenty Agents, 1.2 Humans: Inside SaaStr's AI-Run Sales TeamModeration: Lenny RachitskyJason Lemkin explains how SaaStr replaced a ten-person go-to-market team with AI agents, what it took to train them, and who survives the shift.
1:09:38ENRyan Hoover on Experiments, Launches and the Mask Every Founder WearsGast: Ryan Hoover · Moderation: Lenny RachitskyThe Product Hunt founder and Weekend Fund investor talks about starting small, raising money for a reason, launching well, his own regrets and how he now invests.
1:22:51ENCold DMs, Dinner-Party Communities, and the Case Against Jobs-to-Be-DoneModeration: Lenny RachitskyAarthi Ramamurthy and Sriram Krishnan on techno-optimism, relationship-driven careers, content creation, imposter syndrome, executive reviews, and why real products are trade-offs.
1:01:13ENNLX Is the New UX: Microsoft's Aparna Chennapragada on Designing for AgentsGast: Aparna Chennapragada · Moderation: Lenny RachitskyMicrosoft's chief product officer explains how she is building AI products a year ahead of the market, why conversation is a designable interface, and what stays the same for product builders.
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