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33:31ENOpen Source Catches Up, Regulation Can Wait: Sarah Guo and Elad Gil Answer Listener QuestionsModeration: Sarah Guo, Elad GilTwo AI investors cover open-source models, autonomous agents, whether to regulate AI, where startups can win, and why healthcare innovation is so hard.
1:19:39ENEngineers Become Sorcerers: OpenAI's Sherwin Wu on the Next 12 to 24 MonthsModeration: Lenny RachitskyThe head of engineering for OpenAI's API and developer platform describes life with Codex, how management is changing, and why builders should aim for where the models are going.
45:00ENAgents Everywhere: OpenAI's Blueprint for Tool Use, Evals, and Computer-Use InfrastructureModeration: Jacob EffronOpenAI's API platform team explains how agents are moving from deterministic workflows to reasoning-driven tool use, and what developers still lack.
1:31:56ENPerfect Is Creepy: What a Child Psychologist Knows About Leading Difficult AdultsModeration: Lenny RachitskyDr. Becky Kennedy explains how the principles she uses to raise resilient kids apply to managers, teams and colleagues.
1:04:06ENBuild the Model, Then Garden the Marketplace: Dan Hockenmaier on Growth Models and Marketplace StrategyGast: Dan Hockenmaier · Moderation: Lenny RachitskyFaire's head of strategy and analytics explains how to build a growth model, which marketplace metrics matter, and why marketplaces demand a light touch.
54:52ENCoding Agents Are Breaking Containment: The 2026 AI Stack, the Coding Wars, and the Next FrontierModeration: Jacob EffronJacob Effron and Swyx map the state of AI engineering, from agent harnesses and infrastructure churn to coding-market economics, open models, dark factories, and world models.
1:28:38ENBuild for Feelings, Not Graphs: Inside The Browser Company's Product PhilosophyGast: Josh Miller · Moderation: Lenny RachitskyJosh Miller, CEO of The Browser Company, explains how Arc is built around emotions, values, a tiny-but-unusual team and a bet on the internet as the next computer.
10:39ENStatistics as Decision-Making: Michael I. Jordan on Bayesians, Frequentists and the Ideas Between ThemModeration: Lex FridmanBerkeley's Michael I. Jordan explains where statistics came from, why it is really about decisions, and how empirical Bayes and false discovery rate bridge two rival philosophies.
11:29ENWhy Tesla AI Day Was the Most Impressive Real-World AI Effort Lex Fridman Has SeenModeration: Lex FridmanLex Fridman walks through the neural network, data annotation, Dojo and Tesla Bot announcements and what they say about solving real-world robotics.
1:38:33ENPrice Before Product: Madhavan Ramanujam's Masterclass on Monetizing InnovationGast: Madhavan Ramanujam · Moderation: Lenny RachitskyThe author of Monetizing Innovation walks product teams through willingness-to-pay research, segmentation, pricing models, benefit messaging and behavioral pricing.
1:06:22ENPerplexity's Bet: Search Becomes Answers, and Answers Become a BusinessModeration: Jacob EffronThe Perplexity CEO explains how a consumer AI search product is built, sequenced, and defended against Google.
1:01:12ENThe Failure Dividend: What Leaders from Airbnb, Google, Pets.com, Quibi, Duolingo, and Toast Learned from Their Worst MomentsModeration: Lenny RachitskyA compilation of product leaders' most searing failures—and the operating lessons they extracted from them.
52:28ENRay Kurzweil on Hierarchies, the Neocortex and Merging with AIGast: Ray Kurzweil · Moderation: Lex FridmanIn an MIT AGI course lecture, Kurzweil connects the history of neural networks to his hierarchical theory of the neocortex, language understanding at Google, longevity, jobs and existential risk.
1:19:32ENProduct Ops Is the Operating System Your Product Team Is MissingModeration: Lenny RachitskyMelissa Perri and Denise Tilles explain how product operations frees product managers from busywork, improves decision speed, and scales product organizations without adding unnecessary overhead.
48:18ENStop Writing Solutions as Opportunities: Teresa Torres on Opportunity Solution Trees and Weekly Customer InterviewsGast: Teresa Torres · Moderation: Lenny RachitskyThe author of Continuous Discovery Habits explains how to structure a messy product problem, collect customer stories every week, and make better bets with small amounts of data.
2:03:00ENBan Superintelligence or Build the Rules as We Go? Max Tegmark and Dean Ball Clash Over a Precautionary AI RegimeModeration: Nathan LabenzIn a Doom Debates crossover, the Future of Life Institute's Max Tegmark and former White House adviser Dean Ball argue over whether superintelligence should be prohibited until it is provably controllable.
1:25:15ENProduct Management Theater and the Road Out: Marty Cagan on TRANSFORMEDGast: Marty Cagan · Moderation: Lenny RachitskyThe SVPG founder explains why many PM roles are really project management, how AI raises the stakes, and how companies can move from feature teams to empowered product teams.
1:00:15ENCircuit Search, Hindsight and Self-Play: Ilya Sutskever's Case for Where Learning Is GoingGast: Ilya Sutskever · Moderation: Lex FridmanIn an MIT AGI lecture, OpenAI's co-founder explains why deep learning works, then walks through meta-learning, hindsight experience replay, sim-to-real transfer, self-play and learning goals from human feedback.
1:36:53ENIdeology, Restraint and the Core: Peter Sellis on Building Product Teams That WinModeration: Lenny RachitskySnapchat's first PM and former Discord head of product speaks candidly about team design, why the median PM is weak, and where consumer growth really comes from.
1:16:05ENThe Founder Is the Product: A Tactical Guide to Founder-Led SalesModeration: Lenny RachitskyJen Abel walks through outbound messaging, first calls, co-authored scoping, procurement, and closing for early-stage founders.
20:16ENProduct Management Is Dead. What Comes Next Is an AI-Powered Triple ThreatModeration: Lenny RachitskyClaire argues that AI is collapsing the PM craft and replacing the product triad with multi-skilled leaders backed by agents, tools and a culture of automation.
1:46:04ENWhy Growth Stalls: Jason Cohen's Ordered Checklist for Getting UnstuckGast: Jason Cohen · Moderation: Lenny RachitskySerial founder Jason Cohen walks through the questions he asks, in order, when a product's growth slows, from churn and pricing to net revenue retention, saturated channels and whether you need to grow at all.
18:24ENFive Lessons from a 91-Year-Old Grandmother: Lex Fridman Remembers the Woman Who Shaped HimModeration: Lex FridmanLex Fridman uses his microphone to honor his late grandmother, recounting what she taught him about toughness, strength, quiet thought, self-belief and love.
11:26ENThe Cookie Your Brain Bakes: Joscha Bach on Happiness, Cells and the Meaning of GodModeration: Lex FridmanIn a short clip, Joscha Bach moves from why happiness is not the point to the cell as a cosmic probe and a naturalistic reading of God as civilization.
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