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1:22:04ENElevenLabs CEO Mati Staniszewski on Voice AI, Growth and Building from EuropeGast: Mati Staniszewski · Moderation: Harry StebbingsStaniszewski discusses the company’s origins in dubbing, its financing and reported ARR, and the challenges of scaling voice products.
44:49ENHow OpenEvidence Became the Clinical OS for 40% of U.S. DoctorsModeration: Sarah Guo, Elad GilFounder Daniel Nadler tells No Priors how a free search tool for physicians, not an answer engine for patients, took high-stakes clinical knowledge in 18 months.
1:12:58ENChris Lattner on Mojo and the Search for Portable GPU PerformanceYaron Minsky, Chris Lattner · Jane StreetRon Minsky and Chris Lattner discuss the language and compiler design behind Modular’s effort to make accelerator programming both portable and fast.
3:36:25ENT. rex Was an Orca on Land. Almost Nothing Else Matches the Movies.Gast: Dave Hone · Moderation: Lex FridmanPaleontologist Dave Hone walks Lex Fridman through T. rex size, bone-crushing anatomy, hunting, extinction, and what Jurassic Park still gets wrong.
1:14:39ENNick Frosst on Cohere’s Enterprise AI Strategy and the Limits of HypeGast: Nick Frosst · Moderation: Harry StebbingsThe Cohere co-founder discusses data, benchmarks, workplace automation and why he challenges popular claims about AGI.
1:50:28ENThe 87-Kilobyte Program Two Billion People Open Every MonthGast: Dave Plummer · Moderation: Lex FridmanDave Plummer talks Lex Fridman through Task Manager, old-school Microsoft, and how an autistic mind actually works.
40:54ENSeventeen Years of Flat Power, and a Plan to Bring the Factories HomeModeration: Sarah Guo, Elad GilJacob Helberg, the under secretary of state designate for economic growth, energy, and the environment, argues that nuclear power and AI productivity—not cheap labor—are how America reshore its supply chain.
1:01:23ENWill Crichton on Making Rust More UnderstandableWill Crichton · Brown UniversityOwnership visualizations, interactive trait diagnostics and program slicing illustrate an evidence-based approach to developer tools.
20:05ENAI News: Macrohard, Comet Plus and the Debate Over AI WelfareMatthew Berman, Dara Khosrowshahi · Forward FutureMatthew Berman reviews August 2025 AI news, from generative worlds and publisher payments to robotics, Intel and enterprise AI results.
1:23:11ENBessemer’s Byron Deeter on AI Growth, Venture Scale and LiquidityGast: Byron Deeter · Moderation: Harry StebbingsDeeter discusses AI software economics, follow-on investments and the trade-offs facing venture firms and their limited partners.
10:26:31ENThe War on Terror's Only Gift Was Better Luke Skywalker HandsGast: Scott Horton · Moderation: Lex FridmanScott Horton walks Lex Fridman through fifty years of U.S. wars, from Vietnam Syndrome to Ukraine, and argues the machinery never stops because it is not supposed to.
42:12ENHire the AI First: Andrew Ng on Agentic Workflows and the Scarcity of JudgmentModeration: Sarah Guo, Elad GilOn No Priors, Andrew Ng argues that agentic AI has made software cheap and fast, which moves the bottleneck to product judgment, error analysis, and the instinct to try an AI before adding headcount.
1:14:08ENLovable CEO Anton Osika on AI App Building, Economics and SecurityGast: Anton Osika · Moderation: Harry StebbingsOsika discusses Lovable’s reported growth, model costs and product strategy while Stebbings challenges its defensibility and security.
1:09:11ZH广密谈大模型分化、AI 产品与创业窗口Gast: 广密 · Moderation: 张小珺广密复盘模型公司的战略分化、ChatGPT 的消费品牌壁垒,以及 Claude Code 等产品带来的新机会。他认为 AI 创业窗口正在缩短,但产品体验、团队判断和非共识创新仍能打开空间。
13:30ENHow AlphaGeometry Combines Logical Proof with Creative ConstructionAleph0Aleph0 explains how a symbolic geometry solver gets surprisingly far without AI, and how a language model supplies the auxiliary constructions that take it to Olympiad level.
47:18ENThe Analyst Tracking 200 GPU Clouds Breaks Nvidia Into a Three-Headed DragonModeration: Sarah Guo, Elad GilSemiAnalysis founder Dylan Patel on OpenAI’s open-weight model, a coming neocloud wipeout, and why a chip startup has to beat Nvidia on hardware, networking, and software at once.
1:49:29ENChina Is Not Run by One Person. It Is a Mayor EconomyGast: Keyu Jin · Moderation: Lex FridmanEconomist Keyu Jin on local GDP races, DeepSeek, tariffs, Jack Ma, and why Western collapse forecasts keep missing the country they describe.
1:22:51ENMartin Mignot on Index Ventures, Revolut and Investing in FoundersGast: Martin Mignot · Moderation: Harry StebbingsThe Index Ventures partner explains how he evaluates early-stage companies, manages concentrated returns and learns from missed opportunities.
45:17ENA Click From OpenAI Is 750 Times Harder Than From Google a Decade AgoModeration: Sarah Guo, Elad GilCloudflare CEO Matthew Prince on Content Independence Day, why traffic is a broken proxy for value, and how to price the holes in the models.
40:32ENMark Chen on GPT-5, Synthetic Data and the Future of AI ResearchMatthew Berman, Mark Chen · Forward FutureOpenAI’s head of research discusses training, agents, open-weight releases and evaluation with Matthew Berman in August 2025.
1:30:36ENMiles Dieffenbach on Endowment Investing, Venture Returns and LiquidityGast: Miles Dieffenbach · Moderation: Harry StebbingsThe Carnegie Mellon allocator explains how he compares venture funds with public markets and evaluates fund size, fees and private marks.
36:48ENThe Weekend DeepSeek Dropped, the White House CalledModeration: Sarah Guo, Elad GilSriram Krishnan walks No Priors through America’s 28-page AI Action Plan, a token-share definition of winning, and why the lead over China is too small to take for granted.
4:30:02ENGenghis Khan Never Fought a Battle He Thought He Could LoseGast: Jack Weatherford · Moderation: Lex FridmanAnthropologist Jack Weatherford tells Lex Fridman how an abandoned boy on the Mongolian steppe built the largest contiguous empire in history—and why conquest is only part of the story.
1:16:25ENMartin Casado on AI Models, Open Technology and Venture CompetitionGast: Martin Casado · Moderation: Harry StebbingsThe Andreessen Horowitz partner discusses coding tools, open-model policy, labor disruption and how his firm evaluates investments.
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