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1:30:36ENMiles Dieffenbach on Endowment Investing, Venture Returns and LiquidityGast: Miles Dieffenbach · Moderation: Harry StebbingsThe Carnegie Mellon allocator explains how he compares venture funds with public markets and evaluates fund size, fees and private marks.
36:48ENThe Weekend DeepSeek Dropped, the White House CalledModeration: Sarah Guo, Elad GilSriram Krishnan walks No Priors through America’s 28-page AI Action Plan, a token-share definition of winning, and why the lead over China is too small to take for granted.
4:30:02ENGenghis Khan Never Fought a Battle He Thought He Could LoseGast: Jack Weatherford · Moderation: Lex FridmanAnthropologist Jack Weatherford tells Lex Fridman how an abandoned boy on the Mongolian steppe built the largest contiguous empire in history—and why conquest is only part of the story.
1:16:25ENMartin Casado on AI Models, Open Technology and Venture CompetitionGast: Martin Casado · Moderation: Harry StebbingsThe Andreessen Horowitz partner discusses coding tools, open-model policy, labor disruption and how his firm evaluates investments.
58:47ENDaniel Pontecorvo on Cooling Trading Infrastructure and WorkspacesYaron Minsky, Daniel Pontecorvo · Jane StreetFrom dense GPU racks to movable desks, Jane Street’s physical engineering team designs around heat, power, failure and human comfort.
1:27:41ENRon Minsky on the Saga of Multicore OCaml at Jane StreetRon Minsky · Jane StreetA production migration exposed garbage-collector regressions, led to a new pacing design, and illustrated the difficulty of turning research into reliable infrastructure.
32:59ENA Hundred People, a Billion in Revenue, and Zero Venture MoneyModeration: Sarah Guo, Elad GilSurge AI founder Edwin Chen on why quality human data is a poetry problem, not a bounding-box problem, and why leaderboards keep training models to write clickbait.
2:28:14ENNature Has Structure: Demis Hassabis on Learnable Reality and AGIGast: Demis Hassabis · Moderation: Lex FridmanThe Google DeepMind CEO argues that evolution-shaped systems can be modeled by classical learning, and that interactive world models sit on the path to AGI.
1:07:41ENEdwin Chen on Building Surge and the Data Behind AI ModelsGast: Edwin Chen · Moderation: Harry StebbingsThe Surge founder discusses a bootstrapped business, training-data quality and the limits he sees in AI benchmarks and synthetic data.
47:05ENLogan Kilpatrick on AI Developers, Interfaces, and the Future of ModelsMatthew Berman, Logan Kilpatrick · Forward FutureIn a July 2025 conversation, Google’s Logan Kilpatrick discusses Windsurf, agent interfaces, coding skills, Veo, and the shifting boundary between models and application scaffolding.
51:06ENScott Wu on Cognition's Windsurf Deal and the Future of AI CodingGast: Scott Wu · Moderation: Harry StebbingsThe Cognition CEO explains the fast-moving acquisition, the role of AI agents in engineering, and his predictions for software development.
1:02:54ENEnterprise Coding Tools Flipped the 80/20. Reflection AI Built the Other HalfModeration: Sarah Guo, Elad GilFormer Gemini reward-model lead Misha Laskin on Asimov, why comprehension beats generation, and why there is no such thing as generalization—only pulling the test distribution into train.
1:02:16ENVlad Tenev on Robinhood, Tokenized Assets and Building Financial ProductsGast: Vlad Tenev · Moderation: Harry StebbingsThe Robinhood CEO discusses active traders, AI adoption, private-market tokens and the company’s plans for broader financial services.
6:08:48ENNobody Serious Believes Cookie Banners Help AnyoneGast: DHH · Moderation: Lex FridmanLex Fridman talks with David Heinemeier Hansson for six hours about Ruby, Rails, AI, leaving the cloud, Apple's App Store, and why a small company can still refuse other people's money.
44:44EN$1 of R&D, 35x the return: why Parker Conrad says platforms beat point solutionsModeration: Sarah Guo, Elad GilThe Rippling CEO on Zenefits, founder psychology, and why shared underlying capabilities—not narrow focus—win in enterprise software.
1:14:02ENScott Galloway on Wealth, Work, Relationships and PurposeGast: Scott Galloway · Moderation: Harry StebbingsThe professor and entrepreneur discusses market power, generational inequality and the personal cost of tying identity to money.
49:27ENFrom 0.1% to 20%: Chai-2 Turns Antibody Design Into Prompt EngineeringModeration: Sarah Guo, Elad GilChai Discovery co-founders Joshua Meier and Jack Dent tell Sarah Guo how a generative model now designs antibodies that bind on the first 24-well plate.
1:09ENA Discussion of GPT-4.5’s Scaling and TrainingA speaker offers an assessment of GPT-4.5’s cost, speed and alleged training challenges.
2:53ENJane Street Interns on Projects, Mentorship and LearningDylan · Jane StreetFormer interns and staff describe the learning, open-ended projects and relationships that shaped their internship experience.
1:04:33ENPhilipp Freise on KKR’s European Investing and Private-Market LiquidityGast: Philipp Freise · Moderation: Harry StebbingsThe KKR investor discusses deployment discipline, AI, European capital markets and broader access to private investments.
42:09ENAlphaEvolve found algorithms humans missed for 50 years — then sped up Gemini 23%Moderation: Sarah Guo, Elad GilGoogle DeepMind’s Pushmeet Kohli and Matej Balog tell No Priors how an evolutionary coding agent searches algorithm space the way AlphaGo searched Go.
1:24:26ENJohannes Reck on Building GetYourGuide Through Growth and CrisisGast: Johannes Reck · Moderation: Harry StebbingsThe travel marketplace founder discusses early pivots, fundraising mistakes, pandemic survival and the challenge of scaling in Europe.
0:57ENSundar Pichai on Preparing for AI in Knowledge WorkMatthew Berman, Sundar Pichai · Forward FutureIn a short interview clip, Google's CEO suggests learning to use AI as an everyday assistant while work changes.
1:32:16ZH王忻谈奔驰中国研发:在转型中重划豪华与安全Gast: 王忻 · Moderation: 张小珺奔驰中国研发负责人王忻回顾中国汽车产业二十年的技术周期,也讲述中国团队如何从测试支持走向产品研发。面对智能化竞争,他认为速度、数据和本地化必须建立在安全与用户体验之上。
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