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1:06:40ENJanie Lee on Product Judgment, Hiring and Enterprise ExpansionGast: Janie Lee · Moderation: Harry StebbingsThe Loom product leader discusses customer problems, clear writing, product reviews and the shift from self-serve adoption to enterprise sales.
2:51:58ENSara Walker: Life Is Huge in Time, Not in SpaceGast: Sara Walker · Moderation: Lex FridmanThe astrobiologist tells Lex Fridman why textbook definitions of life fail, how assembly theory measures complexity, and why aliens might disappear into their own causal structure.
1:06:04ENAlexandr Wang on AI Data, Model Development and Building ScaleGast: Alexandr Wang · Moderation: Harry StebbingsScale’s founder discusses his data-bottleneck thesis, enterprise adoption, AI security and the challenges of growing a team.
26:00ENWhy a Zapier founder thinks AGI research has been stalled for four yearsModeration: Sarah Guo, Elad GilMike Knoop and François Chollet put more than a million dollars on beating ARC-AGI, the eval they say actually measures general intelligence.
1:25:42ENReid Hoffman on AI Models, Inflection, Governance and Technology’s Social ImpactGast: Reid Hoffman · Moderation: Harry StebbingsHoffman discusses the Microsoft–Inflection arrangement, AI competition and regulation, and his political views in a time-specific 2024 interview.
53:43ENAshley Kelly on Hiring, Onboarding and Scaling Sales DevelopmentGast: Ashley Kelly · Moderation: Harry StebbingsRippling’s sales-development leader discusses SDR roles, compensation, coaching and the practical challenges of growing a global team.
36:20ENA Hundred Million Tokens in Context Would Cost $10 Million. Tengyu Ma Runs the RAG MathModeration: Sarah Guo, Elad GilThe Stanford professor and Voyage AI founder argues that retrieval, not a giant context window, is how enterprises should manage private knowledge.
2:19:08ENHe Asked to Vanish from the Poster. The Second Time, Hollywood Did It for HimGast: Kevin Spacey · Moderation: Lex FridmanKevin Spacey talks with Lex Fridman about Se7en, American Beauty, House of Cards, the 2017 allegations, and a father whose study held a Nazi flag.
1:03:12ENAravind Srinivas on Reasoning, Model Economics and Building PerplexityGast: Aravind Srinivas · Moderation: Harry StebbingsThe Perplexity co-founder discusses AI scaling, foundation-model competition, advertising and the challenges of building a search product.
1:20:50ENJason Lemkin on SaaS Valuations, Private Equity and the Liquidity ProblemGast: Jason Lemkin · Moderation: Harry StebbingsThe SaaStr founder discusses slowing software growth, AI budgets, venture returns and why the next exit may be harder to find.
2:15:39ENRoman Yampolskiy Puts Superintelligent Ruin at 99.99 PercentGast: Roman Yampolskiy · Moderation: Lex FridmanThe AI safety researcher tells Lex Fridman that controlling AGI is as impossible as a perpetual motion machine, and that tests, open source, and regulation cannot close the gap.
56:35ENMatt Lerner on Finding Growth Levers and Hiring Teams That LearnGast: Matt Lerner · Moderation: Harry StebbingsThe former PayPal growth leader explains how startups can discover their strongest channels, choose customer-centered metrics and hire for curiosity.
24:06ENOpenAI’s 2023 Board Crisis: Helen Toner’s Account and the Governance DebateMatthew Berman, Helen Toner · Forward FutureMatthew Berman examines a former director’s allegations, a subsequent review and competing views on AI safety oversight.
1:15:53ENMike Schroepfer on Leadership, Climate Technology and Clean EnergyGast: Mike Schroepfer · Moderation: Harry StebbingsThe former Meta CTO explains how leaders align teams and how his climate investment firm evaluates technology, financing and market risk.
1:24:54ENJason Lemkin on SaaS Investing, Churn and Seed ValuationsGast: Jason Lemkin · Moderation: Harry StebbingsThe SaaStr founder revisits successful and disappointing deals, explains his diligence process and assesses the economics of seed investing.
3:10:49ENMemory Is Not a Replay: Charan Ranganath on Forgetting, Imagination, and False MemoriesGast: Charan Ranganath · Moderation: Lex FridmanA UC Davis neuroscientist explains why the brain is a cheap prediction machine — and why forgetting is how memory works.
39:59ENFrom $6 million to $30 million ARR in three months: Garry Tan on YC’s AI boomModeration: Sarah Guo, Elad GilThe Y Combinator president tells Sarah Guo and Elad Gil why this batch looks like nothing he has seen in twenty years, and why a weak elephant is good news for startups.
59:47ENAaron Levie on AI Agents, SaaS Pricing and the Race Between Startups and IncumbentsGast: Aaron Levie · Moderation: Harry StebbingsThe Box CEO considers how AI might change business workflows, employment and software pricing, and why established companies and startups both have a chance.
39:00ENJPMorgan Has 150 Petabytes. GPT-4 Trained on Less Than One.Moderation: Sarah Guo, Elad GilScale AI founder Alexandr Wang tells No Priors why easy internet data is exhausted, why expert-plus-model teams still win, and why the path to AGI looks more like curing cancer than inventing a vaccine.
54:32ENNikesh Arora on Competition, Acquisitions and Leading Through ChangeGast: Nikesh Arora · Moderation: Harry StebbingsThe Palo Alto Networks CEO discusses product advantages, acquisition discipline, communication and the personal tradeoffs of leadership.
58:18ENJiaona Zhang on Product Scorecards, Strategy and Faster LearningGast: Jiaona Zhang · Moderation: Harry StebbingsLinktree’s product leader explains how KPI trees, weekly scorecards and collaborative rituals connect customer needs to business outcomes.
30:16ENSuno's CEO Thinks a Billion People Will Make Music, Not Just Stream ItModeration: Sarah Guo, Elad GilMikey Shulman tells No Priors why Suno skipped speech, charges from day one, and wants the line between listener and creator to disappear.
4:01:52ENPaul Rosolie: The Amazon Is a Machine of Death, and Every Heartbeat in It Is Worth SavingGast: Paul Rosolie · Moderation: Lex FridmanDeep in the Peruvian rainforest, the naturalist talks snakes, anacondas, uncontacted tribes, ayahuasca, and why he would rather protect this forest than look for aliens.
1:17:14ENDan Siroker on Repeat Founders, Fundraising and Building for Real ProblemsGast: Dan Siroker · Moderation: Harry StebbingsThe Optimizely and Limitless co-founder shares lessons on small teams, investor negotiations and product focus, and explains why founder motivation matters over the long term.
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