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3:43:01ENPut Hydrogen and CO2 in a Tube. Thermodynamics Wants Cells. Nothing Happens.Gast: Nick Lane · Moderation: Lex FridmanBiochemist Nick Lane talks Lex Fridman through hydrothermal vents, mitochondria, sex, consciousness, and why bacteria should be common while civilizations are not.
2:13:16ENEvery Atom in Your Body Was Forged in a Dead StarGast: Martin Rees · Moderation: Lex FridmanMartin Rees talks Lex Fridman through dark matter, alien life, one-way Mars trips, and why this century is the first in which one species holds the planet.
2:10:39ENDemis Hassabis: Solve Intelligence, Then Solve Everything ElseGast: Demis Hassabis · Moderation: Lex FridmanThe DeepMind CEO tells Lex Fridman why the Turing Test is the wrong exam, how AlphaFold rewrote biology, and why the quiet radio sky suggests we are probably alone.
2:55:05ENExtinction awareness is the human trait Mason wants to carry to the starsGast: Chris Mason · Moderation: Lex FridmanCornell geneticist Chris Mason on why seeing our own end creates a duty to engineer life for other worlds — and what a 500-year plan would actually require.
3:05:24ENTravis Oliphant wrote NumPy in an empty semester — and still wants open source to payGast: Travis Oliphant · Moderation: Lex FridmanThe creator of NumPy, SciPy, and Anaconda tells Lex Fridman how array thinking, a priced book, and the packaging wars shaped scientific Python.
3:02:43ENHumanity Cannot Survive on the Right Person Showing Up at the Right TimeGast: Max Tegmark · Moderation: Lex FridmanMIT physicist Max Tegmark tells Lex Fridman why AI should be as well understood as rockets, why 2020 was a warning on weapons and news, and why luck is a terrible long-term plan.
2:17:42ENThe building block of life is a bead on a string, not the whole proteinGast: Dmitry Korkin · Moderation: Lex FridmanDmitry Korkin tells Lex Fridman why protein domains, a triangular spike, and a conservative viral shell matter more than the AlphaFold headline, and why a Nobel laureate once answered a midnight forum post.
2:39:45ENThe obesity gene was never the obesity geneGast: Manolis Kellis · Moderation: Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
2:29:24ENWe Are the Descendants of the First Digital ComputerGast: Manolis Kellis · Moderation: Lex FridmanMIT computational biologist Manolis Kellis tells Lex Fridman why life is digital, why any two humans are 99.9 percent identical, and what evolutionary signatures reveal inside SARS-CoV-2.
1:02:14ENThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsGast: Robert Langer · Moderation: Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:12:03ENMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishGast: Daphne Koller · Moderation: Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
2:09:02ENA Hundred-Nanometer Machine That Is Not Quite AliveGast: Dmitry Korkin · Moderation: Lex FridmanDmitry Korkin walks through the structural genomics of SARS-CoV-2, from spike-ACE2 docking to drug-binding sites, vaccines, and cruise-ship simulations, recorded in the first spring of the pandemic.
39:33ENMars is not Plan B: Dava Newman on spacesuits, autonomy, and Spaceship EarthGast: Dava Newman · Moderation: Lex FridmanThe MIT Apollo professor and former NASA deputy administrator on Magellan’s crew, mechanical counterpressure, and why the next decade belongs to Earth.
1:17:29ENThe Algorithm Is Already Better. The Clinic Still Uses 1967.Gast: Regina Barzilay · Moderation: Lex FridmanMIT's Regina Barzilay on why deep learning already beats the breast-cancer 'density' score — and why data, liability, and incentives still will not move.
57:42ENA Brain Organoid Is Not a BrainGast: Paola Arlotta · Moderation: Lex FridmanHarvard developmental biologist Paola Arlotta on how the cerebral cortex is built, why timing and mechanical force are part of the code, and why a dish of stem cells is only a window onto that process.
1:45:49ENTrust at Scale: Elicit's Founders on Reasoning Languages, World Models and Automating the CompanyModeration: Nathan LabenzAndreas Stuhlmüller and Jungwon Byun explain how Elicit keeps frontier models checkable for high-stakes science, and where they think AI reasoning is heading.
56:20ENBiohub's Bet: Building Open AI World Models of Biology From Proteins Up to CellsModeration: Sarah Guo, Elad GilMark Zuckerberg, Priscilla Chan and Alex Rives explain why Biohub pairs a frontier AI lab with frontier wet-lab biology, and why it releases tools like ESMFold2 as open source.
1:03:59ENBuilding a World Model of Life: Biohub's Alex Rives on Why Better Measurement Must Come Before Virtual CellsModeration: Nathan LabenzBiohub's head of science explains why today's virtual cell models fall short, how a $1.8 billion data push aims to fix it, and what a five-year information-level model of the cell could unlock.
1:19:13ENAlien Intelligence, Radical Upside: Nathan Labenz on Why AI Is the Next Industrial RevolutionModeration: Nathan LabenzIn the second episode of The Cognitive Revolution, Nathan Labenz tells Erik Torenberg how he went from asteroid-watching AI skeptic to full-time AI scout, and lays out the upside and downside cases.
1:45:55ENFrom Static Structures to Moving Molecules: Where AI for Protein Design Stands After AlphaFold 3Moderation: Nathan LabenzComputational biochemist Amelie Schreiber walks Nathan Labenz through six months of progress in structure prediction, molecular dynamics, peptide and antibody models, and early agent-driven design workflows.
16:41ENAlphaFold 2 and the Protein-Folding Breakthrough: Why Lex Fridman Calls It a Landmark for AI and BiologyModeration: Lex FridmanA quick explainer on DeepMind's CASP14 result, how protein folding works, how AlphaFold 1 and 2 likely differ, and what the advance could unlock.









