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4:05:22ENIf We Cannot Say What Life Is, We Cannot Recognize AliensModeration: Lex FridmanAstrobiologist Sara Walker and chemist Lee Cronin argue that the hunt for alien life is really a hunt for a physics of memory, objects, and time.
1:12:09ENDoug Patti on State Machine Replication at Jane StreetYaron Minsky, Doug Patti · Jane StreetHow Concord and Aria use ordered logs and deterministic state machines to build recoverable trading services.
2:29:08ENStarvation Is a Weapon. Skye Fitzgerald Still Puts the Camera Down.Gast: Skye Fitzgerald · Moderation: Lex FridmanNearly 811 million people are hungry today, and 45 million stand at the edge of famine across 43 countries — while the food to feed them already exists.
3:25:22ENAndrew Huberman Lets No One Near Him for Two Hours Before a PodcastGast: Andrew Huberman · Moderation: Lex FridmanThe Stanford neuroscientist talks with Lex Fridman about building mental states, heat and cold, visual focus, and the four arrows of a relationship.
3:56:54ENWhen You Inflate Money at 7% and Call It 2%, You Are Bleeding the PatientGast: Michael Saylor · Moderation: Lex FridmanOn Lex Fridman's podcast, MicroStrategy CEO Michael Saylor argues that inflation is a vector, economics deserves a failing grade, and Bitcoin is the first ethical block of digital energy.
2:04:16ENPlease Don't Say That: Rick Rubin on Protecting the Room Where Art HappensGast: Rick Rubin · Moderation: Lex FridmanLex Fridman talks with the producer about listening blank, ruthless editing, Johnny Cash's "Hurt," and why a compliment can break a session.
3:21:29ENWhen something in the mind breaks, you see what it was forGast: Karl Deisseroth · Moderation: Lex FridmanStanford psychiatrist Karl Deisseroth talks with Lex Fridman about depression, schizophrenia, optogenetics, and why you can treat one symptom without a theory of everything.
2:48:27ENMost Rivals Loathe Each Other in PeaceGast: Chris Blattman · Moderation: Lex FridmanUniversity of Chicago economist Chris Blattman tells Lex Fridman why prolonged violence is rare, costly, and usually a bargaining failure — recorded in the fifth week of Russia's invasion of Ukraine.
3:47:25ENThe Original Internet Godfather Built Trust Among CybercriminalsGast: Brett Johnson · Moderation: Lex FridmanLex Fridman talks with Brett Johnson about ShadowCrew, social engineering, prison, and why most attacks still use holes everyone already knows about.
1:46:49ENAriel Ekblaw on Self-Assembling Habitats and Why the Real Space Cities Will FloatGast: Ariel Ekblaw · Moderation: Lex FridmanThe MIT Space Exploration Initiative director talks swarm tiles, lunar ants, and why Mars is a research station rather than a backup Earth.
41:17ENSid Sijbrandij on GitLab’s Remote Work, Feedback and BoardsGast: Sid Sijbrandij · Moderation: Harry StebbingsGitLab’s co-founder discusses the practices and trade-offs behind distributed work, leadership coaching and more useful board meetings.
2:10:56ENGod Cannot Be Expressed, Only AddressedGast: David Wolpe · Moderation: Lex FridmanRabbi David Wolpe talks with Lex Fridman about Judaism’s many pictures of God, friendship with atheists, and why a living tradition can argue with its own book.
4:05:51ENLife is the universe developing a memoryGast: Lee Cronin · Moderation: Lex FridmanChemist Lee Cronin tells Lex Fridman why life looks inevitable, how assembly theory could detect it on any world, and why silicon may never hold enough states for consciousness.
59:29ENHarley Finkelstein on Shopify, Leadership and Learning to Be Present at HomeGast: Harley Finkelstein · Moderation: Harry StebbingsThe Shopify president discusses communication, anxiety and the lessons he and his wife have learned about partnership and parenting.
2:49:41ENNazi Science Was Not Anti-Science. It Was Science with a Purity QuestGast: Robert Proctor · Moderation: Lex FridmanStanford historian Robert Proctor on how ideology, tobacco, and the taxonomic impulse turn scientists into widget-builders.
51:15ENAgility at Scale: Alignment, Autonomy and Two MindsetsDaniel Terhorst-North, Anna UrbaniakDaniel Terhorst-North and Anna Urbaniak discuss coordination and learning in large organizations.
45:59ENSahil Bloom on Building an Audience and Starting a Venture FundGast: Sahil Bloom · Moderation: Harry StebbingsThe writer and investor discusses consistent content, media-led investing, luck and a changing definition of hard work.
2:00:13ENHalf of America Dislikes Him. Zuckerberg Still Wants Presence, Not ScreensGast: Mark Zuckerberg · Moderation: Lex FridmanLex Fridman sits with Meta CEO Mark Zuckerberg on virtual presence, Instagram's teen research, free speech, and why every content decision costs the company half the country.
30:43ENJohn Doerr on Climate Investing, Google and a Plan for Net ZeroGast: John Doerr · Moderation: Harry StebbingsThe Kleiner Perkins investor discusses timing, portfolio risk and the measurable climate goals in Speed & Scale.
2:01:35ENA no-click iPhone exploit sold for $2.5 million. Silence was the only condition.Gast: Nicole Perlroth · Moderation: Lex FridmanNicole Perlroth tells Lex Fridman how zero-days, ransomware, and a privately owned power grid turned curiosity into everyday cyberwar.
2:10:29ENDevon Larratt’s Only Priority Is Winning. Everything Else Is a ToolGast: Devon Larratt · Moderation: Lex FridmanLex Fridman sits with one of the greatest arm wrestlers of all time to talk John Brzenk, Levan Saginashvili, Russian volume, a weaponized voice, and why everybody is beatable.
2:37:03ENNo One Knows How to Make a PencilGast: Tim Urban · Moderation: Lex FridmanWait But Why's Tim Urban spent five years on a book about why society is tearing itself apart, then sat down with Lex Fridman to talk aliens, Musk, Neuralink, and the war inside a procrastinator's head.
2:17:29ENThe knowledge doctors trust is built to sell drugsGast: John Abramson · Moderation: Lex FridmanHarvard physician John Abramson tells Lex Fridman how pharmaceutical companies captured medical knowledge, and why American healthcare spends more while delivering less.
30:53ENMark Cuban on Cost Plus Drugs, Hiring and Healthcare PricingGast: Mark Cuban · Moderation: Harry StebbingsIn a 2022 interview, Cuban describes the pharmacy’s early pricing model, his self-funded venture and his views on the US healthcare system.
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