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2:54:52ENThe Marvelous Proof Still Lives in the MarginModeration: Lex FridmanLuís and João Batalha, the brothers behind Fermat's Library, talk with Lex Fridman about hidden backstories, a publishing system that buys its own work twice, and how to sit with a paper until it finally clicks.
2:18:29ENYour Cortex Is 150,000 Brains Voting on a Coffee CupGast: Jeff Hawkins · Moderation: Lex FridmanJeff Hawkins tells Lex Fridman that intelligence is learning a model of the world, the neocortex is tens of thousands of independent maps that vote, and the fastest path to machine intelligence is reverse-engineering that sheet.
2:42:57ENThe Thousand-Pound Day Was Easy. The Years Before It Were Not.Gast: Chris Duffin · Moderation: Lex FridmanLex Fridman talks with strength athlete and engineer Chris Duffin about squatting and deadlifting 1,000 pounds for reps, stacking the torso like a pressure vessel, and a childhood spent handling live rattlesnakes.
2:30:30ENThe Fallacy of the Successful First StepGast: Ishan Misra · Moderation: Lex FridmanBerkeley's Jitendra Malik explains why computer vision still looks easy, why fully autonomous driving is not near, and what children know that today's networks do not.
3:01:47ENA hundred miles is a lifetime compressed into one dayGast: Zach Bitter · Moderation: Lex FridmanZach Bitter talks with Lex Fridman about the 100-mile mind, quitting, aerobic training, fat-adapted fueling, and a run across America.
2:13:21ENThe Fourth Deduction Often Turns Out to Be the First PrincipleGast: Cumrun Vafa · Moderation: Lex FridmanHarvard string theorist Cumrun Vafa on why physicists distrust deduction, how a graviton fell out of a formula nobody wrote for gravity, and what extra dimensions are actually for.
1:44:54ENIf the meat needs a sauce, start over with the animalGast: Anya Fernald · Moderation: Lex FridmanBelcampo co-founder Anya Fernald tells Lex Fridman why cooking is service, why "grass-fed" is an unregulated word, and why regenerative grazing cannot scale without human attention.
2:36:06ENThe Experience Is Not in the Pill. Rick Doblin Spent Decades Proving the Context Is.Gast: Rick Doblin · Moderation: Lex FridmanThe MAPS founder walks Lex Fridman from Huxley's reducing valve to a Phase 3 MDMA trial for PTSD, arguing that legality, safety, and culture matter more than new molecules.
2:39:53ENThere's Something at the Edge of the Solar SystemGast: Konstantin Batygin · Moderation: Lex FridmanCaltech planetary astrophysicist Konstantin Batygin tells Lex Fridman how a hypothesized five-Earth-mass world shepherds the distant Kuiper Belt — and why a photograph would end the argument.
2:37:21ENEmma Goldman Told Lenin the Revolution Was Already WrongGast: Michael Malice · Moderation: Lex FridmanMichael Malice talks with Lex Fridman about totalitarianism, quiet heroism, and why anarchism is a relationship rather than a place.
2:09:48ENRoger Reaves Flew Cocaine for Escobar. He Says the Money Was Never Worth ItGast: Roger Reaves · Moderation: Lex FridmanLex Fridman talks with one of history's most prolific drug smugglers about the Medellín Cartel, Barry Seal, two shoot-downs, and 33 years in prison.
1:59:28ENSara Walker says “what is life?” is the wrong questionGast: Sara Walker · Moderation: Lex FridmanThe astrobiologist and theoretical physicist tells Lex Fridman that origin-of-life science is stuck on molecules, and that causation, assembly, and planetary-scale information are closer to the real problem.
1:57:38ENThe Best Leadership Uses the Least ForceGast: Jocko Willink · Moderation: Lex FridmanRetired Navy SEAL Jocko Willink talks with Lex Fridman about just war, ego, Musk and Jobs, 4 a.m. discipline, and what jiu jitsu taught him about command.
2:00:48ENNorth Korea Banned the Word for Famine. Yeonmi Park Still Says It.Gast: Yeonmi Park · Moderation: Lex FridmanA North Korean defector tells Lex Fridman how a regime hides hunger, how Animal Farm explained her country, and why she hears echoes of that silence in American life.
1:58:12ENThe Universe Doesn't Sacrifice. That's Why Phosphine Might Mean Life.Gast: Clara Sousa-Silva · Moderation: Lex FridmanQuantum astrochemist Clara Sousa-Silva on the contested Venus detection, a molecule nobody could spell, and why she treats cosmic meaninglessness as a relief.
3:17:09ENWhat Science Is Left When Institutions Decide What Cannot Be SaidGast: Bret Weinstein · Moderation: Lex FridmanEvolutionary biologist Bret Weinstein talks with Lex Fridman about lab-leak evidence, ivermectin, captured public-health agencies, and why the 1% at the fringe is the key to progress.
1:19:49ENAll-In E37: New York’s Primary, Pandemic Origins and App Store PowerModeration: Jason Calacanis, Chamath Palihapitiya, David Sacks, David FriedbergA 2021 discussion of election messaging, uncertain pandemic evidence and competing views on antitrust.
2:59:12ENNature Never Dealt This CardGast: Rob Reid · Moderation: Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
4:57:51ENCharles Hoskinson Entered Crypto Expecting PrisonGast: Charles Hoskinson · Moderation: Lex FridmanThe Cardano founder talks with Lex Fridman about proof of stake, formal methods, and why a blockchain should behave like a law of physics.
4:15:19ENExponential tools, Stone Age game theoryGast: Daniel Schmachtenberger · Moderation: Lex FridmanDaniel Schmachtenberger tells Lex Fridman why every leap in physical technology breaks the last social operating system — and why Bretton Woods cannot bind what comes next.
2:41:47ENGeometry Is the Cilantro of MathGast: Jordan Ellenberg · Moderation: Lex FridmanJordan Ellenberg tells Lex Fridman that the last 150 years of mathematics have been about one question: when two things count as the same.
1:41:34ENAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGast: David Sinclair · Moderation: Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
3:02:00ENVitalik Buterin Walked Away From Billions of Dog Coins — Then Mapped Ethereum's Next DecadeGast: Vitalik Buterin · Moderation: Lex FridmanIn a three-hour conversation with Lex Fridman, the Ethereum co-founder explains the Shiba Inu dump, proof of stake, rollups, and why he thinks most evil comes from fear.
2:22:20ENThe closer quarks get, the weaker they pullGast: Frank Wilczek · Moderation: Lex FridmanNobel physicist Frank Wilczek talks with Lex Fridman about asymptotic freedom, beauty, dark matter, consciousness, and whether a theory of everything would even help.
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