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1:12:36ENKate Darling on Why We Name the Roomba and Mourn the Bomb RobotGast: Kate Darling · Moderation: Lex FridmanAn MIT Media Lab researcher argues that our feelings about machines track the history of animal domestication — and that design can steer that instinct for better or worse.
1:38:33ENMaybe people are rational under different assumptionsGast: Anca Dragan · Moderation: Lex FridmanAnca Dragan talks with Lex Fridman about inverse reinforcement learning, autonomous driving, and why a written reward is evidence rather than law.
1:39:56ENWhy Marcus Hutter Treats Compression as Intelligence ItselfGast: Marcus Hutter · Moderation: Lex FridmanThe DeepMind researcher behind AIXI tells Lex Fridman why a Wikipedia compression contest, Solomonoff induction, and an incomputable formula belong in the same conversation.
1:45:58ENNine of ten colleagues said far-field speech was impossibleGast: Rohit Prasad · Moderation: Lex FridmanRohit Prasad, Amazon’s vice president and head scientist for Alexa, talks with Lex Fridman about conversational AI, the Alexa Prize, trust, and why a 20-minute chat is still years away.
1:23:01ENYou Cannot Ask a Question You Have No Words ForGast: Judea Pearl · Moderation: Lex FridmanA teenager spent three days in bed with a fever after learning that geometry could be done in algebra — then spent a career giving cause and effect a mathematics.
44:48ENChris Urmson: The Path to Driverless Cars Splits Away From the One That Lets You NapGast: Chris Urmson · Moderation: Lex FridmanLex Fridman talks with Aurora CEO Chris Urmson about the DARPA races, why lidar is a tool rather than a crutch, and why Level 2 economics will not grow into true autonomy.
1:46:01ENThe Night AlphaStar Beat TLO, the Team Went to a BarGast: Oriol Vinyals · Moderation: Lex FridmanOriol Vinyals on how DeepMind turned StarCraft II into a sequence problem, built a league of agents, and still refuses to call the game solved.
1:01:24ENLeslie Kaelbling: You Buy the Ticket Before You Can Plan the AirportGast: Leslie Kaelbling · Moderation: Lex FridmanThe MIT roboticist tells Lex Fridman why abstractions, belief-space control, and built-in bias matter more than picking a tribe of symbols or neural nets.
1:06:17ENLibratus Beat the World's Best Poker Players Without a Neural NetworkGast: Tuomas Sandholm · Moderation: Lex FridmanTuomas Sandholm tells Lex Fridman how game theory, abstraction, and search — not deep learning — took heads-up no-limit Texas Hold'em, and why the harder work is deploying that toolkit outside the casino.
1:45:49ENTrust at Scale: Elicit's Founders on Reasoning Languages, World Models and Automating the CompanyModeration: Nathan LabenzAndreas Stuhlmüller and Jungwon Byun explain how Elicit keeps frontier models checkable for high-stakes science, and where they think AI reasoning is heading.
1:21:44ENFrom Rowing to Steering: Inside OpenAI's Push Toward Persistent AI CoworkersModeration: Lenny RachitskyTara Seshan, who leads product for Codex and ChatGPT Work at OpenAI, explains how PM work changes when agents do the rowing and people do the steering.
1:22:43ENA Colleague With Its Own Computer: How a Small Team Built Grok Bot in a MonthModeration: Lenny RachitskyRoman Ugarte of SpaceXAI explains the decisions, hand-held onboarding and product philosophy behind Grok Bot, and what Cursor's culture taught him about staying ahead.
1:30:52ENBuilding Minds from Unified Theories: Nate Derbinsky on Cognitive Architectures, Soar, and the Case for ForgettingGast: MIT AGI · Moderation: Lex FridmanA guest lecture in MIT's AGI course on how cognitive architectures try to assemble human-level intelligence, and how studying human memory made the Soar architecture faster and better.
1:50:25ENFrom Email Client to AI Agent: How Shortwave Rebuilt Itself for the Tidal WaveModeration: Nathan LabenzShortwave CEO Andrew Lee explains the agent architecture, caching economics and tiny-team culture behind the company's hockey-stick growth.
37:23ENFrom Chat to Always-On Agents: OpenAI's Tibo Sottiaux on Dots, Open Ecosystems and What Comes NextModeration: Lenny RachitskyThe head of ChatGPT and Codex, speaking hours after a DevDay launch of more than 20 products, explains the vision for a personal agent that works around the clock.
57:11ENFrom Artifact to Organism: Microsoft's Asha Sharma on Products That Learn and an Agentic SocietyGast: Asha Sharma · Moderation: Lenny RachitskyMicrosoft's AI platform product chief explains why products are becoming living systems tuned by post-training, why interfaces are shifting toward code and composability, and how agents may reshape the org chart.
1:42:11ENTwenty Agents, 1.2 Humans: Inside SaaStr's AI-Run Sales TeamModeration: Lenny RachitskyJason Lemkin explains how SaaStr replaced a ten-person go-to-market team with AI agents, what it took to train them, and who survives the shift.
1:46:35ENHire Your Agents Like Employees: Claire Vo's Field Guide to Running Nine OpenClawsModeration: Lenny RachitskyClaire Vo explains how she went from losing her family calendar to OpenClaw to running a team of specialized agents across her business, podcast, course and household.
45:00ENAgents Everywhere: OpenAI's Blueprint for Tool Use, Evals, and Computer-Use InfrastructureModeration: Jacob EffronOpenAI's API platform team explains how agents are moving from deterministic workflows to reasoning-driven tool use, and what developers still lack.
1:34:06ENRide the Models: Dan Shipper's Bets on Super-Agents, Codex, SaaS and the Human Jobs AI CreatesModeration: Lenny RachitskyEvery CEO Dan Shipper makes a dozen predictions for how work will look in a year, from company-wide Slack agents to why the AI job apocalypse isn't coming.
29:03ENNotion's Simon Last on Rewriting the AI Harness Every Six Months and Managing a Swarm of AgentsModeration: Sarah Guo, Elad GilThe Notion co-founder traces the product's path from a writing assistant to custom background agents, and describes how coding agents changed the way he builds.









