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3:36:56ENPsychiatry Has Never Found Its PenicillinModeration: Lex FridmanHistorian Andrew Scull tells Lex Fridman why the field can ease symptoms, has never cured a major mental illness, and keeps paying for overconfidence with patients' lives.
1:02:32ENThe More Important the Issue, the Less Anyone Discusses ItModeration: Lex FridmanBernie Sanders tells Lex Fridman why drug lobbyists, campaign cash, and a healthcare system built for profit keep the biggest American problems off the table.
1:47:18ENA Cannabis Clip Sat Quiet for a Year. Then It Hit X.Gast: Andrew Huberman · Moderation: Lex FridmanAndrew Huberman talks with Lex Fridman about online pile-ons, still minds, sharks, ayahuasca, and the slow work of picking who you eat with.
2:28:37ENThe Marshals Came for an Underground City. RFK Jr. Still Wants a President Who Can Say NoGast: Robert F. Kennedy Jr · Moderation: Lex FridmanOn Independence Day 2023, Lex Fridman sat with Robert F. Kennedy Jr. for two and a half hours on Cuba, Ukraine, the CIA, pharma, and why the shopping cart still has to go back.
3:15:07ENWikipedia Worked Once Writing Stopped Feeling Like Grad SchoolGast: Jimmy Wales · Moderation: Lex FridmanJimmy Wales tells Lex Fridman how Nupedia's seven-stage review died, why Wikipedia still refuses ads and governments, and what large language models should actually do with an encyclopedia.
4:27:46ENHalf a Million Girls in Wells, and We Still Change the ChannelGast: Sam Harris · Moderation: Lex FridmanSam Harris tells Lex Fridman why emotional contagion is a bad moral compass, why Trump broke norms more than laws, and why Twitter, COVID, and AGI all look like failures of seriousness.
4:11:06ENThe climate problem is real. The 12-year asteroid story is not.Moderation: Lex FridmanBjørn Lomborg and Andrew Revkin tell Lex Fridman why vulnerability, cheaper tons of carbon, and energy innovation matter more than apocalyptic deadlines.
2:43:51ENTwo Tubes, Millimeters Apart: Jonathan Reisman on the Honest Design of the Human BodyGast: Jonathan Reisman · Moderation: Lex FridmanThe emergency physician and author of The Unseen Body walks Lex Fridman from the throat to the Arctic, arguing that anatomy is mostly brilliant, sometimes a near-miss, and always a story written in scars.
1:42:06ENJonathan Haidt: Instagram Is Not 'Generally Positive' for Teen MindsGast: Jonathan Haidt · Moderation: Lex FridmanThe NYU social psychologist answers Mark Zuckerberg on adolescent mental health and argues that one business model rewired childhood and then the public square.
2:55:05ENExtinction awareness is the human trait Mason wants to carry to the starsGast: Chris Mason · Moderation: Lex FridmanCornell geneticist Chris Mason on why seeing our own end creates a duty to engineer life for other worlds — and what a 500-year plan would actually require.
2:29:08ENStarvation Is a Weapon. Skye Fitzgerald Still Puts the Camera Down.Gast: Skye Fitzgerald · Moderation: Lex FridmanNearly 811 million people are hungry today, and 45 million stand at the edge of famine across 43 countries — while the food to feed them already exists.
2:49:41ENNazi Science Was Not Anti-Science. It Was Science with a Purity QuestGast: Robert Proctor · Moderation: Lex FridmanStanford historian Robert Proctor on how ideology, tobacco, and the taxonomic impulse turn scientists into widget-builders.
2:17:29ENThe knowledge doctors trust is built to sell drugsGast: John Abramson · Moderation: Lex FridmanHarvard physician John Abramson tells Lex Fridman how pharmaceutical companies captured medical knowledge, and why American healthcare spends more while delivering less.
2:21:49ENFocused Protection, Not Lockdowns: Jay Bhattacharya on What Public Health Got WrongGast: Jay Bhattacharya · Moderation: Lex FridmanThe Stanford physician and co-author of the Great Barrington Declaration tells Lex Fridman why age-stratified risk, seroprevalence data, and the ignored costs of isolation pointed to a different COVID strategy.
1:08:04ENBreakthroughs Run on Speed. Trust Runs on Patience.Gast: Albert Bourla · Moderation: Lex FridmanPfizer CEO Albert Bourla talks with Lex Fridman about the November 2020 unblinding, a $2.3 billion all-in bet, and why a historic vaccine still divided the public.
4:55:09ENJamie Metzl Puts the Lab-Leak Odds at 85 PercentGast: Jamie Metzl · Moderation: Lex FridmanThe genetic-engineering author walks Lex Fridman through the circumstantial case for a Wuhan accident, the cover-up he says is no longer debatable, and why the next pandemic will be decided by transparency, not blame.
1:26:53ENFrancis Collins Cannot Exclude a Lab LeakGast: Francis Collins · Moderation: Lex FridmanThe outgoing NIH director talks with Lex Fridman about COVID origins, gain-of-function research, Anthony Fauci, vaccines, and why scientific certainty is the wrong pose.
1:46:47ENA Perfect Rapid Test Would Fail the FDA. Michael Mina Explains Why That Is the PointGast: Michael Mina · Moderation: Lex FridmanThe Harvard immunologist tells Lex Fridman that paper-strip antigen tests answer the only public-health question that matters—are you infectious right now—and that one presidential sentence could unlock them.
1:11:03ENCarl Hart’s case that addiction lives outside the moleculeGast: Carl Hart · Moderation: Lex FridmanThe Columbia psychologist tells Lex Fridman that most drug effects are positive, that alcohol withdrawal is deadlier than heroin’s, and that the war on drugs pays a long list of people to keep a scapegoat in place.
4:06:06ENShe Picked Up a Perfectly Laced Boot and Said They Could Reuse ItGast: Kelsi Sheren · Moderation: Lex FridmanKelsi Sheren was a 19-year-old, 103-pound Canadian artillery gunner on an M777 howitzer in Afghanistan; she came home with the light switch off and spent a decade finding a way back.
2:44:08ENForty Feet Behind: A New York Firefighter's 9/11Gast: Niels Jorgensen · Moderation: Lex FridmanNiels Jorgensen, an FDNY veteran at Ground Zero on September 11, 2001, tells Lex Fridman who did not come home, what the dust did to the living, and why September 12 still matters.
3:28:40ENThere Are More Viruses in a Liter of Seawater Than People on EarthGast: Vincent Racaniello · Moderation: Lex FridmanColumbia virologist Vincent Racaniello talks Lex Fridman through ocean-scale particle counts, mRNA vaccines, and why speaking with false certainty does more damage than a virus.
2:48:18ENHumans are the only species that skip sleep on purposeGast: Matt Walker · Moderation: Lex FridmanBerkeley sleep scientist Matt Walker talks with Lex Fridman about why we sleep, what caffeine and dreams actually do, and whether passion can justify the health cost of staying up.
1:44:54ENIf the meat needs a sauce, start over with the animalGast: Anya Fernald · Moderation: Lex FridmanBelcampo co-founder Anya Fernald tells Lex Fridman why cooking is service, why "grass-fed" is an unregulated word, and why regenerative grazing cannot scale without human attention.
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