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23:05ZH → EnglishRyo Lu: When We Can Make Anything, Do We Know What We Want?Ryo LuFrom an AI-generated journal to a jazz ensemble, Ryo Lu explores judgment, life and collaboration alongside powerful tools.
48:39ENJohn Somorjai on Salesforce’s Acquisition Strategy in the AI EraAlex Immerman, John Somorjai · a16zSalesforce’s acquisition leader explains build-versus-buy decisions, AI pricing, Slack and the diligence issues that can stop a deal.
49:37ENRamtin Naimi on AI Venture Capital’s Growing Funding CrunchGuest Ramtin Naimi · Host Patrick O'ShaughnessyThe Abstract Ventures founder explains faster financing rounds, capital-hungry AI labs and his search for overlooked founders.
1:07:12ENHard Fork on the Midterms, AI Backlash and Tech Political SpendingGuest Erin Griffith, Ezra Klein, Theodore Schleifer · Host Max ReadMax Read, Ezra Klein, Erin Griffith and Theodore Schleifer discuss data-center opposition and the limits of billionaire campaign spending.
11:04ENChris Williamson Discusses the Political Divide Between Young Men and WomenHost Chris WilliamsonWilliamson and an unnamed guest discuss survey patterns, party representation and working-class concerns.
29:42ENArtie Shevchenko and Titus Winters on Code Health in the AI EraTitus Winters, Artie Shevchenko · AdobeThe authors discuss complexity, human review, testing and why interfaces and state deserve attention in AI-assisted development.
14:58ENSparsh Jain on Building Experiential Memory for AI AgentsSparsh Jain · CentralAgent AIAn agent-memory lifecycle forms, updates and retrieves lessons while evaluation loops manage changing context.
1:46:03ENCaleb Followill on Family, Fame and Finding His Way Back to MusicGuest Caleb Followill · Host Theo VonThe Kings of Leon frontman talks with Theo Von about a traveling childhood, the band’s rise and learning to enjoy performing again.
17:27ENPhilipp Schmid: Seven Things an AI Coworker NeedsPhilipp Schmid · Google DeepMindA walkthrough of managed agents, skills, credentials and controls, culminating in a scheduled portfolio-audit demo.
18:13ENSid Pednekar: Judgment Is the Scarce Resource in AI AdoptionSid PednekarA framework for choosing valuable problems, building shared capabilities and turning experience into organizational learning.
14:04ENFrank Long on Building AI Investment Workflows Around QualityFrank Long · CoatueCoatue’s Frank Long breaks investing into information, analysis and decision steps, and argues for choosing the right combination of code, models and people.
50:50ENFabian Theis on Virtual Cells, Organoids and Closing the Lab LoopGuest Fabian Theis · Host RJ Honicky, Brandon AndersonThe Helmholtz Munich researcher explains perturbation models, biological benchmarks and the work required to connect prediction with experiments.
17:52ENCameron Wolfe on Evaluating AI When Answers Are SubjectiveCameron Wolfe · NetflixNetflix’s Cameron Wolfe outlines human review, calibrated model judges and production monitoring as a repeatable evaluation loop.
54:08ENVlad Tenev on Ownership, Tokenization and AI TradingGuest Vlad Tenev · Host Sarah GuoRobinhood’s CEO discusses his vision for wider asset ownership, mathematical AI and agentic finance with Sarah Guo.
42:06ENData-Center Power, Financing and Compute: A Panel with Yixing Xu, Alex Yeh and Bruce LiuGuest Yixing Xu, Alex Yeh, Bruce Liu · Host Christina XuBuilders and an investor discuss transmission constraints, delivery delays, lease mismatches and the economics of selling compute.
1:19:29ENScaling Slack and GitHub: Maude Lemaire on Load, Shards and Reliable PlatformsGuest Maude Lemaire · Host Gergely OroszThe principal engineer explains a Slack data migration, realistic load testing, GitHub’s shard constraints and her approach to AI-assisted performance work.
41:02ENTheo on PewDiePie’s Local AI Project, Training Data and Model SafetyTheo, PewDiePieA reaction to the Ajax and Odysius project becomes a discussion of opt-in data, agent traces, fine-tuning and local model tradeoffs.
20:45ENJohn Stecher and Scott Worland on Building AI Systems That Can ChangeScott Worland, John Stecher · Norm AIThe Blackstone and Norm AI CTOs discuss data strategy, evaluations, production controls and when to wait for a better model.
23:55ENSusan Wojcicki’s Family on Her Life and Lung-Cancer ResearchGuest Dennis Troper, Esther Wojcicki, Anne Wojcicki, Janet Wojcicki · Host Marina MogilkoHer family remembers her priorities as a mother and leader and discusses the foundation’s goals for research and earlier detection.
1:01:05ENDiogo Almeida on Decision Models, Benchmark Fatigue and Agent ReliabilityGuest Diogo Almeida · Host Jacob EffronThe creator of Jev discusses structured decisions, model evaluation and the practical problems of building with AI agents.
2:16:39ENGregory Forth on Flores Fossils and Reports of Humanlike BeingsGuest Gregory Forth · Host Joe RoganThe anthropologist discusses fieldwork, local traditions and a disputed hypothesis about a surviving hominin.
52:36ENKim Maida and Mason Egger: Secure Agent Access and Durable ExecutionKim Maida, Mason Egger · KeycardAn expense-approval workshop combines per-call OAuth token exchange with Temporal workflows that recover after a worker fails.
42:40ENDaniel Terhorst-North: Use Generative AI to Go Broader, Not Just FasterDaniel Terhorst-North · Dan North & AssociatesA software practitioner shares how an AI-assisted teaching toolkit led him to “adjacent engineering,” larger test-first steps and external guardrails.
1:43:54ENJoshua Monrad on AI, Biosecurity and Building Layers of DefenseGuest Joshua Monrad · Host Nathan LabenzSentinel Bio’s co-founder discusses uncertain AI-related biological risks, practical safeguards and the long work of global resilience.
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